[Use of difenin in the treatment of constitutionally tall girls]. / Primenenie difenina v lechenii konstitutsional'noi vysokoroslosti u devochek.

Thirteen constitutionally tall girls marked by certain retardation of sexual development, confirmed by clinical, instrumental and laboratory studies were examined. The girls' age ranged within 11 to 15 years. The examinations were performed before and during phenytoin treatment. The data obtained indicate that during phenytoin treatment, increment of the body length decreased to 1-3 cm over one year; skeletal maturation was found to be accelerated by 2-5 years. In 8 patients, menstruations occurred by themselves and in 5, the menstrual cycle returned to normal. The rise of the content of follicle-stimulating and somatotropic hormones as well as of estradiol together with a tendency towards cortisol content lowering were recorded. Based on the studies performed it may be ascertained that the use of phenytoin inhibits the growth rate, accelerates the closing of the zones of bone growth, promotes normalization of menstrual function, and expedites menarche.

[Function of the reproductive system in pre- and pubescent girls with diffuse toxic goiter and hypothyroidism]. / Sostoianie reproduktivnoi sistemy u devochek pre- i pubertatnogo vozrasta s diffuznym toksicheskim zobom i gipotireozom.

Altogether 70 girls of pubertal age were examined: 50 with diffuse toxic goiter and 20 with hypothyrosis. A clinical picture of "hypoestrogenism" and menstrual disturbance confirmed by the results of clinical and gynecological examination and ultrasonic investigation was noted in the patients. A significant rise of the level of gonadotropic hormones correlating with the severity of disease, and a rise of the level of testosterone-estradiol binding protein were revealed. The results of the investigation suggest that changes in the reproductive system resulting from thyroid dysfunction age determined by disturbance of different links of hormonal regulation of the hypothalamo-hypophyseal-gonadal system.