[Antineoplastic effect of glutapyrone in continual gamma-irradiation of rats]. / Izuchenie antikantserogennogo deistviia glutapirona pri khronicheskom gamma-obluchenii krys.

In experiments on rats (290 animals) exposed to chronic gamma-radiation with the total dose of 10.0 Gy it was detected that prescription of synthetic pharmaceutical of the dihydropyridine class--glutapyrone--together with drinking water during 6 months reduced the rate of malignant neoplasms from 26.5% in the control group to 13% in the treated animals. In radiation-exposed rats that received glutapyrone there was a narrowing of spectrum of the emerged neoplasms (connectively-tissual tumors only) as compared to the animals of the radiated control group, where blastomas of epithelium and lymphoid origin were also revealed. Low toxicity of glutapyrone and its anticarcinogenic action show the potential for this preparation to be used in practice.

[Antineoplastic activity of 5-fluorouracil upon transdermal adminstration using "Coletex" napkins]. / Protivoopukholevaia aktivnost' 5-ftoruratsila pri ego transdermal'nom vvedenii s pomoshch'iu salfetok "Koleteks".

The paper presents data on the effect of 5-fluorouracil (5-FU)-impregnated Coletex napkins on rats and mice with transplantable subcutaneous tumors of different histological patterns: Pliss lymphosarcoma, Walker carcinosarcoma and Ehrlich carcinoma. Since the napkins showed antitumor activity it is suggested that they might find application in treating a number of oncological pathologies, particularly, skin lesions and ulcerated and necrotized tumors.

[The radioprotective effect of riboxine (inosine)]. / Radiozashchitnoe deistvie riboksina (inozina).

In experiments with mice subjected to whole-body X-irradiation a radioprotective effect of riboxine (inosine) was demonstrated. The observed effect may be attributed to the ability of the preparation to interfere with the cyclic nucleotide metabolism.

[Combined effect of metronidazole, interferon synthesis inducers and DNA repair inhibitors]. / Sovmestnoe deistvie metronidazola, induktorov sinteza interferona i ingibitorov reparatsii DNK.

In experiments on mice with solid sarcoma 37, a study was made of modification of the radiosensitizing effect of metronidazole. The increase in the leucotic interferon titre, induced by the interferon synthesis inductors, did not influence the radiosensitizing efficiency of metronidazole: after the administration of the repair inhibitor, 8-bromocaffeine, the coefficient of suppression of tumor growth was higher and the number of mice with the regressed tumors greater as compared to animals affected by metronidazole and radiation.

[Study of the toxicity and leukocyte-stimulating activity of purine derivatives]. / Issledovanie toksichnosti i leikostimuliruiushchei aktivnosti nekotorye proizvodnykh purinov.

Among newly synthesized purine compounds there are drugs that are capable to increase the leukocyte count in the peripheral blood of irradiated animals. The derivatives of xanthine and adenine under study were marked by low toxicity.

[Effect of 8-bromoadenine on DNA repair]. / Vliianie 8-bromadenina na reparatsiiu DNK.

Effects of 8-bromoadenine have been investigated on the prereplicative and post-replicative processes of DNA repair in gamma-irradiated monolayer HeLa-M cells, a method of ultracentrifugation in alkaline sucrose gradients being used. A 30-90 minutes treatment of cells with 8-bromoadenine before irradiation (1, 5, 20 krad) distinctly inhibits the DNA single-strand break repair. The molecular weight of DNA, synthesized in gamma-irradiated cells in the presence of 8-bromoadenine, is less than that synthesized without 8-bromoadenine.