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Modification of lipogenesis in the isolated hamster flank organ through clofibric acid.
Venencie, P Y; Vantrou-Delaunay, M; Bougaret, S; Chaumeil, J C.
Skin Pharmacol ; 8(4): 203-6, 1995.
Article in English | MEDLINE | ID: mdl-7488397

ABSTRACT

The hamster flank organ model was used to measure the effects of clofibric acid on the in vitro uptake of sodium [1-14C] acetate into lipids. Clofibric acid produces a dose-dependent inhibition of lipogenesis in the hamster flank organ in vitro.


Subject(s)
Clofibric Acid/pharmacology , Hypolipidemic Agents/pharmacology , Lipids/biosynthesis , Sebaceous Glands/metabolism , Acetates/metabolism , Animals , Cricetinae , Dimethyl Sulfoxide/pharmacology , Ethanol/pharmacology , In Vitro Techniques , Male , Mesocricetus , Sebaceous Glands/drug effects
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