ABSTRACT
A 99mTc-DTPA radiorenographic study, supported by excretory urography, blood chemistry and eventually histology was performed on 8 chacma baboons (Papio ursinus) after surgical induction of unilateral renal vein hypertension. Frequent sequential repeat renograms during 6 post-operative months detected fluctuating renal behaviour but did not reveal typical course of the disease. Neither did any one of the radiorenographic parameters (TP, T1/2, FF, relative clearances and perfusion) prove to be more sensitive than the others in detecting abnormalities. Initial microscopic or macroscopic haematuria and proteinuria in general eventually cleared up. Light microscopy demonstrated only mild abnormalities. The effects of venous occlusion of the kidney and the prognosis seemed to be variable as was reflected by radiorenography.
Subject(s)
Hypertension, Renovascular/diagnostic imaging , Organometallic Compounds , Pentetic Acid , Radioisotope Renography , Renal Veins , Technetium , Animals , Hypertension, Renovascular/etiology , Male , Papio , Technetium Tc 99m Pentetate , Time FactorsABSTRACT
Thermodilution cardiac output determinations and multigated equilibrium blood-pool scintigraphy were performed in ten healthy chacma baboons (Papio ursinus). The correlation was moderately good between both the radionuclide and thermodilution stroke volume (r = 0.58, SEE = 3 ml; SVth = 0.78SVr + 15.6 ml) as well as the cardiac output (r = 0.72, SEE = 0.2 liter/min; COth = 0.56 Cor + 2.1 liter/min). The attenuation depth dr as determined by radionuclide techniques was found to correlate well with the radiologically determined values dx (r = 0.8, SEE = 0.4 cm; dx = 0.87dr + 0.72 cm) which validated the depth values used in the calculations.
