Factors affecting the estimated probabilistic acute dietary exposure to captan from apple consumption.

The effect of the number of pesticide residue values below the LOQ/LOD of analytical methods, the variability of residues in individual fruits, mass of fruit units and the number of bootstrap iterations was studied on the probabilistically estimated acute exposure of consumers. The 4720 daily apple consumption data and the results of 1239 apple sample analyses for captan residues, performed within the Hungarian monitoring programme between 2005 and 2011, were used in this study as model matrix. Up to about 95th percentile exposure (µg/(kg bw·day)), simply multiplying each residue in composite samples with each consumption value gave similar estimates to those obtained with the complex procedure taking also into account the mass of and residues in individual fruits. However, the exposure above the 95th percentile calculated with the complex procedure gradually increased with increasing percentile level compared to the simple procedure. Including the high number of non-detects reduced the estimated exposure, which was the highest when only the residues measured in treated fruits were taken into account. The number of bootstrap iterations between 100 and 10,000 did not significantly affect the calculated exposure. The 99.99th percentile exposure amounted to 17.9% of the acute reference dose of 300 µg/(kg bw·day) for women of childbearing age.

[Medium-term results of the Mayo™ short-stem hip prosthesis after avascular necrosis of the femoral head]. / Mittelfristige Ergebnisse der Mayo™-Kurzschaftprothese bei Hüftkopfnekrose.

AIM: Short-stemmed prostheses are increasingly regarded as implants of first choice in coxarthrosis, especially in young patients. Despite promising short-term results, long-term follow-up studies are still lacking. Short-stemmed femoral implants are characterised by a metaphyseal osseointegration and strain distribution. Therefore a reduced stress shielding of the proximal femur is hypothesized and in some studies already proven. There is histological evidence that osteonecrosis (ON) of the femoral head may involve not only the intracapital region but also the femoral neck and metaphyseal area. This could lead to a higher rate of aseptic loosening of short-stemmed implants. The aim of this retrospective study was to analyze the midterm results of the Mayo™ short-stem prosthesis after ON with particular attention on osseointegration. METHOD: From 2002-2004, in 21 patients (2 females, 19 males; mean age 45 years; mean BMI = 27) with secondary coxarthrosis after ON implantation of 26 Mayo™ Conservative Hips was performed. Postoperatively, all patients were mobilised with full weight-bearing. Using the specially developed Wristing® software, longitudinal stem migration and varus-valgus femoral stem alignment were examined digitally in anteroposterior X-rays taken immediately after surgery and in standing AP radiographs after 8.2 months and on average after 7.9 years (16 patients). The incidence of periprosthetic radiolucent lines was captured in the anteroposterior X-rays and assigned to the Gruen zones and a DEXA scan was performed. The X-rays of a matched control group with implantation of a Mayo™ short-stem prosthesis in primary coxarthrosis were analyzed by the same method. In all patients the Harris hip score (HHS) was obtained pre- and postoperatively. RESULTS: There was no significant migration or valgus tilt of the Mayo™ prosthesis in the study and control groups during postoperative follow-up (paired t-test, p = 0.13 and 0.69, respectively). In six of 26 Mayo™-Stems 12 radiolucent lines (RL) of the Mayo™ prosthesis were observed. The control group showed at ten of 30 Mayo™ stems 17 radiolucent lines. The difference between the groups was not statistically different (chi-square test for the total number of RL: χ² = 0.001, p = 1.0 and χ² = 0.06, p = 0.79 for the number of Mayo™ stems with RL). The DEXA scan showed a slightly higher bone mineral density (BMD) in Gruen zones 3 and 5 compared with a control group: study group. In the study group the postoperative HHS was 93.5 (SD 5.6) compared to 94.2 (SD 6.9) in the control group (t-test, p = 0.63). CONCLUSION: In the mid-term course no increased migration or tilt could be proven for Mayo™ short-stem THA in patients with osteonecrosis of the femoral head. Due to the absence of differences in the occurrence of radiolucent lines and the same results in the DEXA scan an unimpaired osseointegration of the Mayo™ stem is assumed. Therefore it is concluded that the Mayo™ Conservative Hip can be regarded as an alternative for operative treatment of ON of the femoral head.

[Results of single stage vs. two-stage total knee arthroplasty]. / Ergebnisse einzeitiger vs. zweizeitiger bilateraler Knietotalendoprothetik.

BACKGROUND: The total knee arthroplasty (TKA) is a successful procedure. In cases of bilateral knee osteoarthritis, advantages of single stage TKA vs. two-stage TKA as well as the gap between the procedures in case of two-stage TKA are discussed controversially. The aim of the present study is to compare the clinical and radiographic results of single stage bilateral TKA and two-stage bilateral TKA. In cases of two-stage TKA the dependency on the gap between surgeries was determined. MATERIAL AND METHODS: In this retrospective study 43 patients with single stage TKA and 35 patients after two-stage TKA with a maximum of 12 months between surgeries were included. Follow-up was in mean 31 ± 15 months. For clinical and radiological evaluation the Knee Society score (KSS) and Stolzalpen knee score were used. Quality of life was measured by the SF-36 score. The pain was determined using a visual analogue scale (VAS). Radiological evaluation was done by use of Knee Society roentgenographic evaluation and scoring system. RESULTS: The overall hospital stay for patients with two-stage TKA (26 ± 5 days) was twice as long as for patients with single stage TKA (14 ± 4 days). Patients with single stage bilateral TKA had a significantly higher KSS level (186 ± 19 points) than patients after two-stage bilateral TKA (179 ± 22 points). Within the two-stage group the best range of motion was achieved by patients with a gap of 4 to 6 months between surgeries and a decreased point value was measured in patients with a gap of 10 to 12 months between TKAs. Using the VAS patients with simultaneous bilateral TKA had significantly increased pain levels during passive motion. Within the two-stage group there were no differences in VAS. The results of Stolzalpen knee score were comparable in both groups. The analysis of radiological measurements showed a significantly higher number of radiolucent lines (1 mm) in patients with single stage TKA without any clinical relevance or progress in follow-up. Patients with single stage bilateral TKA had a higher complication rate than patients with a two-stage procedure. In the single stage group 6 patients had to be revised because of fracture, dislocation, peroneal nerve palsy, patella lateralisation or loosening. In the two-stage group only one patient had to be revised due to a quadriceps tendon rupture caused by a fall at day one after surgery. CONCLUSION: Analysis of clinical and radiological results shows only marginal differences between the two groups. In two-stage procedures functional results were best when the second surgery was done 4 to 6 months after the first procedure. Single stage TKA had a significantly higher complication rate. However, patient and surgeon should make the decision for single or two-stage bilateral TKA individually.

[One-stage aseptic revision of loosened metatarsophalangeal prosthesis]. / Einzeitiger aseptischer Wechsel gelockerter Grosszehengrundgelenkendoprothesen.

The high loosening rate of the Moje prosthesis in the treatment of hallux rigidus caused disappointing medium term results. Arthrodesis using an iliac crest bone graft is the standard salvage procedure. We present short-term results after one-stage revision of the metatarsophalangeal joint using the TOEFIT-PLUS™ prosthesis for implant revision. Clinical and radiological examinations were performed on three metatarsophalangeal joints after explantation of the Moje prosthesis and one-stage revision using the TOEFIT-PLUS™ prosthesis for implant revision. The AOFAS score and VAS were checked preoperatively and 6 and 12 months after surgery.Good to very good short-term results after one-stage revision of the metatarsophalangeal joint using the TOEFIT-PLUS™ prosthesis for implant revision could be demonstrated in this study. One-stage revision of the arthroplasty of the metatarsophalangeal joint can increase the range of motion and avoid arthrodesis entailing iliac crest bone graft morbidity.

[Dynamic gait analysis of blocked distal tibiofibular joint following syndesmotic complex lesions]. / Dynamische Ganganalyse bei blockiertem distalem Tibiofibulargelenk nach Syndesmosenkomplexverletzungen.

AIM: Dynamic gait analysis of blocked distal tibiofibular joint (TFJ) has not performed yet. This prospective study investigated patients treated for ankle fractures with combined syndesmotic complex lesions after surgery including tibiofibular positioning screw using CT data detecting fibular maltorsion and dynamic gait analysis. METHOD: Prepublished data of 61 patients after surgical block of TFJ were analysed for torsional deformity of the distal fibula with an especially developed novel CT method. 10 of these patients were selected for dynamic pedography (emed-SF4, Novel GmbH, Munich). The measurements were accomplished one and six weeks (with blocked TFJ) and four months (with deblocked TFJ) postoperatively. RESULTS: The gait pattern of 10 pedographically investigated patients showed increased loads of the hindfoot as well as a load shift to the lateral midfoot. Four months postoperative significant differences of the plantar pressure pattern concerning the parameters force, pressure, impulse and contact time were not observed. The analysis of the foot progression angle (fpa) of the non operated feet demonstrated external rotation of 9,5 degrees in average. In comparison to the healthy side with tibiofibular positioning screw the operated feet were significantly internal rotated during the first two measurements. Patients with fibular torsional differences > 15 degrees showed not only with tibiofibular positioning screw but also after its removal a persistent difference of fpa in average of 5,6 degrees without external rotating retraction. CONCLUSIONS: The temporary blockage of TFJ results into an altered pattern of dynamic plantar pressure distribution. A constant foot progression angle in relative internal rotation is registered. After removal of the positioning screw the recovered ligamentous structures allow retraction to the anatomic position. But, concerning fibular torsional differences > 15 degrees osseous fixation leads to alterated fpa presented as diminished external rotation of the foot of the formerly fractured ankle with consecutive dysfunction of the physiologic kinematic of movement and eventual provocation of posttraumatic arthritis. AIM: Dynamic gait analysis of a blocked distal tibiofibular joint (TFJ) has not been performed yet. This prospective study investigated patients treated for ankle fractures with combined syndesmotic complex lesions after surgery including a tibiofibular positioning screw using CT data for detecting fibular maltorsion and dynamic gait analysis. METHOD: Prepublished data of 61 patients after surgical block of TFJ were analysed for torsional deformity of the distal fibula with an especially developed novel CT method. Ten of these patients were selected for dynamic pedography (emed-SF4, Novel GmbH, Munich). The measurements were accomplished one and six weeks (with blocked TFJ) and four months (with deblocked TFJ) postoperatively. RESULTS: The gait patterns of 10 pedographically investigated patients showed increased loads of the hindfoot as well as a load shift to the lateral midfoot. Four months postoperative significant differences of the plantar pressure pattern concerning the parameters force, pressure, impulse and contact time were not observed. The analysis of the foot progression angle (fpa) of the non-operated feet demonstrated external rotation of 9,5 degrees in average. In comparison to the healthy side the operated feet with tibiofibular positioning screw were significantly internally rotated during the first two measurements. Patients with fibular torsional differences > 15 degrees showed not only with the tibiofibular positioning screw but also after its removal a persistent difference of fpa in average of 5.6 degrees without external rotating retraction. CONCLUSIONS: The temporary blockage of the TFJ results into an altered pattern of dynamic plantar pressure distribution. A constant foot progression angle in relative internal rotation is registered. After removal of the positioning screw the recovered ligamentous structures allow retraction to the anatomic position. But, concerning fibular torsional differences > 15 degrees osseous fixation leads to alterated fpa presented as diminished external rotation of the foot of the formerly fractured ankle with consecutive dysfunction of the physiologic kinematic of movement and eventual provocation of posttraumatic arthritis.

[Complex proximal humerus fractures--management with a humeral head prosthesis? Clinical and radiological results of a prospective study]. / Die Humeruskopfmehrfragmentfraktur--Versorgung mit einer Humeruskopfprothese? Klinische und radiologische Ergebnisse einer prospektiven Studie.

BACKGROUND: Proximal humerus fractures are one of the most common fractures in elderly patients. In the treatment of complex proximal humerus fractures, primary hemiarthroplasty is still discussed controversially. The present study was undertaken to evaluate the results of primary hemiarthroplasty in the treatment of proximal humerus fractures with a modular prosthesis (EPOCA, Fa. Argomedical, Gifhorn, Germany). MATERIAL AND METHODS: A prospective study of 24 patients with complex humerus fracture (NEER: IV/4, V/4, VI/4, and head split fracture) was performed from August 2000 to December 2002. Mean age was 75.6 years (range: 52-92); 18 patients were seen for follow-up after 0.5 and 1 year, respectively. The Constant-Murley score (max. 100 points) and the UCLA Rating System (max. 35 points) were calculated for functional assessment of the operated shoulder. RESULTS: Fifteen patients (83%) were pain free 1 year after the operation. The Constant-Murley score improved from 52 (+/-17) to 56 (+/-18) at the second follow-up after 1 year. On the contralateral side a score of 86 (+/-10) was assessed (p<0.05 vs operated side). Correspondingly, shoulder function according to the UCLA Rating System improved [25 (+/-4); 27 (+/-5)]. CONCLUSIONS: Osteoporotic bone of older patients often may not permit stable internal fixation of complex proximal humerus fractures. In these situations primary hemiarthroplasty is the treatment of choice.