ABSTRACT
UNLABELLED: Thrombocytosis in infants exposed in-utero to illicit drugs has been associated to methadone exposure. Although is reported to present in the first two weeks, few studies address its duration and timing of resolution. This study evaluated the presence, duration, and complications of thrombocytosis in newborns exposed to illicit drugs. METHODS: A retrospective review of medical records of newborns with intrauterine drug exposure admitted to the San Juan City Hospital from 1999 to 2001 was performed. RESULTS: Thirty-one newborns were included. Eighty-seven percent (87%) presented abstinence syndrome. Of these, 96% presented thrombocytosis. All infants exposed to methadone presented thrombocytosis and 75% of those exposed to heroin and cocaine. Thrombocytosis presented at ten days of life with a median resolution at 26 days. CONCLUSIONS: In this group of newborns, thrombocytosis was associated to intrauterine exposure to methadone, heroin, and cocaine. Thrombocytosis presented at ten days of life and resolution was seen in three to 4 weeks without complications observed.
Subject(s)
Pregnancy Complications , Substance-Related Disorders , Thrombocytosis/epidemiology , Female , Humans , Infant, Newborn , Male , Pregnancy , Retrospective StudiesABSTRACT
48 infantes nacidos a término en un centro terciario en Puerto Rico en el año 1986 se evaluaron prospectivametne desde el nacimiento y completaron una evaluación de desarrollo neurpsicológico con la prueba de índice de desarrollo mental de Bayley - Mental Development Index (MDI). Todos los infantes estaban libres de complicaciones perinatales y enfermedades crónicas por evaluación clínica. Se compararon 25 infantes a término con retraso en crecimiento intrauterino con 23 infantes adecuados para edad gestacional. De los ingantes con retraso en crecimiento intrauterino, 14 fueron controles y 11 sufrieron intervención mientras que los infantes adecuados para edad gestacional sirvieron de control en su totalidad. Se evaluó la relación materno-infantil en la vista al mes, encontrándose que ninguno de los infantes intervenidos en MDI normales o cercano a lo normal. Otras relaciones y posibles explicaciones se discuten en el artículo
