Subject(s)
Detergents/pharmacology , Erythrocyte Membrane/metabolism , Lipids/blood , Membrane Proteins/blood , Sodium Dodecyl Sulfate/pharmacology , Circular Dichroism , Erythrocyte Membrane/drug effects , Humans , In Vitro Techniques , Membrane Proteins/drug effects , Protein Conformation/drug effectsABSTRACT
A study was made of the content of amino acids in blood plasma of dogs and rats and daily excretion thereof from rat body in urine after local X-irradiation of abdomen with a dose of 13.5 Gy. As the gastrointestinal syndrome developed the content and excretion of taurine increased, glucogenic amino acid content of plasma decreased, and the ratio of phenylalanine to tyrosine and branched-chain amino acids to aromatic amino acids changed. The ratio of arginine to ornithine and urea to ammonia sharply dropped in animals, which died later on, indicating that the urea-producing function of liver was impaired and hyperammonemia developed.
Subject(s)
Abdomen/radiation effects , Amino Acids/radiation effects , Amino Acids/metabolism , Amino Acids, Branched-Chain/metabolism , Amino Acids, Branched-Chain/radiation effects , Amino Acids, Sulfur/metabolism , Amino Acids, Sulfur/radiation effects , Animals , Dogs , Male , Nitrogen/metabolism , Radiation Injuries, Experimental/metabolism , Radiation Injuries, Experimental/mortality , Rats , Rats, Inbred Strains , Time FactorsSubject(s)
Erythrocyte Membrane/drug effects , Hemoglobins/metabolism , Sodium Chloride/pharmacology , Dose-Response Relationship, Drug , Erythrocyte Membrane/metabolism , Erythrocyte Membrane/ultrastructure , Hemolysis/drug effects , Humans , Hydrogen-Ion Concentration , Hypotonic Solutions , Microscopy, Electron, Scanning , Protein Binding/drug effectsSubject(s)
Amino Acids/blood , Parenteral Nutrition , Stomach Neoplasms/therapy , Adult , Aged , Humans , Middle AgedSubject(s)
Amino Acids/blood , Hepatitis/blood , Liver Cirrhosis/blood , Parenteral Nutrition , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Amino Acids/administration & dosage , Parenteral Nutrition , Aged , Animals , Body Weight/drug effects , Clinical Trials as Topic , Dogs , Drug Evaluation, Preclinical , Female , Humans , Male , Middle Aged , Nitrogen/metabolism , Postoperative Care/methods , Protein Deficiency/therapy , Rats , Time Factors , USSRSubject(s)
Erythrocyte Membrane , Erythrocytes , Hemolysis , Hemolysis/drug effects , Humans , Methods , Sodium Chloride/pharmacologyABSTRACT
Viscosity, dispersion of optical rotation and circular dichroism of collagen solutions was determined. Collagen solutions were obtained after treating collagen with enzymes--protorizine or prototerrizine, or with the mixture of 2,5 M NaOH--1 M Na2SO4 and acid-soluble collagen from calf skin. Molecules of "forcedly" solved collagen have an asymmetric shape with a conformation of a three-helical helix. After being heated the latter undergoes the transformation helix-coil similar to tropocollagen molecules.