ABSTRACT
In 197 cases with various bronchopulmonary affections, iron was dosed in serum, according to Weippel's method, and copper, according to Cantarov's method. Cu/Fe serous ratio was found in the normal patients between 0.7 and 1.7 higher than the control sample were reached (1.2); in OCBP the ratio was twice versus the control sample (2.62 versus 1.2). In the disease diagnosis and prognosis, the determination of the Cu/Fe serous ratio is suggested in those suspected of bronchopulmonary cancer. The increase of the ratio shows the aggravation by metastases, and the improvement after operations indicates the lack of metastases. The advantages of the test are: sensitivity, specificity, predictability, economy.
Subject(s)
Bronchial Neoplasms/blood , Copper/blood , Iron/blood , Lung Neoplasms/blood , Bronchial Neoplasms/diagnosis , Bronchial Neoplasms/etiology , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/etiology , Methods , Prognosis , Sensitivity and SpecificitySubject(s)
Antibiotics, Antineoplastic/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biological Products , Carcinoma, Small Cell/drug therapy , Lung Neoplasms/drug therapy , Adult , Aged , Antibiotics, Antineoplastic/administration & dosage , Antibiotics, Antineoplastic/adverse effects , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Drug Evaluation , Female , Humans , Male , Middle AgedABSTRACT
The authors have studied the evolution of serum parameters of iron metabolism in patients with tuberculosis during the standard chemotherapy. The results are discussed, in the perspective of a model of natural resistance depending on iron. No strict correlation was found between the bacteriostatic capacity of the serum and the process of saturation with iron of transferrin, probably due to participation in the bacteriostatic effect of other factors beside transferrin. The results have demonstrated that the imbalance between the serum values of copper (that are increased), and those of iron (that are low) tends to become normal during the recovery, as evaluated by a negativation of the sputum cultures. These results suggest that the use of a ratio between copper and iron in the blood serum as a method for assessing the recovery of the balance in the tuberculous organism during therapy is justified.
