1.
Methods Find Exp Clin Pharmacol
; 10(6): 381-5, 1988 Jun.
Article
in English
| MEDLINE
| ID: mdl-3412048
ABSTRACT
The authors describe a new method to screen antiarrhythmics drugs by continuous infusion of calcium chloride in albino rat. Results are compared with those of a single injection method. Three reference compounds were tested: verapamil, nifedipine and trimetazidine. Verapamil and trimetazidine were shown to be equally active by the two methods. A fourth compound, synthetized in the laboratory, was active in the various arrhythmia models and, in particular, in the novel model described.