[The action of nitrobenzene and its chlorine derivatives on the indices of antioxidative homeostasis in rat tissues]. / Deistvie nitrobenzola i ego khlor-proizvodnykh na nekotorye pokazateli antiokislitel'nogo gomeostaza v tkaniakh krys.

The authors studied the rate of lipid peroxidation, antioxidative activity and content of vitamin E in the liver and spleen of rats given nitrobenzene, o-nitrochlorbenzene and p-nitrochlorbenezene. The xenobiotics increased LPO, antioxidative activity (AOA), splenic levels of vitamin E. The subchronic influence of the substances led to stabilization of LPO, changes in the activation of the body's adaptation. The AOA and vitamin E play an important role in the regulation of antioxidative homeostasis.

[Lipid peroxidation in the liver microsomes--a sensitive link in body exposure to vat dyes]. / Perekisnoe okislenie lipidov v mikrosomakh pecheni--chuvstvitel'noe zveno vozdeistviia na organizm nekotorykh kubovykh krasitelei.

Experiments on male white rats showed that the soluble forms of vat dyes such as red brown 'G' (RBG) and bright green 'G' (BGG) delivered into the stomach in a toxic dose (1 g/kg) activate lipid peroxidation (LPO) in liver microsomes. Chronically inhaled dyes hasten of slow down some LPO stages, the changes depending on the concentration, duration of exposure and chemical structure of a compound. Soluble vat dye RBG increases LPO in concentration 5 mg/m3 whereas RBG shows antioxidant action in high and low concentrations.

[Study of the reproductive function in albino rats after inhalation of 4,4'-diaminodiphenyl ether of resorcin]. / Issledovanie reproduktivnoi funktsii belykh krys pri ingaliatsionnom vozdeistvii 4,4'-diaminodifenilovogo éfira resortsina.

The article contains experimental data on the morphofunctional state of gonads in male rats after chronic inhalation of diamine P, and on the state of embryogenesis after inhalant introduction of diamine P into pregnant rats in threshold-level concentrations. Results of the study revealed that, in chronic inhalant introduction at 29.3 and 4.2 mg/m3, diamine P demonstrated gonadotoxic properties, which was proved by the higher percentage of dead spermatozoa and spermatogonium diseases. The changes in the gonads' state reflected the pathological processes caused by diamine P in the animals due to the general toxicity properties of the substance. The embryotoxic effect of diamine P in inhalations at 5 mg/m3 (close to the threshold levels of total toxicity) was not statistically relevant.

[Substantiation of group MPEL for dispersive anthraquinone dyes]. / K obosnovaniiu gruppovoi PDK dispersnykh antrakhinonovykh krasitelei.

The article presents results of the toxicological studies of 65 replaced anthraquinones: amino-, diamino-, haloido-, hydro- and oxianthraquinones. A similar polytropic toxic action was identified. MACs for anthraquinones, alpha-aminoanthraquinones and K-type dispersal dye-stuff were established at 5 mg/m3. The toxicity properties of 11 other dispersal dye-stuffs with anthraquinone and NF disperser were studied. Similarity in the toxic properties of the dispersal dye-stuffs and those of the earlier standardized anthraquinone derivatives were established. The group MACs for the pigment and NF disperser containing dispersal anthraquinone dye-stuffs at 5 mg/m3 was established and subsequently formally adopted. A possibility of chemical assessment of dye-stuff dust concentrations against NF disperser (MAC at 2 mg/m3) was taken into account.

[Gonadotoxic action of acetylsalicylic acid]. / O gonadotoksicheskom deistvii atsetilsalitsilovoi kisloty.

It has been established in experiments on white rats that administration of acetylsalicylic acid (ASA) in a dose of 1/10 LD50 for 1 1/2 months is accompanied by a decrease in the functional activity of spermatozoids. Repeated inhalation of ASA dust at a concentration of 25 mg/m3 for 4 months produces morphological changes in the spermatogenic epithelium and abnormal antenatal development of the progeny of male animals under test.