ABSTRACT
We describe two cases with sarcoidosis affecting upper respiratory tract. This uncommon localization, may occur in patients with previously diagnosed sarcoidosis, but it may be the first or the only manifestation of the disease. A severe upper airway obstruction can occur, necessitating urgent tracheostomy. Systemic corticosteroid therapy is the treatment of choice in most cases.
Subject(s)
Respiratory Tract Diseases/diagnosis , Sarcoidosis/diagnosis , Diagnosis, Differential , Female , Humans , Middle Aged , Respiratory Tract Diseases/physiopathology , Sarcoidosis/physiopathology , Time FactorsABSTRACT
The authors report the observation of a lethal midline granuloma in a 43 years old man, at first seen with repeated left sinusitis disease, the histo-pathological study of a biopsy of the external middle third of the left side of the nose made the diagnosis of midline lethal granuloma, classically called Stewart granuloma by french authors. General Medical Investigations to find some peripheral extension, done in specialized services were negative, Epstein Barr DNA was not found by the immuno-histochemical investigations and so don't prove the filiation of this case with angiocentric T cell immunoproliferative lesion. By the light of this observation and of a literature review, the authors debate about the difficulty of diagnosis and about the relations with the other granulomatosis lesions of the face, non Hodgkins' lymphoma and angiocentric T cell immuno-proliferative lesions.
Subject(s)
Granuloma, Lethal Midline/complications , Lymphoma, T-Cell/complications , Nose Neoplasms/complications , Paranasal Sinus Neoplasms/complications , Adult , Granuloma, Lethal Midline/pathology , Humans , Lymphoma, T-Cell/pathology , Male , Nose Neoplasms/pathology , Paranasal Sinus Neoplasms/pathologyABSTRACT
The authors report three cases of Median Cleft of the upper lip, a clinical entity really deserving the term of "hare lip", a very ancient denomination who dates back to the Tang Dynasty and unfairly used to describe the usual lateral clefts of the lip. The denominations of "true" and "false" median cleft lips recovering respectively such different embryopathic realities as clefts of the median element with varying degrees of vertical separation and as agenesis of the fronto-nasal process accompanied with cerebral anomalies are no more used now. Median clefts of the upper lip can be included in the "neurocristopathies" by less or more precocious dysneurulation of the fronto-nasal process creating anomalies from various single midline defects of the upper lip of our three cases, to associated midline defects like in the Median Cleft face syndrome (fronto-nasal dysplasia) described by De Myer and Sedano to holoprosencephaly (arhinencephaly), which are rarely associated.