1.
Bioorg Med Chem Lett
; 10(1): 71-4, 2000 Jan 03.
Article
in English
| MEDLINE
| ID: mdl-10636247
ABSTRACT
The synthesis and biological activity of a series of benzofuro[3,2-c]pyridines and a benzothieno[3,2-c]pyridine are described. These compounds exhibit high affinity for the alpha 2-adrenoceptor, with high selectivity versus the alpha 1-receptor. Compound 1 also shows potent in vivo central activity and has been selected for further biological and clinical evaluation.