Systematic analysis for the relationship between obesity and tuberculosis.

OBJECTIVES: Underweight or low body mass index (BMI) is an established risk factor for active tuberculosis. Recent evidence, however, suggests that overweight is associated with lower incidence of tuberculosis. The objective of this systematic review and meta-analysis is to understand the relationship between obesity and tuberculosis and document the extent of association between the two conditions over the range of BMI from underweight to obesity. METHODS: A comprehensive literature search was conducted to identify studies reporting prevalence of the different BMIs in patients with tuberculosis and controls. Thirty studies of adult humans reporting the incidence of tuberculosis at different weight categories were selected for inclusion for meta-analysis in the present study. RESULTS: In tuberculosis, the prevalence of underweight was 3-fold higher than that in controls (P = 0.001) whereas the proportion of overweight and obesity was 2-fold lower (P = 0.001). One unit increase in BMI was associated with 2% reduction in tuberculosis incidence (P < 0.001). Adjusted odds ratio of tuberculosis was 4.96 (95% confidence interval: 4.87-5.05) in underweight and 0.26 in obesity. CONCLUSION: This study further establishes low body weight as a risk factor for tuberculosis whilst overweight and obesity are associated with lower disease risk. Body weight can be considered as a prognostic indictor in the clinical course of tuberculosis.

Development and characterization of polyethylene glycol-carbon nanotube hydrogel composite.

Carbon nanotube (CNT)-hydrogel composites are attractive for a variety of neural tissue engineering and drug delivery applications as well as biosensor coatings, transducers and leads. Both materials contribute unique and beneficial properties to the composites. Hydrogels are an excellent mimic of the extracellular matrix due to their hydrophilicity, viscoelasticity and biocompatibility. CNTs, on the other hand, can impart electroconductivity to otherwise insulating materials, improve mechanical stability and guide neuronal cell behavior as well as elicit axon regeneration. Not surprisingly, there has been a surge in the development of various CNT-hydrogel composites including both natural and synthetic polymers. Here, we describe a CNT-polyethylene glycol (PEG) hydrogel composite where the CNTs are entrapped in the hydrogel phase during gelation. The hydrogel crosslinking reaction is based on Michael-type addition which is ideal for in situ cell and protein encapsulation. To adequately disperse the highly hydrophobic CNTs in the aqueous polymer solution, we used sonication and surfactants, where bovine serum albumin was found to be an effective and non-cytotoxic dispersant. We demonstrate that the inclusion of the CNTs impeded the hydrogel crosslinking leading to longer gelation times, higher swelling and porosity, and lower storage modulus above a threshold CNT concentration. As anticipated, composite hydrogel resistivity decreased with the incorporation of CNTs and was dependent on both CNT loading and dispersion. Importantly, unlike the PEG hydrogel alone, the PEG-CNT hydrogel composite was capable of supporting high neural cell viability where the CNTs provided sites for cell attachment.

Bulgarian Turkish emigration and return.

PIP: The main factors which determined the 1989 migration of Turks in Bulgaria back to Turkey are discussed. Background history is provided. After World War I, Turks in bulgaria comprised 10% of the total population. Bulgarian policy had been, up to the 1980s to send Rumelian Turks back, but the policy after 1980 was one of a national revival process to integrate Turks into the developed socialist society. Muslim traditions, customs, and Turkish language were interfered with. International disfavor resulted. In May 1989, the Communist Party declared, in an effort to show democratic ideals, open borders. Thus began the new emigration wave. 369,839 people fled to the Turkish border. 43% of the 9.47 ethnic Turks in bulgaria went to Turkey within 4 months. The numbers decreased in November, and soon after the communist regime ended. New laws were adopted allowing Turks to assume their original Turkish names. The huge migration was clearly political, and as such, the emigrant Turks should be determined as refugees and asylum seekers. The provocation of ethnic Turks was used by the communist regime to solve potential social conflicts. Not only did Turks flee to escape from violence or for religious, cultural, and moral reasons but also due to free market initiatives begun in Turkey in the early 1980s which improved Turkish quality of life. Food and consumer goods were cheaper and economic advantages were perceived. Emigrants were primarily peasants with lower levels of education, professional qualifications, and labor skills. 154,937 (42%) returned to bulgaria and 58% stayed in Turkey to comprise 25% of the former Turkish population. During this period, tensions between countries was high.l Bulgarians actively encouraged emigration and Turkey welcomed it. The emigrants to Turkey were seen as foreigners (muhacir or gocmen) but were received with good will and were readily accepted into menial positions. Emigrants were confronted with political, linguistic, and cultural differences. The unifying factor was the Islamic religion. For those returning to Bulgaria, the change in regime meant the government worked to solve the emigrants' housing problems and teaching Turkish in primary and secondary schools. The result of this massive migration has been a change in the demographics and social structure of Bulgaria, and the realization that forceful migration is inefficient in solving problems.^ieng