ABSTRACT
Glucocorticoids are not only endogenous hormones but are also administered exogenously as an anti-inflammatory and immunosuppressant for their long-term beneficial and lifesaving effects. Because of their potent anti-inflammatory property and ability to curb the cytokines, they are administered as lifesaving steroids. This property is not only made use of in the cardiovascular system but also in other major organ systems and networks. There is a fine line between their use as a protective anti-inflammatory and a steroid that could cause overuse-induced complications in major organ systems including the cardiovascular system. Studies conducted in the cardiovascular system demonstrate that glucocorticoids are required for growth and development and also for offering protection against inflammatory signals. Excess or long-term glucocorticoid administration could alter cardiac metabolism and health. The endogenous dysregulated state due to excess endogenous glucocorticoid release from the adrenals as seen with Cushing's syndrome or excess exogenous glucocorticoid administration leading to Cushing's-like condition show a similar impact on the cardiovascular system. This review highlights the importance of maintaining a glucocorticoid balance whether it is endogenous and exogenous in regulating cardiovascular health.
ABSTRACT
CASE: A 23-year-old male patient presented with symptomatic, high-grade medial tibial plateau bone marrow edema unresponsive to conservative treatment. After the injection of intralesional viscous bone cement, the patient had resolution of his symptoms and returned to running. CONCLUSION: The use of intralesional viscous bone cement has grown in popularity for the treatment of bone marrow edema in individuals older than 40 years but is uncommon in younger individuals. This case demonstrates that intralesional viscous bone cement may be considered in the treatment of high-grade bone marrow edema in young, active patients who are unresponsive to extensive conservative management.
