Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Pediatr Pulmonol ; 42(12): 1181-6, 2007 Dec.
Article in English | MEDLINE | ID: mdl-17926338

ABSTRACT

UNLABELLED: Laryngeal exposure to acid and aspiration of gastric contents may lead to severe respiratory disorders. This study utilizes the canine model of Gastroesophageal reflux (GER) to identify whether lower esophageal dysfunction is associated with upper and lower airway pathology. MATERIALS AND METHODS: Five mongrel dogs underwent GER-creating surgery (partial cardiomyectomy). Laryngeal reflux finding score (RFS), lipid-laden macrophage index (LLMI) and BAL fluid cell differential were obtained before and after surgery. RESULTS: Partial cardiomyectomy in dogs significantly increased the Reflux index (RI) from 0.38 +/- 0.21% to 7.56 +/- 2.89% (P = 0.048), the duration of the longest reflux episode (DLRE) from 1.22 +/- 1.19 min to 66.2 +/- 42.03 min postoperatively (P = 0.049) and the total number of episodes in 24 hr from 2.06 +/- 1.03 to a postoperative value of 19.24 +/- 4.79. There was no statistically significant change in values for RFS, LLMI, and BAL fluid cell differential after the induction of GER. CONCLUSIONS: Acid reflux to the proximal esophagus of this animal model did not cause laryngeal exposure to acid or aspiration of gastric content. The results of this study suggest that presence of GER, secondary to lower esophageal dysfunction is not necessarily associated with upper and lower airway pathology.


Subject(s)
Gastroesophageal Reflux/metabolism , Lipids/analysis , Macrophages, Alveolar/pathology , Animals , Bronchitis/diagnosis , Bronchitis/etiology , Bronchoalveolar Lavage Fluid/chemistry , Bronchoalveolar Lavage Fluid/cytology , Bronchoscopy/methods , Disease Models, Animal , Dogs , Esophagus/metabolism , Esophagus/pathology , Gastric Acid/metabolism , Gastroesophageal Reflux/complications , Gastroesophageal Reflux/pathology , Hydrogen-Ion Concentration , Laryngitis/diagnosis , Laryngitis/etiology , Laryngitis/metabolism , Laryngoscopy , Risk Factors , Severity of Illness Index
SELECTION OF CITATIONS
SEARCH DETAIL
...