ABSTRACT
BACKGROUND: Halo nevi are often considered benign, and the possibility of malignancy is not always clear to practitioners. We present two case reports suggesting that a halo nevus appearance can be seen in melanoma, even in young adults. A literature search for halo nevi revealing melanoma shows that this is a very rare condition. Case presentation. This report of two young patients indicates the importance of obtaining a detailed history to detect warning signs such as itching, pain, spontaneous bleeding, and previous alterations according to the patient, including a previously totally black colour in an already fully regressed melanoma. CONCLUSIONS: The risk of a halo nevus being malignant is higher if there is only one unique halo nevus and no personal or familial history of vitiligo. We postulate that a regressing atypical nevus or a regressing melanoma may be induced by an immunologic reaction as halo nevus type of clinical picture.
ABSTRACT
It is widely accepted that chronic burn wounds may lead to the development of various malignant skin tumors. Deep stage 3 burned areas may facilitate deeper carcinogenesis. Deep tissues are probably less subject to severe insult than is the epithelial layer during physical insult, suggesting that soft tissues transform to a lesser extent during the late stages of tumoral development as in an immunocompromised district with altered local immune defense with both cellular and humoral defense affected. Most authors claim that tumors are almost squamous cell carcinomas, although other types of malignancies such as basal cell carcinoma and, to a lesser extent, melanoma can also be seen. However, malignant transformation of cutaneous soft tissue in a burn insult area has rarely been described. Similarly, burn-induced tumors of histiocytic origin have been reported in few cases and osteosarcoma only in two case reports. Here, we report a patient case suffering from severe large stage 3 burn after-effects on the leg. Fifty-five years after the injury, this patient developed a large extraosseous osteosarcoma on the scar.
ABSTRACT
Onychomatricoma is a rare and benign tumour of the nail matrix but originates rarely from the ventral portion of the proximal nail fold. This tumour is characterised by fingerlike projections that invade the nail plate. This lesion, of unknown aetiology, is typically asymptomatic with slow progression. Localisation on the finger is the most frequently described. We report the case of a 68-year-old woman who has an onychomatricoma in an unusual location, the fifth toe of the left foot. Due to its clinical appearance, the tumour can be confused with and treated as onychomycosis. However, if it is resistant to an oral antifungal well behaved treatment, one must consider onychomatricoma diagnosis.
ABSTRACT
This is a case report of a Pott's puffy tumor, characterized by a subperiosteal abscess associated with frontal bone osteomyelitis, as a consequence of a frontal sinusitis, in a 15-year-old boy. Pott's puffy tumor is a rare condition usually seen as a complication of frontal sinusitis and more commonly described in children. Given that, superficial temporal artery pseudoaneurysms might be interpreted as a cyst or lipoma, it is imperative that physicians be aware of their presentation.
Subject(s)
Brain Abscess/etiology , Frontal Sinusitis/complications , Fusobacterium Infections/diagnosis , Osteomyelitis/etiology , Acne Vulgaris/diagnosis , Adolescent , Amoxicillin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Anticonvulsants/therapeutic use , Brain Abscess/diagnosis , Brain Abscess/microbiology , Clavulanic Acid/therapeutic use , Drainage , Frontal Sinusitis/drug therapy , Fusobacterium/drug effects , Fusobacterium Infections/drug therapy , Fusobacterium Infections/etiology , Fusobacterium Infections/surgery , Humans , Male , Methylprednisolone/therapeutic use , Methylprednisolone Hemisuccinate/therapeutic use , Osteomyelitis/diagnosis , Osteomyelitis/microbiology , Peptostreptococcus/drug effects , Treatment Outcome , Valproic Acid/therapeutic useABSTRACT
A 64-year-old man with a pulmonary transplant developed diffuse verrucae vulgares of the neck. After the failure of multiple cryotherapy treatments, 3 sessions of photodynamic therapy resulted in rapid therapeutic clinical success. This moderately painful and well-tolerated treatment is reproducible and can be very useful in treating papillomavirus infections in the immunosuppressed patient.
Subject(s)
Antineoplastic Agents/adverse effects , Granuloma, Pyogenic/chemically induced , Nail Diseases/chemically induced , Taxoids/adverse effects , Aged , Carcinoma, Non-Small-Cell Lung/drug therapy , Docetaxel , Female , Granuloma, Pyogenic/microbiology , Humans , Klebsiella Infections , Lung Neoplasms/drug therapy , Nail Diseases/microbiology , Staphylococcal Infections , Treatment OutcomeABSTRACT
Belgium has been confronted to cases of paedophilia for years. It seems adequate to suggest some guidelines in cases of a child or a teenager diagnosed with ano-genital warts during a consultation. They are not always the consequence of sexual abuse. Three contaminations are possible: ante natal and peri natal (in utero or during delivery), by direct contact (auto or hetero inoculation), through sexual contact. This trusted practitioners to handle this unusual situation from the child protection, to multidisciplinary management and judicial prosecution against suspect. When using some different way to know what kind of HPV type; it's possible to give some information about transmission and it's possible to do confrontations with the results of the lesions' suspect. It is also interesting to identify very highs oncogenic potential HPV for the survey's patient. Finally the most important is to know that the most recurrences result into reactivations from infra-clinically infections and are not new contaminations. It is important do not drop a new suspicion through hypothetic contaminator.
Subject(s)
Child Abuse, Sexual/diagnosis , Condylomata Acuminata , Genital Diseases, Female/epidemiology , Genital Diseases, Male/epidemiology , Practice Guidelines as Topic , Adolescent , Belgium/epidemiology , Child , Child, Preschool , Condylomata Acuminata/epidemiology , Condylomata Acuminata/etiology , Condylomata Acuminata/therapy , Condylomata Acuminata/virology , Female , Genital Diseases, Female/therapy , Genital Diseases, Female/virology , Genital Diseases, Male/therapy , Genital Diseases, Male/virology , Humans , Male , Papillomaviridae/isolation & purificationABSTRACT
Arsenic is an ubiquitary element which has been widely used for centuries in different fields such as medicine, agriculture or industry. Acute or chronic exposure to As can lead to various dermatological and systemic disorders with a possibe latency over decades. The dermatological signs of As intoxication are important to detect since one of the potential complications is carcinoma.
Subject(s)
Arsenic Poisoning/diagnosis , Arsenic Poisoning/complications , Arsenites/adverse effects , Carcinoma, Squamous Cell/etiology , Chronic Disease , Diagnosis, Differential , Female , Hand/pathology , Humans , Keratoderma, Palmoplantar/etiology , Middle Aged , Potassium Compounds/adverse effects , Psoriasis/drug therapy , Skin Neoplasms/etiologyABSTRACT
We report the case of a 33-year-old patient who had had insulin-dependent diabetes mellitus (IDDM) since he was 11 months old, and who presented with major perforating necrobiosis lipoidica (PNL) complicated by a well-differentiated epidermoid carcinoma. PNL is a rare clinical form of NL, always associated with diabetes. Only seven cases have been reported to date in the literature, and to the best of our knowledge, an association of epidermoid carcinoma and PNL has never been described. The development of a tumoral transformation on a classical NL plaque has only been described 12 times. The presence of an epidermoid carcinoma on a weakened background with permanent ulceration suggests that early surgical excision of the tumour and of the NL followed by a skin graft might be the treatment of choice. Radiotherapy seems to be a poor therapeutic option.
Subject(s)
Carcinoma, Squamous Cell/diagnosis , Diabetes Complications/diagnosis , Leg Dermatoses/diagnosis , Necrobiosis Lipoidica/diagnosis , Adult , Carcinoma, Squamous Cell/complications , Diabetes Mellitus, Type 1/pathology , Fatal Outcome , Humans , Leg Dermatoses/complications , Male , Necrobiosis Lipoidica/complicationsABSTRACT
Vulvar lichen sclerosus is a frequent mucocutaneous disease especially affecting 50 to 60 year-old women but with a possible onset at very young age. Symptoms are most disabling including pruritus and dyspareunia. Vulvar mucosa gradually becomes more white and atrophied. Degeneration into epidermoid carcinoma is possible. Treatment only consists of topical corticosteroids.