1.
Chembiochem
; 13(15): 2209-11, 2012 Oct 15.
Article
in English
| MEDLINE
| ID: mdl-22961651
ABSTRACT
From A to B: Through detailed biochemical investigations, we discovered that VldW, an α-ketoglutarate/Fe(II)-dependent dioxygenase, regioselectively hydroxylates validamycin A to validamycin B. The results provide insights into the biosynthesis of hydroxylated validamycins and could be used to control the metabolic outcomes of the validamycin pathway.