ABSTRACT
Treatment of mice by a combination of succinic and glutamic acids prevented the metabolic disorders in the liver under conditions of normobaric hypoxia. In addition, the activity of the mitochondrial fast metabolic cluster remained intact and lipid peroxidation was limited.
Subject(s)
Energy Metabolism/drug effects , Glutamic Acid/pharmacology , Hypoxia/physiopathology , Liver/drug effects , Liver/metabolism , Succinic Acid/pharmacology , Animals , Drug Combinations , Lipid Peroxidation/drug effects , Male , Mice , Mitochondria, Liver/drug effects , Mitochondria, Liver/metabolismABSTRACT
Cerebronorm prevents de-energization of mitochondria, limitation of succinate- and NAD-dependent energy production, and oxidation-phosphorylation uncoupling and inhibits LPO processes in the brain of rats under conditions of hypoxia.
Subject(s)
Brain/metabolism , Energy Metabolism/physiology , Hypoxia/physiopathology , Lipid Peroxidation/physiology , Animals , Brain/drug effects , Energy Metabolism/drug effects , Inosine Diphosphate/pharmacology , Lipid Peroxidation/drug effects , Male , Mitochondria/drug effects , Mitochondria/metabolism , Niacinamide/pharmacology , Oxidative Phosphorylation/drug effects , Rats , Riboflavin/pharmacology , Succinic Acid/pharmacologyABSTRACT
Silymarin (70 mg/kg) and succinic acid (50 mg/kg) reduce blood glucose and cholesterol concentrations, inhibit LPO, and correct oxidative phosphorylation disturbances in liver mitochondria in experimental diabetes mellitus induced by injection of streptozotocin (65 mg/kg) in rats.
