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Eur J Clin Nutr ; 54(11): 840-3, 2000 Nov.
Article in English | MEDLINE | ID: mdl-11114678

ABSTRACT

OBJECTIVE: To evaluate alpha-linolenic acid (ALA) (18∶3 n-3) and linolenic acid (LA) (18∶2 n-6) in cholesterol esters (CE) as markers of ALA and LA dietary intakes in preterm infants. SUBJECTS: Forty-five preterm infants: two groups fed different formulas, the third fed human milk. DESIGN: ALA and LA dietary intakes were precisely recorded in each infant to accurately determine the cumulative amount of ingested ALA and LA during two intervals: (i) between the second day after the first significant formula intake (D0) and the fifteenth day (D15); and (ii) between D0 and the first day of the 37th week of post-conception age (W37). The corresponding amounts of ingested ALA and LA were related to ALA and LA levels determined by capillary column gas-liquid chromatography in plasma cholesterol esters at D15 and W37, respectively. RESULTS: ALA in CE was very significantly correlated to D0-D15 and D0-W37 ALA intakes (0.66; P=0.0001 and 0.70; P=0.0001), respectively. LA in CE was weakly correlated to D0-D15 LA intakes (0.03; P=0.01) and whatever the group (human milk or enriched formula) the correlation was lost at W37. CONCLUSION: In preterm infants, ALA in CE can be considered as representative of ALA dietary intakes, whereas LA in CE appears as a poor marker of LA intakes.


Subject(s)
Cholesterol Esters/chemistry , Infant Food , Infant, Premature/metabolism , alpha-Linolenic Acid/administration & dosage , Biological Availability , Biomarkers/analysis , Cholesterol Esters/blood , Chromatography, Gas , Female , Gestational Age , Humans , Infant, Newborn , Infant, Premature/blood , Male , Milk, Human , Statistics as Topic , alpha-Linolenic Acid/analysis , alpha-Linolenic Acid/metabolism
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