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1.
Article in English | MEDLINE | ID: mdl-32198229

ABSTRACT

OBJECTIVE: To investigate the possible human leukocyte antigen (HLA) association of both myelin oligodendrocyte glycoprotein (MOG-IgG)-associated diseases (MOGAD) and aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSDs) in the Dutch population with European ancestry to clarify similarities or differences in the immunogenetic background of both diseases. METHODS: Blood samples from patients in the Dutch national MS/NMOSD expert clinic were tested for MOG-IgG and AQP4-IgG using a cell-based assay. HLA Class I and II genotyping was performed in 43 MOG-IgG-seropositive and 42 AQP4-IgG-seropositive Dutch patients with European ancestry and compared with those of 5,604 Dutch healthy blood donors. RESULTS: No significant HLA association was found in MOG-IgG-seropositive patients. The AQP4-IgG-seropositive patients had a significant higher frequency of HLA-A*01 (61.9% vs 33.7%, OR 3.16, 95% CI, 1.707-5.863, p after correction [pc] = 0.0045), HLA-B*08 (61.9% vs 25.6%, OR 4.66, 95% CI, 2.513-8.643, pc < 0.0001), and HLA-DRB1*03 (51.2% vs 27.6%, OR 2.75, 95% CI, 1.495-5.042, pc = 0.0199) compared with controls. CONCLUSIONS: The present study demonstrates differences in the immunogenetic background of MOGAD and AQP4-IgG-positive NMOSD. The strong positive association with HLA-A*01, -B*08, and -DRB1*03 is suggestive of a role of this haplotype in the etiology of AQP4-IgG-positive NMOSD in patients with European ancestry, whereas in MOGAD no evidence was found for any HLA association in these disorders.


Subject(s)
Aquaporin 4/immunology , Demyelinating Autoimmune Diseases, CNS/genetics , Demyelinating Autoimmune Diseases, CNS/immunology , HLA Antigens/genetics , Myelin-Oligodendrocyte Glycoprotein/immunology , Adolescent , Adult , Child , Child, Preschool , Demyelinating Autoimmune Diseases, CNS/blood , Female , Humans , Male , Middle Aged , Netherlands , Neuromyelitis Optica/blood , Neuromyelitis Optica/genetics , Neuromyelitis Optica/immunology , White People , Young Adult
2.
Mult Scler ; 21(12): 1513-20, 2015 Oct.
Article in English | MEDLINE | ID: mdl-25662345

ABSTRACT

BACKGROUND: Acquired demyelinating syndromes (ADS) in children are a group of distinct first immune-mediated demyelinating events of the central nervous system (CNS). Predictive biomarkers for future diagnosis are lacking. A putative target antigen is myelin oligodendrocyte glycoprotein (MOG). We analyzed the presence of MOG antibodies in a cohort of ADS patients in The Netherlands. METHODS: Using a cell-based assay, we analyzed 117 children with ADS from a nationwide cohort, whom were divided into five groups: optic neuritis (ON; n = 20), transverse myelitis (TM; n = 7), other monofocal ADS (n = 22), polyfocal ADS without encephalopathy (n = 44) and polyfocal ADS with encephalopathy (n = 24). Additionally, we tested children with other neurological diseases (OND; n = 13), healthy children (n = 31) and adult polyfocal ADS plus encephalopathy (ADEM) patients (n = 29). RESULTS: We found that 21 of the 117 children with ADS tested anti-MOG seropositive (18%). The group of patients with ADEM had the highest prevalence of anti-MOG seropositivity (42% versus 18% in the non-encephalopathic polyfocal ADS patients). Although 47 ADS children had a final diagnosis of multiple sclerosis (MS), in only one of them were MOG antibodies detected (2%), with only borderline positivity. Only 1 out of the 29 adult ADEM patients tested anti-MOG seropositive. CONCLUSIONS: MOG antibodies are strongly skewed towards ADS children that present with an ADEM-like disease onset. The presence of such antibodies pleads against a future diagnosis of MS.


Subject(s)
Autoantibodies/blood , Brain Diseases/blood , Demyelinating Autoimmune Diseases, CNS/blood , Myelin-Oligodendrocyte Glycoprotein/immunology , Optic Neuritis/blood , Adolescent , Adult , Biomarkers/blood , Brain Diseases/epidemiology , Child , Child, Preschool , Demyelinating Autoimmune Diseases, CNS/epidemiology , Encephalomyelitis, Acute Disseminated/blood , Encephalomyelitis, Acute Disseminated/epidemiology , Female , Humans , Infant , Male , Myelitis, Transverse/blood , Myelitis, Transverse/epidemiology , Netherlands/epidemiology , Optic Neuritis/epidemiology , Syndrome
3.
Mult Scler ; 19(10): 1257-8, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23996597
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