ABSTRACT
A 43 year old female was admitted to hospital with severe pulmonary hypertension and cardiogenic shock. She had a two week history of dyspnea only. Resuscitative measures proved unsuccessful and she died ten hours after admission. Post mortem examination indicated that the pulmonary hypertension and right ventricular failure were due to endarteritis secondary to widespread carcinomatous microembolism from adenocarcinoma of the lung.
Subject(s)
Hypertension, Pulmonary/etiology , Neoplastic Cells, Circulating/complications , Pulmonary Embolism/complications , Adult , Female , Humans , Hypertension, Pulmonary/pathology , Lung/pathology , Pulmonary Embolism/pathologyABSTRACT
Twelve patients with chronic airways obstruction took part in a bioavailability study of a sustained-release preparation of theophylline (Nuelin SR). Each patient took a Nuelin SR (250 mg) tablet after an overnight fast and, next day, after a light breakfast. On the third day, six patients took two halves of a 250 mg Nuelin SR tablet after breakfast; six subjects took one-half of a 500 mg Nuelin SR tablet after an overnight fast. There were marked interindividual variations in the plasma theophylline concentrations on all study days. The effect of food was equally variable, and appeared to delay the peak plasma concentration in four subjects; in another four, the peak plasma theophylline concentration occurred earlier, and no change was observed in the remaining four. Overall, no significant differences either in the amount of theophylline absorbed, or in its bioavailability were observed. We suggest that patients should be instructed to take theophylline at the same time every day in relation to food intake; however, theophylline assay is essential for the appropriate use of the drug.
Subject(s)
Eating , Theophylline/administration & dosage , Adult , Aged , Airway Obstruction/drug therapy , Biological Availability , Chronic Disease , Delayed-Action Preparations , Dose-Response Relationship, Drug , Female , Humans , Intestinal Absorption , Male , Middle Aged , Theophylline/blood , Theophylline/metabolism , Time FactorsABSTRACT
The reproducibility of the radioallergosorbent (RAST) inhibition and direct binding assys with mite allergen were investigated in the presence of heterogeneous extracts and non-mite-sensitive atopic sera. Both contain components similar to potential contaminants which would occur in the assay of mite allergen and dust allergen and dust allergen extracts. The standardized inhibition and direct binding assays employed had a day to day (n = 4) coefficient of variation [(s.d. x 100)/mean] of 15% and 24% respectively. The inhibition assay for mite allergen was reproducible in the presence of protein concentrations of added plant, fungal, arthropod and animal extracts in excess of the protein concentrations that occur under the operational mite assay conditions. The mite inhibition assay was also reproducible in the presence of non-mite allergen extracts, with and without additional sera containing IgE specific for the non-mite allergens. The binding of a additional sera containing IgE specific for the non-mite allergens. The binding of a constant quantity of mite allergen to the activated solid phase in the direct binding assay was reproducible in the presence of added bovine serum albumin, and of a fungal or arthropod extract, representing the heterogeneous components of an allergen extract at the concentrations of total protein known to occur in the direct binding assay of mite extracts.
Subject(s)
Allergens/immunology , Antibodies , Mites/immunology , Reagins , Binding Sites , Binding, Competitive , Humans , Radioallergosorbent Test , Serum Albumin, Bovine/pharmacologyABSTRACT
Vertical distribution of pulmonary blood flow (VDPBF) was studied, using radioactive microsphere emboli, in dogs without thoracotomy in the right decubitus position during exposure to lateral (--Gy) accelerations of 1, 2, 4, and 6 G. At all levels of force environment studied, an inverse linear relationship was observed between vertical height in the thorax and pulmonary blood flow (ml/min/ml lung tissue) with a decrease in flow to the most dependent region of the lung despite large increases in intravascular pressures at this site. Changes in blood flow were smallest at the mid-lung level, the hydrostatic "balance point" for vascular and pleural pressures. These force environment-dependent changes in VDPBF are not readily explainable by the Starling resistor analog. Gravity-dependent regional differences in pleural and associated interstitial pressures, plus possible changes in vascular tone resulting from inadequate aeration of blood in the most dependent regions of the lung, probably also affect VDPBF.
Subject(s)
Acceleration , Aerospace Medicine , Gravitation , Pulmonary Circulation , Animals , Dogs , Pleura/blood supply , PostureABSTRACT
Samples of dust were collected from three articles of household bedding in twenty-two Sydney homes during a six-week period beginning in mid December, 1973. Mites, sometimes in large numbers, were found in all homes. The mean number of mites recovered from nursery sheepskins (all woollen) was thirteen times as high as the mean number from other forms of adult or infant bedding sampled. The high mean number in sheepskins is the result of massively high populations in seven of the eighteen skins sampled. Hospital sheepskins were almost almost uniformly mite free. Far fewer mites were collected from cot mattresses which were either vinyl topped or covered with a plastic coverslip than were collected from a cot mattress with a cotton top alone.
