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Exp Dermatol ; 4(2): 82-8, 1995 Apr.
Article in English | MEDLINE | ID: mdl-7640880

ABSTRACT

Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.


Subject(s)
Benzylidene Compounds/pharmacology , Catechols/pharmacology , Dermatologic Agents/pharmacology , ErbB Receptors/antagonists & inhibitors , Keratinocytes/drug effects , Nitriles/pharmacology , Psoriasis/pathology , Receptor Protein-Tyrosine Kinases/antagonists & inhibitors , Tyrphostins , Cells, Cultured/drug effects , Female , Humans , Male
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