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Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina.

Quiroga, María Paula; Andres, Patricia; Petroni, Alejandro; Soler Bistué, Alfonso J C; Guerriero, Leonor; Vargas, Liliana Jordá; Zorreguieta, Angeles; Tokumoto, Marta; Quiroga, Cecilia; Tolmasky, Marcelo E; Galas, Marcelo; Centrón, Daniela.

Antimicrob Agents Chemother ; 51(12): 4466-70, 2007 Dec.

Article in English | MEDLINE | ID: mdl-17938184

ABSTRACT

Transferable quinolone resistance has not previously been reported in Argentina. Here we describe three complex class 1 integrons harboring the novel allele qnrB10 in a unique region downstream of orf513, one of them also containing aac(6')-Ib-cr within the variable region of integrons. The three arrays differed from bla(CTX-M-2)-bearing integrons, which are broadly distributed in Argentina.

Subject(s)

DNA Transposable Elements/genetics , Drug Resistance, Bacterial/genetics , Enterobacteriaceae/genetics , Integrons/genetics , Alleles , Amino Acid Sequence , Argentina , Bacterial Proteins/genetics , Base Sequence , Cross Infection/microbiology , Enterobacteriaceae/drug effects , Enterobacteriaceae/enzymology , Enterobacteriaceae Infections/microbiology , Humans , Microbial Sensitivity Tests , Molecular Sequence Data , Polymerase Chain Reaction , Sequence Analysis, DNA , Sequence Homology, Nucleic Acid , beta-Lactamases/genetics , beta-Lactamases/metabolism

Class 2 integron with a novel cassette array in a Burkholderia cenocepacia isolate.

Ramírez, María Soledad; Vargas, Liliana Jordá; Cagnoni, Viviana; Tokumoto, Marta; Centrón, Daniela.

Antimicrob Agents Chemother ; 49(10): 4418-20, 2005 Oct.

Article in English | MEDLINE | ID: mdl-16189138

Subject(s)

Burkholderia cepacia complex/genetics , DNA Transposable Elements/genetics , Integrons/genetics , Adolescent , Burkholderia cepacia complex/isolation & purification , Burkholderia cepacia complex/pathogenicity , Cystic Fibrosis/complications , DNA, Bacterial/analysis , Genes, Bacterial , Genome, Bacterial , Humans , Integrases/classification , Integrases/genetics , Polymerase Chain Reaction , Polymorphism, Restriction Fragment Length , Sequence Analysis, DNA , Sputum/microbiology

ABSTRACT

Subject(s)

Subject(s)

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