1.
J Biotechnol
; 88(1): 1-10, 2001 Jun 01.
Article
in English
| MEDLINE
| ID: mdl-11377760
ABSTRACT
Pimprinine, an extracellular alkaloid has been isolated from the culture filtrate of Streptomyces CDRIL-312. Pimprinine was subsequently purified using silica gel column chromatography and also by preparatory thin layer chromatography. Some physicochemical properties, antimicrobial activities (in-vitro) and pharmacological activities of pimprinine were studied. Pimprinine showed promising anticonvulsant activity in both minimum and maximum electric seizure threshold test in mice. Its anticonvulsant activity is very much comparable to that of phenyl hydantion sodium. Pimprinine also inhibited effectively tremorine-induced tremors and analgesia in mice.
Subject(s)
Anticonvulsants/pharmacology , Oxazoles/metabolism , Oxazoles/pharmacology , Phenytoin/metabolism , Phenytoin/pharmacology , Streptomyces/metabolism , Animals , Biotechnology/methods , Chromatography, Thin Layer/methods , Dose-Response Relationship, Drug , Fermentation , Lethal Dose 50 , Mice , Mice, Inbred Strains , Microbial Sensitivity Tests , Oxazoles/isolation & purification , Phenytoin/isolation & purification , Respiratory Insufficiency/chemically induced , Seizures/drug therapy , Toxicity Tests , Tremor/chemically induced , Tremor/drug therapy , Tremorine/toxicity
2.
J Postgrad Med
; 27(3): 159-62, 1981 Jul.
Article
in English
| MEDLINE
| ID: mdl-7299704
Subject(s)
Respiratory Tract Infections/drug therapy , Sulfadiazine/therapeutic use , Sulfamethoxazole/therapeutic use , Trimethoprim/therapeutic use , Adolescent , Adult , Aged , Child , Double-Blind Method , Drug Combinations , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Random Allocation
3.
J Postgrad Med
; 27(3): 154-8, 1981 Jul.
Article
in English
| MEDLINE
| ID: mdl-7028981