ABSTRACT
AIM: To determine the clinical, sociodemographic, and treatment characteristics of inflammatory bowel disease (IBD) in a Colombian population register. METHODS: A descriptive, analytic, observational, cross-sectional, multicenter study on patients with IBD from 17 hospital centers in 9 Colombian cities was conducted. RESULTS: A total of 2,291 patients with IBD were documented, 1,813 (79.1%) of whom presented with ulcerative colitis (UC), 456 (19.9%) with Crohn's disease (CD), and 22 with IBD unclassified (0.9%). The UC/CD ratio was 3.9:1. A total of 18.5% of the patients with UC and 47.3% with CD received biologic therapy. Patients with extensive UC had greater biologic therapy use (OR = 2.78, 95% CI: 2.10-3.65, p = 0.000), a higher surgery rate (OR = 5.4, 95% CI: 3.5-8.3, p = 0.000), and greater frequency of hospitalization (OR = 4.34, 95% CI: 3.47-5.44, p = 0.000). Patients with severe UC had greater biologic therapy use (OR = 5.04, 95% CI: 3.75-6.78, p = 0.000), a higher surgery rate (OR = 8.64, 95% CI: 5.4-13.78, p = 0.000), and greater frequency of hospitalization (OR = 28.45, 95% CI: 19.9-40.7, p = 0.000). CD patients with inflammatory disease behavior (B1) presented with a lower frequency of hospitalization (OR = 0.12, 95% CI: 0.07-0.19, p = 0.000), a lower surgery rate (OR = 0.08, 95% CI: 0.043-0.15, p = 0.000), and less biologic therapy use (OR = 0.26, 95% CI: 0.17-0.41, p = 0.000). CONCLUSION: In Colombia, there is a predominance of UC over CD (3.9:1), as occurs in other Latin American countries. Patients with extensive UC, severe UC, or CD with noninflammatory disease behavior (B2, B3) have a worse prognosis.
ABSTRACT
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Subject(s)
Humans , Male , Infant, Newborn , Dacryocystitis/complications , Mucocele/complications , Respiratory Distress Syndrome, Newborn/etiology , Diagnosis, DifferentialABSTRACT
Solid experimental evidence indicates that EBA-175 is used as a ligand by the Plasmodium falciparum merozoite to bind to human RBC, via different binding processing fragments. Using synthetic peptides and specific receptor-ligand interaction methodology, we have identified 6 high-activity binding sequences from the EBA-175 CAMP strain; peptide 1758 (KSYGTPDNIDKNMSLIHKHN), located in the so-called region I for which no binding activity has been reported before, peptides 1779 (NIDRIYDKNLLMIKEHILAI) and 1783 (HRNKKNDKLYRDEWWKVIKK), located in region II, in a sub-region known as 5' Cys F2, previously reported as being a binding region, and peptides 1814 (DRNSNTLHLKDYRNEENERH), 1815 (YTNQNINISQERDLQKHGFH) and 1818 (NNNFNNIPSRYNLYDKKLDL), in region III-V where antibodies inhibit merozoite invasion of erythrocytes. The affinity constants were between 60 and 180 nM and the critical amino acids involved in the binding were identified. The binding of these peptides to enzyme-treated RBC was analysed; binding of peptide 1814, located in the III-V region, was found to be sialic acid dependent. Some of these high binding peptides were able to inhibit in vitro merozoite invasion and to block the binding of recombinant RII-EBA to RBC. Several of these peptides are located in regions recognized by protective immune clusters of merozoites (ICMs) eluted antibodies.
Subject(s)
Antigens, Protozoan , Carrier Proteins/chemistry , Erythrocytes/parasitology , Malaria, Falciparum/parasitology , Plasmodium falciparum/chemistry , Protozoan Proteins/chemistry , Amino Acid Sequence , Animals , Binding, Competitive , Carrier Proteins/physiology , Erythrocytes/chemistry , Hematocrit , Humans , Iodine Radioisotopes , Ligands , Molecular Sequence Data , Peptide Fragments/chemical synthesis , Protozoan Proteins/physiology , Scintillation CountingSubject(s)
Child , Chronic Disease , Age Factors , Child, Institutionalized , Child, Preschool , Emotions , Female , Humans , Male , Parent-Child Relations , Psychology, Child , Sibling RelationsABSTRACT
Sedimentation (VSG) rate was studied following the microhematocrit technique in 40 healthy and in 52 infected preterm infants complaining of gastroenteritis, bronchopneumonia, meningitis and septicemia. In healthy infants, VSG was measured at 3, 6, 9, 15, 20, 25 and 30 days of age and in infected cases, it was measured in the course of disease or during recovery. Increment of VSG was shown in healthy cases from 1.29 mm/1 hour at the age of 3 days up to 9.39 mm/1 hour at one month of age. In infected newborns, average VSG was higher than in healthy infants in every one of the days measured. In 8 of the infants with septicemia, VSG showed a marked rise followed by drop as the patients improved. At the end, comments are made on the usefulness of the method as and aid in the diagnosis of infection in preterm newborns.
