1.
J Pharm Biomed Anal
; 15(11): 1781-7, 1997 Jul.
Article
in English
| MEDLINE
| ID: mdl-9260676
ABSTRACT
The optimisation of the separation of the antimalarial drugs, proguanil and atovaquone and six related compounds was obtained by two independent optimisation steps; the optimisation of the mobile phase composition and the optimisation of the pH. This was done using window selection diagrams (WSD) and a mixture design. The optimal conditions allow the identification of the six related compounds down to 0.1%.