Nosocomial outbreak of extended-spectrum ß-lactamase-producing Enterobacter cloacae among cardiothoracic surgical patients: causes and consequences.

BACKGROUND: Enterobacteriaceae are recognized as leading pathogens of healthcare-associated infections. AIM: To report the investigation of a nosocomial outbreak of extended-spectrum ß-lactamase-producing Enterobacter cloacae affecting cardiothoracic surgery patients in a Belgian academic hospital. METHODS: Cases were defined based on epidemiological and microbiological investigations, including molecular typing using repetitive element-based polymerase chain reaction and multi-locus sequence typing. Case-control studies followed by field evaluations allowed the identification of a possible reservoir, and the retrospective assessment of human and financial consequences. FINDINGS: Over a three-month period, 42 patients were infected or colonized by CTX-M-15-producing E. cloacae strains that belonged to the same clonal lineage. Acquisition mainly occurred in the intensive care unit (N = 23) and in the cardiothoracic surgery ward (N = 16). All but one patient had, prior to acquisition, undergone a cardiothoracic surgical procedure, monitored by the same transoesophageal echocardiography (TOE) probe in the operating room. Despite negative microbiological culture results, the exclusion of the suspected probe resulted in rapid termination of the outbreak. Overall, the outbreak was associated with a high mortality rate among infected patients (40%) as well as significant costs (€266,550). CONCLUSION: The outbreak was indirectly shown to be associated with the contamination of a manually disinfected TOE probe used per-operatively during cardiothoracic surgery procedures, because withdrawal of the putative device led to rapid termination of the outbreak.

[Standardisation of methods for dilution of intravenous medications in hospital]. / Standardisation des méthods de dilution des medications injectables en unites de soins intensifs et unites conventionnelles.

Introduction The administration of intravenous medications in hospital is a common practice. Although it may seem almost insignificant, this practice remains no less an act which involves risks, due to many factors identified. It is therefore important to gather, clarify and communicate the updated information on the modalities of the administration of these injections in order to facilitate and secure the work of the teams of care with a view of an optimal and standardized administration of intravenous medications. Method The tables of standardization of injectable drugs have been made on several occasions in the past and distributed in the care units. The latest version of these documents was reviewed and updated in the light of the recent editions of several sources. The data concerning each individual injectable medicine have individual as well been systematically updates. The updated data have been integrated into the electronic prescription of medicines, a standardized dilution is now proposed by default to the prescriber. For some drugs, special modalities of administration have been planned to meet the specific needs of patients hospitalized in the Intensive Care Unit (ICU). Results The methods for dilution of injections in classical hospitalization have been integrated in the electronic prescribing software (238 "packages" in total. The specific dilutions used in the ICU (48 in total, have been validated but may not be used in the conventional care units. Conclusion All of the information relating to the methods of preparation and administration have been gathered and clarified in order to facilitate and secure the work of the teams of care and thus enable optimal administration of intravenous medications. The information is accessible on paper file and via the internal computer network, the PC of intensive care units and the software Computerized prescription.