ABSTRACT
Between August 1991 and 1992 consecutive pterygium cases and eight normal conjunctival tissues were examined for the presence of polyclonal Human Papilloma Virus (HPV) antigen by the avidin-biotin-complex technique and 16 of the pterygium cases and 25 pc of the control conjunctivas revealed HPV positivity. In six of the HPV positive pterygium tissues, there were also an epithelial proliferation. In conclusion, HPV infection was not endemic, but sporadic in Cukurova region, and it may be contributed to development of pterygium. In addition, because it is seen together with six cases of epithelial hyperplasia, it seems to play an important role in the development of neoplasia and such patients need to be followed up for possible malignant transformation.
Subject(s)
Papillomaviridae , Papillomavirus Infections/complications , Population Surveillance , Pterygium/virology , Tumor Virus Infections/complications , Adult , Case-Control Studies , Female , Humans , Male , Papillomavirus Infections/epidemiology , Papillomavirus Infections/pathology , Papillomavirus Infections/transmission , Pterygium/epidemiology , Tumor Virus Infections/epidemiology , Tumor Virus Infections/pathology , Tumor Virus Infections/transmission , Turkey/epidemiologyABSTRACT
Choroidal malign melanoma showing rapid progression in a boy 17 years old is presented. The patient was under therapy with methoxy psoralen + Ultraviolet A (PUVA)* for psoriasis vulgaris. He had undergone complete ophthalmologic examinations with three-month intervals from the beginning of this therapy. The tumor was detected in the seventh month, rapidly enlarging within the next twenty days, and eventually leading to enucleation. PUVA is known to be a risk factor for cutaneous malign melanoma. However, there is no reported incidence of choroidal malign melanoma in PUVA treated patients. To our knowledge, this is the only case showing the possible role of PUVA therapy as a predisposing factor in the development of uveal malign melanoma.
Subject(s)
Choroid Neoplasms/etiology , Melanoma/etiology , PUVA Therapy/adverse effects , Adolescent , Humans , Male , Methoxsalen , Psoriasis/drug therapyABSTRACT
Glucose 6-phosphate dehydrogenase (G6PD) activity was measured in both red blood cells and lenses of persons with cataracts living in Cukurova, the southern part of Turkey, where G6PD deficiency is well documented. The incidence of red blood cell G6PD deficiency among the patients with cataract (33.3%) was significantly higher than that in individuals with clear lenses (8.2%). The incidence of lens G6PD deficiency in a total of 52 patients with cataract was 52%. Of the lens G6PD-deficient cases, 46.2 and 28.6% of female and male patients, respectively, also showed red blood cell G6PD deficiency.
Subject(s)
Cataract/enzymology , Erythrocytes/enzymology , Glucosephosphate Dehydrogenase Deficiency/epidemiology , Lens, Crystalline/enzymology , Adult , Cataract Extraction , Cohort Studies , Female , Humans , Male , Middle Aged , TurkeyABSTRACT
A possible correlation between development of cataract and glucose 6-phosphate dehydrogenase (G6PD) deficiency in red blood cells and lenses was investigated. The distribution of cataract types in both G6PD-positive and G6PD-deficient patients, the incidence of G6PD deficiency in cortical cataract groups and the distribution of G6PD-deficient cases according to age were determined. The results showed that quite a high percentage of cortical cataractous patients had G6PD deficiency in both red blood cells and lenses.
Subject(s)
Cataract/enzymology , Erythrocytes/enzymology , Glucosephosphate Dehydrogenase Deficiency/epidemiology , Lens, Crystalline/enzymology , Adult , Cataract/classification , Cohort Studies , Female , Humans , Male , Middle Aged , Risk Factors , Sex Factors , TurkeyABSTRACT
This paper describes, to our knowledge, the first reported granuloma pyogenicum originating from the caruncle, and reviews the clinical and pathological findings associated with the disease.
