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[Possible explanations of molecular mechanisms underlying etiology and pathogenesis of periodic disease]. / Vozmozhnye podkhody k ob''iasneniiu molekuliarnykh mekhanizmov étiologii i patogeneza periodicheskoi bolezni.

Arutiunian, V M; Grigorian, E G; Karagezian, K G; Vasilian, A A; Arutiunian, M S; Ovsian, G A.

Klin Med (Mosk) ; 77(11): 57-9, 1999.

Article in Russian | MEDLINE | ID: mdl-10635639

Subject(s)

Familial Mediterranean Fever/etiology , Serum Amyloid A Protein/genetics , Cell Division , Chromosome Aberrations/etiology , Chromosome Aberrations/genetics , Chromosome Aberrations/pathology , Chromosome Disorders , Chromosomes, Human, Pair 16 , Epithelium/metabolism , Epithelium/pathology , Familial Mediterranean Fever/genetics , Familial Mediterranean Fever/pathology , Genetic Predisposition to Disease , Humans , Mutation

[Effect of GABA and piracetam on on ATPase activity in brain and liver mitochondria in experimental hypokinesis]. / Vliianie GAMK i piratsetama na ATF-aznuiu aktivnost' mitokhondrii mozga i pecheni v usloviiakh éksperimental'noi gipokinezii.

Akopian, V P; Sotskii, O P; Mailian, K R; Edigarova, L V; Shafrazian, D S; Vasilian, A A.

Vopr Med Khim ; 44(3): 262-6, 1998.

Article in Russian | MEDLINE | ID: mdl-9703626

ABSTRACT

Long-term hypokinesia is accompanied by changes in the activity of Mg(2+) and 2,4-dinitrophenol (DNP)-stimulated ATPases of rat brain and liver mitochondria. These changes are phasic and especially pronounced at periods characterised by most pronounced metabolic alterations Treatment of animals with GABA and piracetam tends to normalise the enzyme activities.

Subject(s)

Adenosine Triphosphatases/metabolism , Brain/drug effects , Hypokinesia/enzymology , Mitochondria, Liver/drug effects , Piracetam/pharmacology , gamma-Aminobutyric Acid/pharmacology , 2,4-Dinitrophenol/pharmacology , Animals , Brain/metabolism , Enzyme Activation , Magnesium/metabolism , Male , Mitochondria/drug effects , Mitochondria/metabolism , Mitochondria, Liver/metabolism , Rats

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