Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 37
Filter
1.
Rev Med Liege ; 77(12): 715-721, 2022 Dec.
Article in French | MEDLINE | ID: mdl-36484749

ABSTRACT

Pain is generally perceived as a sensory, emotional and cognitive aggression by the patient who suffers from it and as the enemy that must be defeated by the physician. It may become chronic, and the passage from the acute phase to the chronic phase cannot be explained in a single way. Indeed, multiple factors come into play: biological, psychological and socio-professional. The patient's quality of life then deteriorates and places him/her in a vicious cycle of pain. The assessment of the different components of pain (sensory, emotional, cognitive and behavioural) and its maintenance factors allow for the implementation of therapeutic strategies, both physical and psychological, adapted to every patient. Due to the complexity of chronic pain management, a multidisciplinary strategy is being developed, with a global approach according to the biopsychosocial perspective, including non-pharmacological approaches, with the objective of allowing the patient to be autonomous in the management of his/her symptoms.


La douleur est généralement perçue comme une agression sensorielle, émotionnelle et cognitive par le patient qui en souffre, et comme l'ennemi que le médecin doit vaincre. Elle peut se chroniciser, et le passage de la phase aiguë à la phase chronique ne peut s'expliquer d'une façon unique. En effet, de multiples facteurs biologiques, psychologiques et socio-professionnels entrent en jeu. La qualité de vie du patient se dégrade alors et le place dans un véritable cercle vicieux de la douleur. L'évaluation des différentes composantes de la douleur (sensorielle, émotionnelle, cognitive et comportementale) et de ses facteurs de maintien permet de mettre en place des stratégies thérapeutiques, aussi bien sur le plan physique que psychologique, adaptées à chaque patient. Du fait de la complexité de la prise en charge de la douleur chronique, se développe une méthode pluridisciplinaire, dans une perspective d'approche globale selon le modèle biopsychosocial, incluant également des approches non médicamenteuses avec comme objectif, notamment, de permettre au patient une autonomie dans la gestion de sa symptomatologie.


Subject(s)
Chronic Pain , Female , Humans , Male , Chronic Pain/therapy , Chronic Pain/psychology , Quality of Life , Anxiety
2.
Qual Life Res ; 30(2): 425-436, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33025372

ABSTRACT

PURPOSE: Cancer patients often report low self-esteem and high emotional distress. Two factors seem particularly linked to these symptoms: emotion regulation strategies and mindfulness. The interest of hypnosis and self-care to relieve these symptoms is not well documented. Our randomized controlled trial aimed at assessing the effect of a group intervention combining self-hypnosis and self-care on self-esteem, emotional distress, emotion regulation, and mindfulness abilities of post-treatment cancer patients, as well as investigating the links between these variables. METHODS: One hundred and four patients who had suffered from cancer were randomized into the intervention group (N = 52) and the wait-list control group (N = 52). They had to answer questionnaires before (T1) and after the intervention (T2). Nine men were excluded from the analyses, leading to a final sample of 95 women with cancer. Group-by-time changes were assessed with MANOVA, and associations with self-esteem and emotional distress were investigated with hierarchical linear regression models. RESULTS: Participants in the intervention group (mean age = 51.65; SD = 12.54) reported better self-esteem, lower emotional distress, a decreased use of maladaptive emotion regulation strategies, and more mindfulness abilities after the intervention, compared to the WLCG. This increase in mindfulness explained 33% of the improvement of self-esteem and 41.6% of the decrease of emotional distress in the intervention group. Self-esteem and emotional distress also predicted each other. CONCLUSION: Our study showed the efficacy of our hypnosis-based intervention to improve all the investigated variables. Mindfulness predicted the improvement of self-esteem and emotional distress. The primary impact of our intervention on mindfulness abilities seems to explain, at least in part, its efficacy. Registration: ClinicalTrials.gov (NCT03144154). Retrospectively registered on the 1st of May, 2017.


Subject(s)
Hypnosis/methods , Internet-Based Intervention/trends , Mindfulness/methods , Quality of Life/psychology , Self Care/methods , Self Concept , Stress, Psychological/psychology , Adult , Aged , Female , Humans , Longitudinal Studies , Male , Middle Aged , Neoplasms/psychology , Young Adult
4.
Handb Clin Neurol ; 166: 327-339, 2019.
Article in English | MEDLINE | ID: mdl-31731920

ABSTRACT

Hypnosis is a technique that induces changes in perceptual experience through response to specific suggestions. By means of functional neuroimaging, a large body of clinical and experimental studies has shown that hypnotic processes modify internal (self-awareness) as well as external (environmental awareness) brain networks. Objective quantifications of this kind permit the characterization of cerebral changes after hypnotic induction and its uses in the clinical setting. Hypnosedation is one such application, as it combines hypnosis with local anesthesia in patients undergoing surgery. The power of this technique lies in the avoidance of general anesthesia and its potential complications that emerge during and after surgery. Hypnosedation is associated with improved intraoperative comfort and reduced perioperative anxiety and pain. It ensures a faster recovery of the patient and diminishes the intraoperative requirements for sedative or analgesic drugs. Mechanisms underlying the modulation of pain perception under hypnotic conditions involve cortical and subcortical areas, mainly the anterior cingulate and prefrontal cortices as well as the basal ganglia and thalami. In that respect, hypnosis-induced analgesia is an effective and highly cost-effective alternative to sedation during surgery and symptom management.


Subject(s)
Gyrus Cinguli/physiology , Hypnosis, Anesthetic/methods , Pain Perception/physiology , Animals , Humans , Pain Management/methods
5.
Br J Anaesth ; 121(5): 1059-1064, 2018 Nov.
Article in English | MEDLINE | ID: mdl-30336850

ABSTRACT

BACKGROUND: Propofol use during sedation for colonoscopy can result in cardiopulmonary complications. Intravenous lidocaine can alleviate visceral pain and decrease propofol requirements during surgery. We tested the hypothesis that i.v. lidocaine reduces propofol requirements during colonoscopy and improves post-colonoscopy recovery. METHODS: Forty patients undergoing colonoscopy were included in this randomised placebo-controlled study. After titration of propofol to produce unconsciousness, patients were given i.v. lidocaine (1.5 mg kg-1 then 4 mg kg-1 h-1) or the same volume of saline. Sedation was standardised and combined propofol and ketamine. The primary endpoint was propofol requirements. Secondary endpoints were: number of oxygen desaturation episodes, endoscopists' working conditions, discharge time to the recovery room, post-colonoscopy pain, fatigue. RESULTS: Lidocaine infusion resulted in a significant reduction in propofol requirements: 58 (47) vs 121 (109) mg (P=0.02). Doses of ketamine were similar in the two groups: 19 (2) vs 20 (3) mg in the lidocaine and saline groups, respectively. Number of episodes of oxygen desaturation, endoscopists' comfort, and times for discharge to the recovery room were similar in both groups. Post-colonoscopy pain (P<0.01) and fatigue (P=0.03) were significantly lower in the lidocaine group. CONCLUSIONS: Intravenous infusion of lidocaine resulted in a 50% reduction in propofol dose requirements during colonoscopy. Immediate post-colonoscopy pain and fatigue were also improved by lidocaine. CLINICAL TRIAL REGISTRATION: NCT 02784860.


Subject(s)
Anesthetics, Local/administration & dosage , Colonoscopy/methods , Conscious Sedation/methods , Hypnotics and Sedatives/administration & dosage , Lidocaine/administration & dosage , Propofol/administration & dosage , Adult , Aged , Anesthesia Recovery Period , Double-Blind Method , Fatigue/epidemiology , Fatigue/etiology , Female , Humans , Infusions, Intravenous , Male , Middle Aged , Postoperative Complications/epidemiology , Postoperative Complications/etiology
6.
BMC Med ; 16(1): 134, 2018 08 11.
Article in English | MEDLINE | ID: mdl-30097009

ABSTRACT

The original article [1] contains an error affecting the actigraphy time-stamps throughout the article, particularly in Table 1.

7.
BMC Cancer ; 18(1): 677, 2018 Jun 22.
Article in English | MEDLINE | ID: mdl-29929493

ABSTRACT

BACKGROUND: Prostate and breast cancer can have a lot of negative consequences such as fatigue, sleep difficulties and emotional distress, which decrease quality of life. Group interventions showed benefits to emotional distress and fatigue, but most of these studies focus on breast cancer patients. However, it is important to test if an effective intervention for breast cancer patients could also have benefits for prostate cancer patients. METHODS: Our controlled study aimed to compare the efficacy of a self-hypnosis/self-care group intervention to improve emotional distress, sleep difficulties, fatigue and quality of life of breast and prostate cancer patients. 25 men with prostate cancer and 68 women with breast cancer participated and were evaluated before (T0) and after (T1) the intervention. RESULTS: After the intervention, the breast cancer group showed positive effects for anxiety, depression, fatigue, sleep difficulties, and global health status, whereas there was no effect in the prostate cancer group. We showed that women suffered from higher difficulties prior to the intervention and that their oncological treatments were different in comparison to men. CONCLUSION: The differences in the efficacy of the intervention could be explained by the baseline differences. As men in our sample reported few distress, fatigue or sleep problems, it is likely that they did not improve on these dimensions. TRIAL REGISTRATION: ClinicalTrials.gov ( NCT02569294 and NCT03423927 ). Retrospectively registered in October 2015 and February 2018 respectively.


Subject(s)
Breast Neoplasms/psychology , Fatigue/prevention & control , Hypnosis , Prostatic Neoplasms/psychology , Quality of Life , Self Care , Sleep Wake Disorders/prevention & control , Stress, Psychological/prevention & control , Adult , Aged , Female , Humans , Longitudinal Studies , Male , Middle Aged
8.
Br J Anaesth ; 119(4): 674-684, 2017 Oct 01.
Article in English | MEDLINE | ID: mdl-29121293

ABSTRACT

BACKGROUND: We used functional connectivity measures from brain resting state functional magnetic resonance imaging to identify human neural correlates of sedation with dexmedetomidine or propofol and their similarities with natural sleep. METHODS: Connectivity within the resting state networks that are proposed to sustain consciousness generation was compared between deep non-rapid-eye-movement (N3) sleep, dexmedetomidine sedation, and propofol sedation in volunteers who became unresponsive to verbal command. A newly acquired dexmedetomidine dataset was compared with our previously published propofol and N3 sleep datasets. RESULTS: In all three unresponsive states (dexmedetomidine sedation, propofol sedation, and N3 sleep), within-network functional connectivity, including thalamic functional connectivity in the higher-order (default mode, executive control, and salience) networks, was significantly reduced as compared with the wake state. Thalamic functional connectivity was not reduced for unresponsive states within lower-order (auditory, sensorimotor, and visual) networks. Voxel-wise statistical comparisons between the different unresponsive states revealed that thalamic functional connectivity with the medial prefrontal/anterior cingulate cortex and with the mesopontine area was reduced least during dexmedetomidine-induced unresponsiveness and most during propofol-induced unresponsiveness. The reduction seen during N3 sleep was intermediate between those of dexmedetomidine and propofol. CONCLUSIONS: Thalamic connectivity with key nodes of arousal and saliency detection networks was relatively preserved during N3 sleep and dexmedetomidine-induced unresponsiveness as compared to propofol. These network effects may explain the rapid recovery of oriented responsiveness to external stimulation seen under dexmedetomidine sedation. TRIAL REGISTRY NUMBER: Committee number: 'Comité d'Ethique Hospitalo-Facultaire Universitaire de Liège' (707); EudraCT number: 2012-003562-40; internal reference: 20121/135; accepted on August 31, 2012; Chair: Prof G. Rorive. As it was considered a phase I clinical trial, this protocol does not appear on the EudraCT public website.


Subject(s)
Brain/drug effects , Brain/physiology , Dexmedetomidine/pharmacology , Magnetic Resonance Imaging/methods , Propofol/pharmacology , Sleep/physiology , Adolescent , Adult , Anesthetics, Intravenous/pharmacology , Brain Mapping/methods , Consciousness , Female , Humans , Hypnotics and Sedatives/pharmacology , Image Processing, Computer-Assisted , Male , Neural Pathways/drug effects , Young Adult
9.
Eur J Pain ; 19(10): 1437-46, 2015 Nov.
Article in English | MEDLINE | ID: mdl-25711348

ABSTRACT

BACKGROUND: Chronic pain is considered to be a complex phenomenon, involving an interrelation of biological, psychosocial and sociocultural factors. Currently, no single treatment or therapy can address all aspects of this pathology. In our expert tertiary pain centre, we decide to assess the effectiveness of four treatments for chronic pain classically proposed in our daily clinical work: physiotherapy; psycho-education; physiotherapy combined with psycho-education; and self-hypnosis/self-care learning. METHODS: This study included 527 chronic pain patients, with a mean duration of pain of 10 years. Patients were allocated either to one of the four pre-cited treatment groups or to the control group. Pain intensity, quality of life, pain interference, anxiety and depression were assessed before and after treatment. RESULTS: This study revealed a significant positive effect on pain interference and anxiety in patients included in the physiotherapy combined with psycho-education group, after 20 sessions spread over 9 months of treatment. The most prominent results were obtained for patients allocated to the self-hypnosis/self-care group, although they received only six sessions over a 9-month period. These patients showed significant benefits in the areas of pain intensity, pain interference, anxiety, depression and quality of life. CONCLUSIONS: This clinical report demonstrates the relevance of biopsychosocial approaches in the improvement of pain and psychological factors in chronic pain patients. The study further reveals the larger impact of self-hypnosis/self-care learning treatment, in addition to a cost-effectiveness benefit of this treatment comparative to other interventions.


Subject(s)
Chronic Pain/therapy , Cost-Benefit Analysis , Pain Management/methods , Treatment Outcome , Adult , Aged , Female , Humans , Male , Middle Aged , Pain Clinics/statistics & numerical data , Pain Management/statistics & numerical data , Tertiary Care Centers/statistics & numerical data
10.
Neurophysiol Clin ; 44(4): 343-53, 2014 Oct.
Article in English | MEDLINE | ID: mdl-25306075

ABSTRACT

We here review behavioral, neuroimaging and electrophysiological studies of hypnosis as a state, as well as hypnosis as a tool to modulate brain responses to painful stimulations. Studies have shown that hypnotic processes modify internal (self awareness) as well as external (environmental awareness) brain networks. Brain mechanisms underlying the modulation of pain perception under hypnotic conditions involve cortical as well as subcortical areas including anterior cingulate and prefrontal cortices, basal ganglia and thalami. Combined with local anesthesia and conscious sedation in patients undergoing surgery, hypnosis is associated with improved peri- and postoperative comfort of patients and surgeons. Finally, hypnosis can be considered as a useful analogue for simulating conversion and dissociation symptoms in healthy subjects, permitting better characterization of these challenging disorders by producing clinically similar experiences.


Subject(s)
Brain/physiology , Hypnosis , Nerve Net/physiology , Pain Perception/physiology , Humans , Hysteria/physiopathology
11.
Rev Neurol (Paris) ; 170(10): 630-41, 2014 Oct.
Article in French | MEDLINE | ID: mdl-24952924

ABSTRACT

INTRODUCTION: Interest in studying swallowing disorders in patients with altered consciousness has increased over the past decade. Swallowing deficit is frequently encountered in severe brain-injured patients. STATE OF ART: Results of studies have highlighted different factors such as the delay between the injury and the treatment and the level of consciousness of these patients, as well as the presence or not of tracheotomy, which will determine the feasibility of resuming oral feeding. Nowadays, very few valid and sensitive scales can be used to assess swallowing deficit in patients with disorders of consciousness. The Facial Oral Tract Therapy (FOTT) scale is an inter-professional multidisciplinary approach offering a structured way to evaluate and treat patients with swallowing disorders. In contrast with other scales, patients do not have to follow verbal instructions for the FOTT. PERSPECTIVES: This paper presents a review of existing literature on the assessment and management of swallowing disorders in patients with altered state of consciousness, and a description of the FOTT method. CONCLUSION: The FOTT seems to be an interesting assessment and rehabilitation tool for patients with disorders of consciousness. However, clinical studies are needed to confirm the validity and sensitivity of this technique.


Subject(s)
Consciousness Disorders/complications , Deglutition Disorders/etiology , Deglutition Disorders/diagnosis , Deglutition Disorders/epidemiology , Deglutition Disorders/therapy , Humans , Incidence , Physical Therapy Modalities
12.
Arch Ital Biol ; 150(2-3): 107-21, 2012.
Article in English | MEDLINE | ID: mdl-23165872

ABSTRACT

Using modern brain imaging techniques, new discoveries are being made concerning the spontaneous activity of the brain when it is devoid of attention-demanding tasks. Spatially separated patches of neuronal assemblies have been found to show synchronized oscillatory activity behavior and are said to be functionally connected. One of the most robust of these is the default mode network, which is associated with intrinsic processes like mind wandering and self-projection. Furthermore, activity in this network is anticorrelated with activity in a network that is linked to attention to external stimuli. The integrity of both networks is disturbed in altered states of consciousness, like sleep, general anesthesia and hypnosis. In coma and related disorders of consciousness, encompassing the vegetative state (unresponsive wakefulness syndrome) and minimally conscious state, default mode network integrity correlates with the level of remaining consciousness, offering the possibility of using this information for diagnostic and prognostic purposes. Functional brain imaging is currently being validated as a valuable addition to the standardized behavioral assessments that are already in use.


Subject(s)
Brain Mapping , Brain/physiology , Consciousness/physiology , Models, Neurological , Anesthesia , Animals , Brain/blood supply , Consciousness Disorders/physiopathology , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Neural Pathways/blood supply , Neural Pathways/physiology , Oxygen , Rest , Sleep/physiology
13.
Brain Inj ; 26(12): 1493-9, 2012.
Article in English | MEDLINE | ID: mdl-22725684

ABSTRACT

OBJECTIVES: The aim of this study was to assess the presence of burnout among professional caregivers managing patients with severe brain injury recovering from coma and working in neurorehabilitation centres or nursing homes. METHODS: The Maslach Burnout Inventory was sent to 40 centres involved in the Belgian federal network for the care of vegetative and minimally conscious patients. The following demographic data were also collected: age, gender, profession, expertise in the field, amount of time spent with patients and working place. RESULTS: Out of 1068 questionnaires sent, 568 were collected (53% response rate). Forty-five were excluded due to missing data. From the 523 healthcare workers, 18% (n = 93) presented a burnout, 33% (n = 171) showed emotional exhaustion and 36% (n = 186) had a depersonalization. Profession (i.e. nurse/nursing assistants), working place (i.e. nursing home) and the amount of time spent with patients were associated with burnout. The logistic regression showed that profession was nevertheless the strongest variable linked to burnout. CONCLUSIONS: According to this study, a significant percentage of professional caregivers and particularly nurses taking care of patients in a vegetative state and in a minimally conscious state suffered from burnout. Prevention of burnout symptoms among caregivers is crucial and is expected to promote more efficient medical care of these challenging patients.


Subject(s)
Burnout, Professional , Consciousness Disorders , Health Personnel/psychology , Nursing Homes/statistics & numerical data , Rehabilitation Centers/statistics & numerical data , Adult , Burnout, Professional/diagnosis , Burnout, Professional/psychology , Chronic Disease , Emotions , Female , Health Personnel/statistics & numerical data , Humans , Male , Middle Aged , Surveys and Questionnaires
14.
Brain Res ; 1485: 10-21, 2012 Nov 16.
Article in English | MEDLINE | ID: mdl-22579727

ABSTRACT

Thirteen chronic tinnitus patients and fifteen age-matched healthy controls were studied on a 3T magnetic resonance imaging (MRI) scanner during resting condition (i.e. eyes closed, no task performance). The auditory resting-state component was selected using an automatic component selection approach. Functional connectivity (correlations/anti-correlations) in the extracted network was portrayed by integrating the independent component analysis (ICA) approach with a graph theory method. Tinnitus and control groups showed different graph connectivity patterns. In the control group, the connectivity graph was divided into two distinct anti-correlated networks. The first one encompassed the auditory cortices and the insula. The second one encompassed frontoparietal and anterior cingulate cortices, brainstem, amygdala, basal ganglia/nucleus accumbens and parahippocampal regions. In the tinnitus group, only one of the two previously described networks was observed, encompassing the auditory cortices and the insula. Direct group comparison showed, in the tinnitus group, an increased functional connectivity between auditory cortices and the left parahippocampal region surviving multiple comparisons. We investigated a possible correlation between four tinnitus relevant measures (tinnitus handicap inventory (THI) and tinnitus questionnaire (TQ) scores, tinnitus duration and tinnitus intensity during the scanning session) and the connectivity pattern in the tinnitus population. We observed a significant positive correlation between the beta values of the posterior cingulate/precuneus region and the THI score. Our results show a modified functional connectivity pattern in tinnitus sufferers and highlight the role of the parahippocampal region in tinnitus physiopathology. They also point out the importance of the activity and connectivity pattern of the posterior cingulate cortex/precuneus region to the development of the tinnitus associated distress. This article is part of a Special Issue entitled: Tinnitus Neuroscience.


Subject(s)
Nerve Net/physiopathology , Tinnitus/physiopathology , Acoustic Stimulation , Adult , Aged , Auditory Cortex/physiopathology , Brain/physiopathology , Brain Mapping , Chronic Disease , Data Interpretation, Statistical , Disability Evaluation , Female , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Middle Aged , Neural Pathways/physiopathology , Parahippocampal Gyrus/physiopathology , Principal Component Analysis , Surveys and Questionnaires , Young Adult
15.
Proc Int Conf Image Proc ; 2012: 1257-1260, 2012.
Article in English | MEDLINE | ID: mdl-29937696

ABSTRACT

MRI Diffusion Tensor Imaging (DTI) has been recently proposed as a highly discriminative measurement to detect structural damages in Disorders of Consciousness patients (Vegetative State/Unresponsive Wakefulness Syndrome-(VS/UWS) and Minimally Consciousness State-MCS). In the DTI analysis, certain tensor features are often used as simplified scalar indices to represent these alterations. Those characteristics are mathematically and statistically more tractable than the full tensors. Nevertheless, most of these quantities are based on a tensor diffusivity estimation, the arithmetic average among the different strengths of the tensor orthogonal directions, which is supported on a symmetric linear relationship among the three directions, an unrealistic assumption for severely damaged brains. In this paper, we propose a new family of scalar quantities based on Generalized Ordered Weighted Aggregations (GOWA) to characterize morphological damages. The main idea is to compute a tensor diffusitivity estimation that captures the deviations in the water diffusivity associated to damaged tissue. This estimation is performed by weighting and combining differently each tensor orthogonal strength. Using these new scalar quantities we construct an affine invariant DTI tensor feature using regional tissue histograms. An evaluation of these new scalar quantities on 48 patients (23 VS/UWS and 25 MCS) was conducted. Our experiments demonstrate that this new representation outperforms state-of-the-art tensor based scalar representations for characterization and classification problems.

16.
Acta Anaesthesiol Belg ; 62(3): 161-71, 2011.
Article in English | MEDLINE | ID: mdl-22145259

ABSTRACT

This review aims at defining the link between physiological sleep and general anesthesia. Despite common behavioral and electrophysiological characteristics between both states, current literature suggests that the transition process between waking and sleep or anesthesia-induced alteration of consciousness is not driven by the same sequence of events. On the one hand, sleep originates in sub-cortical structures with subsequent repercussions on thalamo-cortical interactions and cortical activity. On the other hand, anesthesia seems to primarily affect the cortex with subsequent repercussions on the activity of sub-cortical networks. This discrepancy has yet to be confirmed by further functional brain imaging and electrophysiological experiments. The relationship between the observed functional modifications of brain activity during anesthesia and the known biochemical targets of hypnotic anesthetic agents also remains to be determined.


Subject(s)
Anesthesia, General , Sleep/physiology , Arousal/drug effects , Arousal/physiology , Consciousness , Electroencephalography , Humans , Ketamine/pharmacology , Sleep/drug effects
17.
Prog Brain Res ; 193: 309-22, 2011.
Article in English | MEDLINE | ID: mdl-21854971

ABSTRACT

Resting state fMRI (functional magnetic resonance imaging) acquisitions are characterized by low-frequency spontaneous activity in a default mode network (encompassing medial brain areas and linked to self-related processes) and an anticorrelated "extrinsic" system (encompassing lateral frontoparietal areas and modulated via external sensory stimulation). In order to better determine the functional contribution of these networks to conscious awareness, we here sought to transiently modulate their relationship by means of hypnosis. We used independent component analysis (ICA) on resting state fMRI acquisitions during normal wakefulness, under hypnotic state, and during a control condition of autobiographical mental imagery. As compared to mental imagery, hypnosis-induced modulation of resting state fMRI networks resulted in a reduced "extrinsic" lateral frontoparietal cortical connectivity, possibly reflecting a decreased sensory awareness. The default mode network showed an increased connectivity in bilateral angular and middle frontal gyri, whereas its posterior midline and parahippocampal structures decreased their connectivity during hypnosis, supposedly related to an altered "self" awareness and posthypnotic amnesia. In our view, fMRI resting state studies of physiological (e.g., sleep or hypnosis), pharmacological (e.g., sedation or anesthesia), and pathological modulation (e.g., coma or related states) of "intrinsic" default mode and anticorrelated "extrinsic" sensory networks, and their interaction with other cerebral networks, will further improve our understanding of the neural correlates of subjective awareness.


Subject(s)
Brain/anatomy & histology , Brain/physiology , Hypnosis , Neural Pathways/anatomy & histology , Neural Pathways/physiology , Adolescent , Awareness/physiology , Female , Humans , Magnetic Resonance Imaging/methods , Male , Young Adult
18.
Prog Brain Res ; 193: 323-33, 2011.
Article in English | MEDLINE | ID: mdl-21854972

ABSTRACT

Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.


Subject(s)
Consciousness Disorders/physiopathology , Consciousness/physiology , Hemispherectomy , Neuroimaging/methods , Adolescent , Brain/pathology , Brain/physiopathology , Brain Injuries/pathology , Brain Injuries/physiopathology , Consciousness Disorders/pathology , Diagnostic Imaging/methods , Diffusion Tensor Imaging , Electroencephalography , Humans , Magnetic Resonance Imaging , Male , Neuropsychological Tests , Persistent Vegetative State/pathology , Persistent Vegetative State/physiopathology , Positron-Emission Tomography , Young Adult
19.
J Neurol ; 258(6): 1058-65, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21221625

ABSTRACT

Previous European surveys showed the support of healthcare professionals for treatment withdrawal [i.e., artificial nutrition and hydration (ANH) in chronic vegetative state (VS) patients]. The recent definition of minimally conscious state (MCS), and possibly research advances (e.g., functional neuroimaging), may have lead to uncertainty regarding potential residual perception and may have influenced opinions of healthcare professionals. The aim of the study was to update the end-of-life attitudes towards VS and to determine the end-of-life attitudes towards MCS. A 16-item questionnaire related to consciousness, pain and end-of-life issues in chronic (i.e., >1 year) VS and MCS and locked-in syndrome was distributed among attendants of medical and scientific conferences around Europe (n = 59). During a lecture, the items were explained orally to the attendants who needed to provide written yes/no responses. Chi-square tests and logistic regression analyses identified differences and associations for age, European region, religiosity, profession, and gender. We here report data on items concerning end-of-life issues on chronic VS and MCS. Responses were collected from 2,475 participants. For chronic VS (>1 year), 66% of healthcare professionals agreed to withdraw treatment and 82% wished not to be kept alive (P < 0.001). For chronic MCS (>1 year), less attendants agreed to withdraw treatment (28%, P < 0.001) and wished not to be kept alive (67%, P < 0.001). MCS was considered worse than VS for the patients in 54% and for their families in 42% of the sample. Respondents' opinions were associated with geographic region and religiosity. Our data show that end-of-life opinions differ for VS as compared to MCS. The introduction of the diagnostic criteria for MCS has not substantially changed the opinions on end-of-life issues on permanent VS. Additionally, the existing legal ambiguity around MCS may have influenced the audience to draw a line between expressing preferences for self versus others, by implicitly recognizing that the latter could be a step on the slippery slope to legalize euthanasia. Given the observed individual variability, we stress the importance of advance directives and identification of proxies when discussing end-of-life issues in patients with disorders of consciousness.


Subject(s)
Attitude of Health Personnel , Attitude to Death , Persistent Vegetative State/psychology , Adolescent , Adult , Advance Directives , Aged, 80 and over , Consciousness , Europe , Female , Health Surveys , Humans , Logistic Models , Male , Middle Aged , Religion , Retrospective Studies , Surveys and Questionnaires , Young Adult
20.
Rev Neurol (Paris) ; 166(8-9): 675-82, 2010.
Article in French | MEDLINE | ID: mdl-20223495

ABSTRACT

INTRODUCTION: Difficulties in detecting bedside signs of consciousness in non-communicative patients still lead to a high rate of misdiagnosis illustrating the need to employ standardized behavioral assessment scales. STATE OF ART: The Sensory Modality Assessment and Rehabilitation Technique (SMART) is a behavioral assessment scale of consciousness that assesses responses to multimodal sensory stimulation in disorders of consciousness. These stimulations can also be considered to have therapeutic value. PERSPECTIVES: We here review the different components and use of the SMART assessment and discuss its validity, reliability, and robustness in clinical practice. The scale has a high intra- and inter-observer reliability thanks to a detailed procedure description. However, in the absence of objective gold standards in the assessment of consciousness, it is currently difficult to make strong claims about its validity. A comparison between SMART and other standardized and validated coma-scales is proposed. CONCLUSION: In our view, SMART is an interesting tool for monitoring patients with altered states of consciousness subsequent to coma. Currently, we await studies on its concurrent validity as compared to other validated behavioral assessment scales and on the effect of SMART stimulations on patient outcome.


Subject(s)
Behavioral Symptoms/diagnosis , Consciousness Disorders/diagnosis , Severity of Illness Index , Behavioral Symptoms/etiology , Behavioral Symptoms/psychology , Coma/diagnosis , Coma/psychology , Communication , Consciousness Disorders/complications , Consciousness Disorders/psychology , Humans , Orientation , Perception , Reflex, Abnormal , Sensitivity and Specificity , Trauma Severity Indices
SELECTION OF CITATIONS
SEARCH DETAIL
...