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1.
Arch Esp Urol ; 62(2): 103-8, 2009 Mar.
Article in Spanish | MEDLINE | ID: mdl-19448276

ABSTRACT

BACKGROUND: Many studies have investigated the association between obesity, adipose tissue-derived factors (leptin and adiponectin) and prostate cancer (CaP) but the results are still inconsistent. METHODS: The aim of this study was to carry out a comprehensive review of the existing evidence about the role of leptin and adiponectin in prostate carcinogenesis and to provide an overview of it. RESULTS: Recent evidence suggests that leptin may play a rol in prostate cancer progression, while adiponectin may act as an "antiprostatic cancer" adipokine. CONCLUSIONS: Obesity may promote the progression of established prostate cancer and and adipokines may provide a molecular mechanism whereby obesity exerts its effects on prostate tumour biology.


Subject(s)
Adiponectin/physiology , Leptin/physiology , Prostatic Neoplasms/etiology , Humans , Male
2.
Arch. esp. urol. (Ed. impr.) ; 62(2): 103-108, mar. 2009. ilus
Article in Spanish | IBECS | ID: ibc-60014

ABSTRACT

OBJETIVO: Numerosos estudios han investigado la asociación entre la obesidad, las sustancias secretadas por el tejido adiposo (leptina y adiponectina) y el cáncer de próstata (CaP), aunque los resultados no han sido concluyentes. El objetivo del presente trabajo es realizar una revisión bibliográfica sobre el rol de la leptina y la adiponectina en el desarrollo del CaP.MÉTODOS: Se realizó una búsqueda bibliográfica y lectura compresiva de artículos relacionados con “leptina”, “adiponectina”, “obesidad” y “cáncer de próstata” en Pubmed y revistas científicas; y se efectuó una breve descripción sobre el tema.RESULTADOS: Estudios recientes indican que el tejido adiposo y las diferentes sustancias que éste secreta, denominadas adipoquinas, podrían promover o prevenir el desarrollo del CaP. La leptina tendría un efecto promotor del tumor; mientras que la adiponectina tendría un efecto protector.CONCLUSIÓN: La obesidad podría influenciar la carcinogénesis prostática mediante un mecanismo molecular en el que participarían las adipoquinas(AU)


OBJECTIVES: Many studies have investi-gated the association between obesity, adipose tissue-derived factors (leptin and adiponectin) and prostate cancer (CaP) but the results are still inconsistent.METHODS: The aim of this study was to carry out a comprehensive review of the existing evidence about the role of leptin and adiponectin in prostate carcinoge-nesis and to provide an overview of it.RESULTS: Recent evidence suggests that leptin may play a rol in prostate cancer progression, while adiponectin may act as an “anti- prostatic cancer” adipokine.CONCLUSIONS: Obesity may promote the progression of established prostate cancer and and adipokines may provide a molecular mechanism whereby obesity exerts its effects on prostate tumour biology(AU)


Subject(s)
Humans , Male , Prostatic Neoplasms/enzymology , Prostatic Neoplasms/epidemiology , Leptin/administration & dosage , Leptin/agonists , Adiponectin/administration & dosage , Adiponectin/metabolism , Adipose Tissue/enzymology , Adipokines/biosynthesis , Leptin/chemical synthesis , Leptin/metabolism , Leptin/therapeutic use , Adiponectin/analysis , Obesity/complications
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