ABSTRACT
It is stated that therapeutic effect of humoral factors isolated from the cattle spleen is associated with its influence on alpha 2-macroglobulin (alpha 2-MG) performing a protective function. The results obtained permit recommending the isolated preparations to increase total resistivity of the organism under irradiation.
Subject(s)
Radiation Injuries, Experimental/prevention & control , Radiation Protection/methods , Thymopoietins/pharmacology , Thymus Hormones/pharmacology , alpha-Macroglobulins/biosynthesis , Animals , Cattle , Female , Male , Mice , Mice, Inbred C57BL , Radiation-Protective Agents , Thymopoietins/administration & dosage , Time FactorsABSTRACT
Patients with diabetes showed disorders of the dynamic balance of the system of protease inhibitors of the blood serum and lymphocytes which depend on the type of diabetes, severity and compensation of diabetes. Disorders of the proteolytic systems were accompanied by changes of hemostasis. It is of importance to control the above disorders in the complex treatment of diabetes mellitus and its complications.
Subject(s)
Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 2/blood , Hemostasis , Serine Endopeptidases/blood , Adolescent , Adult , Chronic Disease , Humans , Lymphocytes/enzymology , Middle Aged , Serine Proteinase Inhibitors/bloodABSTRACT
The role of serine proteases of trypsin type was shown in the pathogenesis of autoimmune processes and nonspecific reactivity in diabetes mellitus. The use of protease blockers and thymic hormonal factors was proposed for patients suffering from diabetes mellitus with changed immunological reactivity.
Subject(s)
Diabetes Mellitus/blood , Lymphocytes/enzymology , Protease Inhibitors/therapeutic use , Serine Endopeptidases/blood , Adolescent , Adult , Animals , Aprotinin/therapeutic use , Female , Humans , Male , Mice , Mice, Inbred C57BL , Middle Aged , Spleen/cytology , Thymus Gland/cytologySubject(s)
Carbohydrates/blood , Diabetic Angiopathies/blood , Lipids/blood , Adult , Chronic Disease , Humans , Middle Aged , VeinsABSTRACT
A modified method for isolation of the calf thymus hormone thymopoetin has been developed. For hormone purification high-speed multi-stage centrifugation and gel-filtration on sefadexes were used instead of filtration. The thymus hormonal factor was identified on the basis of its ability to block neuromuscular transmission.