ABSTRACT
Propofol (25 patients) or midazolam (25 patients) was used to provide sedation in patients who underwent abdominal or orthopaedic surgery under epidural anaesthesia after intravenous premedication with droperidol 1 mg and fentanyl 20 micrograms. The quality of sedation whilst the block was performed, was assessed as good in 19 patients after propofol 1.49 mg/kg but six patients exhibited uncontrolled movement. Good sedation was provided in 22 patients after midazolam 3 mg. A mean infusion rate of propofol of 1.74 mg/kg/hour resulted in easily controllable sedation during the procedure. Eleven patients given midazolam required no further sedation but a mean of 5.79 mg was needed in the remaining 14 patients; the dose was unpredictable in individual patients. Recovery was significantly more rapid in the propofol group.
Subject(s)
Anesthesia, Epidural , Hypnotics and Sedatives , Midazolam , Phenols , Adolescent , Adult , Droperidol , Female , Fentanyl , Humans , Hypnotics and Sedatives/administration & dosage , Male , Midazolam/administration & dosage , Middle Aged , Phenols/administration & dosage , Preanesthetic Medication , Propofol , Surgical Procedures, OperativeABSTRACT
In regional anesthesia our experience shows that the association of small dose of fentanyl (20 mcg i.v.) and droperidol (1 mg i.v.) with a small dose of benzodiazepine i.v. injected 5' after provides a good sedation during surgery. The choice of the benzodiazepine is based on the duration of anesthesia: midazolam (1.5 or 3 mg i.v.) in anesthesia with a duration less or equal to 1 h 30'; flunitrazepam (0.2 mg or 0.4 mg i.v.) in anesthesia with a duration longer than 1 h 30'.
