ABSTRACT
As many as 170 patients with giant cell tumour of the bone were examined in the Institute of Oncology department of tumours of the locomotorium. The diagnosis of giant cell tumour of the bone was made with a comprehensive approach to the patients pursued to include roentgenography, computerized tomography, biopsy involving histological study of the specimens taken.
Subject(s)
Bone Neoplasms/diagnosis , Giant Cell Tumor of Bone/diagnosis , Biopsy , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Diagnosis, Differential , Giant Cell Tumor of Bone/diagnostic imaging , Giant Cell Tumor of Bone/pathology , Humans , Radiography , Radionuclide ImagingABSTRACT
Over the period of past five years, in the department of tumours of the locomotorium of the Institute of Oncology, 170 patients with giant cell tumor of the bone who ranged from 7 to 72 years old were examined. Of these, 152 patients were cured, 14 experienced recurrences of the tumour after the treatments administered, four patients died within different time periods after the treatment conducted as a result of metastizing of the tumour into different organs and systems (lungs, liver, bony skeleton).
Subject(s)
Bone Neoplasms/diagnosis , Giant Cell Tumor of Bone/diagnosis , Adolescent , Adult , Aged , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/surgery , Child , Female , Giant Cell Tumor of Bone/secondary , Giant Cell Tumor of Bone/surgery , Humans , Liver Neoplasms/secondary , Lung Neoplasms/secondary , Male , Middle Aged , Neoplasm Recurrence, Local/epidemiology , Radiography , Retrospective Studies , Treatment OutcomeABSTRACT
Essential changes in the thymus functional condition and hypophyseal-adrenal system were revealed in patients with skin melanoma. The secretory activity of the thymus loosens, and there is a reduction of thymic hormone titer in blood. The increased levels of ACTH and hydrocortisone in blood indicate an enhanced activity of the hypophyseal-adrenal system under this pathology.
Subject(s)
Melanoma/physiopathology , Pituitary-Adrenal System/physiopathology , Skin Neoplasms/physiopathology , Thymus Gland/physiopathology , Adrenocorticotropic Hormone/blood , Adult , Female , Humans , Hydrocortisone/blood , Male , Middle Aged , Thymic Factor, Circulating/analysisABSTRACT
TI-2NOMO skin melanoma patients revealed pronounced functional disturbances of the pineal gland and pituitary-adrenal system. The decline in functional activity of the former was manifested by a decrease in urine excretion of melatonin. Enhanced levels of blood ACTH, alpha-MSH and cortisole pointed to the activation of pituitary-adrenal system which was particularly high in males. The degree of endocrine disorders was found to be in correlation with tumor stage. As far as pathogenesis of the lesion is concerned, preparations which bring function of endocrine glands to normal should be adjuvant to available treatment modalities for melanoma.
