[The pharmacological properties of the triterpenoids from birch bark]. / Farmakologicheskie svoistva triterpenoidov kory berezy.

The birch bark was used to prepare the summary triterpenic drug betulenol and its diacetate. Rat experiments with models of abnormalities revealed their hypolipidemic, cholagogic, antilithogenic and hepatoprotective activities which were higher than those found in the respective official drugs.

[The effect of tetracycline and silibore on lipid peroxidation in the liver od rats of various age]. / Vliianie tetratsiklina i silibora na perekisnoe okislenie lipidov pecheni krys raznogo vozrasta.

As shown by accumulation of malonic dialdehyde and chemiluminescence rate monitoring tetracycline activated both NADPH- and ascorbate-dependent lipid peroxidation in liver tissue of 1, 3, 12 and 24 months old rats. The most distinct induction of lipid peroxidation was observed in old animals, which appears to occur due to a decrease in efficiency of NADPH-GSH-dependent enzymatic antioxidant system. Silibore prevented the stimulating effect of tetracycline on enzymatic and nonenzymatic lipid peroxidation, being apparently involved in hepatoprotective effect.

[Changes in lysozyme activity in hyperlipidemia and atherosclerosis in animals]. / Izmenenie aktivnosti lizotsima pri giperlipidemii i ateroskleroze u zhivotnykh.

The lysocyme activity in blood serum and liver hemogenate of rats and rabbits at hyperlipidemia and atherosclerosis and its treatment with some new compounds or chemicals has been studied. A change of natural resistance of the body at hyperlipidemia and atherosclerosis characterized by the increase of serum lysocyme activity has been found. Preparations used in this work exerted mobilizing effect on the level of serum lysocyme activity but their influence on the functional state of the liver was different.

[Hypolipidemic properties of triterpenoids]. / Gipolipidemicheskie svoistva triterpenoidov.

Experiments on rabbits and white rats with experimental hyperlipidemia and atherosclerosis have shown that pentocyclic triterpenoids belonging to the alpha- and beta-amirin groups, of which saparal, glyciram and glycirenate are officinal drugs, are capable of reducing the level of cholesterol, beta-lipoproteins and triglycerides in the blood and that of cholesterol in aorta tissues. The effect of the compounds under study has been found to exceed the hypolipidemic action of the officinal antiatherosclerotic drugs, polysponine and cetamiphen, and to be noted for low toxicity. To screen hypolipidemic properties in the substances, an effective modification of experimental hyperlipidemia in rats has been offered.

[Sulfanilamide absorption and acetylation in rats with experimental hyperlipidemia and cellular regulation of the process of acetylation]. / Vsasyvanie i atsetilirovanie sul'fanilamidov pri éksperimental'noi giperlipidemii u krys i kletochnaia reguliatsiia protsessa atsetilirovaniia.

Experiments on an isolated ileum of the rat with experimental hyperlipidemia have shown the decreased acetylation rate of sulfalen, sulfamonomethoxin and sulfapyridazine. The absorption rate of the free forms of sulfanilamides was increased (significantly for sulfalen and sulfapyridazine). Isadrin (1 . 10(-8) M) and cAMP (1 . 10(-5) M) introduced into the liquid exposed to the mucosa of the rat ileum raised the acetylation rate of sulfamonomethoxin by the ileic wall while anaprilin (1 . 10(-6) M) led to the reduction of both absorption and acetylation of this sulfanilamide. Addition of cAMP to the incubation mixture of mitochondria and microsomes increased the acetylation rate of sulfamonomethoxin.