1.
Horm Res
; 10(6): 303-9, 1979.
Article
in English
| MEDLINE
| ID: mdl-157317
ABSTRACT
The case of a true hermaphrodite, with a normal ovary and an ovotestis is presented. The ovotestis was removed and incubated in vitro with tritiated steroids (testosterone, dehydroepiandrosterone, pregnenolone and 17 alpha-hydroxyprogesterone). Labeled metabolites were isolated and identified. Based upon these findings, a pathway of steroid biogenesis in this abnormal gonadal tissue is suggested. The ovotestis studied did not contain all the enzymes involved in ovarian steroidogenesis: 3 beta-hydroxysteroid dehydrogenase, isomerase, 17--20 desmolase and 17 beta-hydroxysteroid dehydrogenase were present, but other important enzymes, such as 16 and 17-hydroxylases, and aromatizing enzyme systems, were deficient or absent.
Subject(s)
Dehydroepiandrosterone/metabolism , Disorders of Sex Development/metabolism , Gonads/metabolism , Hydroxyprogesterones/metabolism , Pregnenolone/metabolism , Testosterone/metabolism , Disorders of Sex Development/pathology , Disorders of Sex Development/surgery , Disorders of Sex Development/therapy , Female , Humans , In Vitro Techniques
2.
Acta Endocrinol (Copenh)
; 66(4): 637-47, 1971 Apr.
Article
in English
| MEDLINE
| ID: mdl-4251844