Contribution to the early diagnosis of diabetes mellitus.

The authors present the results of an investigation for diabetes mellitus (DM), in a selected group of 9,901 persons at high risk for the disease, using oral glucose tolerance test (OGTT). In the group investigated they included 4,753 diabetic blood relatives, 4,123 obese patients and 935 women who delivered big babies. The percentage of diagnosed DM was 30.58 for the entire group, with variations between: 39.47 in the obese, 27.27 in women with macrosomia, and 23.35% in the diabetic blood relatives. The results showed the value of OGTT as a diagnostic tool, the importance of early diagnosis and the necessity of careful long time follow-up of the newly diagnosed diabetics.

Lipidogram structure and the exercise capacity in obesity.

30 women, aged between 21 and 52, with 2nd and 3rd grade obesity were investigated. Total lipids, total cholesterol, HDL cholesterol, tryglicerides and lipoprotein electrophoretic fractions from blood plasma were determined. The subjects were tested at a submaximal exercise intensity of a triangular type on the ergometric bicycle, starting from zero Watt to a progressive increasing load of 10 Watt/min., till the maximal optimal heart rate was reached. The heart rate, blood pressure, CO2 produced and O2 consumption were determined at rest, during exercise at each step, and in the recovery period, predicted the maximum oxygen consumption, evaluated by the Astrand method. The subjective sensation concerning the effort was taken into consideration, based on the modified Borg scale and adaptability to exercise was evaluated, expressed by the "adaptability coefficient" (AC). The index of correlation between the plasma lipid fractions and AC was also determined. Lipidograma showed modifications of 94.44 percent of which 27.77 percent belonged to type IV of H-LP. AC diminished to 50.2 percent as opposed to the ideal values; the maximum oxygen consumption was diminished as well, with an important functional aerobic impairment. There was not found a statistically significant correlation between plasma lipid fractions and AC.