[The mechanisms of the temperature sensitivity of the hypothalamic neurons]. / Mekhanizmy temperaturnoi chuvstvitel'nosti neironov gipotalamusa.

Studies of the 1960-80-s in intact animals and brain slices showed the existence of brain temperature-sensitive neurons in the vertebrate hypothalamus. Increased firing rate of these units activates the thermoregulatory processes. Applications of synaptic blockade in slices, and of intracellular recordings and clamp technique in the last 3-4 years allowed to find that many hypothalamic thermosensitive neurons possess an intrinsic mechanism of temperature sensitivity central to. This mechanism is a change in ionic permeability of neuronal membrane. The review summarizes the results of these studies and considers possible causes of thermo-induced changes in ionic conductivity of hypothalamic thermosensitive neuron membrane.

[Temperature dependence of neuronal activity in hypothalamic and hippocampal slices of the guinea-pig]. / Zavisimost' aktivnosti neironov ot temperatury v srezakh gipotalamusa i gippokampa morskoi svinki.

Unit activity in slices of the hippocampus and medial preoptic area of the hypothalamus of guinea-pigs was extracellularly recorded under conditions of temperature changes. Seven out of nineteen hypothalamic neurons showed changes in the firing rate at threshold temperatures of 36-38 degrees C. In the suprathreshold range the activity of these neurons depended on the temperature level. It is suggested that such neurons may form a sensory part of the system controlling brain temperature within a narrow (1-2 degrees C) range. The pyramidal layer cells of the control structure (hippocampus) were insensitive to the temperature level within 32-40 degrees C.