ABSTRACT
The distribution of oestrogen and progesterone receptors in the human endometrial basal and functional layer during the normal menstrual cycle was investigated by means of an immunocytochemical technique. A cyclic pattern of receptor distribution was observed. The highest concentration of hormone receptors was observed in the basal layer, in accordance with the idea that this layer is the source of endometrial regeneration.
Subject(s)
Endometrium/metabolism , Menstrual Cycle/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Adult , Cell Nucleus/metabolism , Endometrium/anatomy & histology , Female , Humans , Immunoenzyme Techniques , Observer VariationABSTRACT
The topographical distribution of oestrogen and progesterone receptors in the human endometrium and Fallopian tube was investigated by an immunocytochemical technique. A gradient of positively stained cells was observed: the highest oestrogen and progesterone receptor content was noted in the fundal part of the uterine cavity and the ampullar region of the Fallopian tube. The observed gradient is in keeping with biological and pathological events that occur in the human mullerian tract, e.g. fecundation, implantation and carcinogenesis.
Subject(s)
Endometrium/metabolism , Fallopian Tubes/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Adult , Aged , Cell Nucleus/metabolism , Endometrium/anatomy & histology , Fallopian Tubes/anatomy & histology , Female , Humans , Immunoenzyme Techniques , Middle Aged , Staining and LabelingSubject(s)
Endometrium/chemistry , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Uterine Hemorrhage/metabolism , Uterine Prolapse/metabolism , Adult , Cell Nucleus/chemistry , Cell Nucleus/ultrastructure , Endometrium/ultrastructure , Female , Humans , Menstrual Cycle , Uterine Hemorrhage/pathology , Uterine Prolapse/pathologyABSTRACT
The biologic variation of the embryonic heart rate was investigated by transvaginal ultrasonography during the first trimester of normal (n = 141) and abnormal (n = 29) pregnancies, and the predictive value of a repeatedly diagnosed slow heart rate for pregnancy outcome was determined. The mean heart rate increased from 82 +/- 10.3 beats/min at 5 weeks' gestation to 156 +/- 9.6 beats/min at 9 weeks. A single observation of an abnormally slow heart rate did not necessarily predict subsequent embryonic death. However, a continued decline in embryonic heart activity, observed within a few days' interval, was always associated with a first-trimester abortion.
