ABSTRACT
Aorto femoral bypass is usually the recommended therapy for diffuse disease involving the aorta and iliac arteries. In this case report, a case involving a chronic endovascular abdominal aortic stent graft occlusion in which percutaneous angioplasty was performed via a transbrachial and transfemoral approach is presented. This case emphasized that occlusion of an endovascular abdominal aortic stent graft can also be treated, primarily, with an endovascular technique.
Subject(s)
Angioplasty/methods , Aorta, Abdominal , Arterial Occlusive Diseases/therapy , Stents/adverse effects , Aortic Aneurysm, Abdominal , Female , Humans , Middle AgedABSTRACT
Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1ß (IL-1ß), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-α, IL-1ß, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
Subject(s)
Cytokines/blood , Mitral Valve Insufficiency/blood , Nerve Growth Factors/blood , Selenium/blood , Vascular Endothelial Growth Factor A/blood , Zinc/blood , Adult , Female , Humans , Male , Middle Aged , Midkine , Rupture, Spontaneous/bloodABSTRACT
The case presented is the first patient with concurrent acute interstitial pneumonia and pulmonary embolism associated with combined treatment of peginterferon and ribavirin for hepatitis C.
Subject(s)
Hepatitis C/drug therapy , Interferon-alpha/adverse effects , Lung Diseases, Interstitial/chemically induced , Polyethylene Glycols/adverse effects , Pulmonary Embolism/chemically induced , Ribavirin/adverse effects , Acute Disease , Hepatitis C/complications , Humans , Interferon-alpha/administration & dosage , Interferon-alpha/therapeutic use , Lung Diseases, Interstitial/complications , Lung Diseases, Interstitial/diagnosis , Lung Diseases, Interstitial/drug therapy , Middle Aged , Polyethylene Glycols/administration & dosage , Polyethylene Glycols/therapeutic use , Pulmonary Embolism/complications , Pulmonary Embolism/diagnosis , Pulmonary Embolism/drug therapy , Recombinant Proteins/administration & dosage , Recombinant Proteins/adverse effects , Recombinant Proteins/therapeutic use , Ribavirin/administration & dosage , Ribavirin/therapeutic use , Treatment OutcomeABSTRACT
Background. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels. Methods. Between 2008 and 2011, 23 patients underwent successfully percutaneous ventricular septal defect closure in 4 cardiology centers. Brain natriuretic peptide levels were measured in nine patients (4 male, mean ages were 25.3 ± 14.3) who underwent percutaneous closure with Amplatzer occluders for membranous or muscular ventricular septal defects were enrolled in the study. Brain natriuretic peptide levels were measured one day before and one month after the closure. Patients were evaluated clinically and by echocardiography one month after the procedure. Results. Percutaneous closures of ventricular septal defects were successfully performed in all patients. There was not any significant adverse event in patients group during followup. Decrease in brain natriuretic peptide levels after closure were statistically significant (97.3 ± 78.6 versus 26.8 ± 15.6, P = 0.013). Conclusion. Brain Natriuretic Peptide levels are elevated in patients with ventricular septal defects as compared to controls. Percutaneous closure of Ventricular Septal Defect with Amplatzer occluders decreases the BNP levels.
Subject(s)
Cardiovascular Surgical Procedures , Heart Septal Defects, Ventricular/blood , Heart Septal Defects, Ventricular/surgery , Natriuretic Peptide, Brain/blood , Septal Occluder Device , Biomarkers/blood , Humans , Male , Middle Aged , Plastic Surgery Procedures , Treatment OutcomeABSTRACT
The incidence of dual left anterior descending coronary artery (LAD) in normal hearts has been reported to range from 0.13 to 1%. Type IV dual LAD differs from the other three types in the origination of the long LAD from the right coronary sinus. We present a case of type IV dual LAD in a patient with anterior myocardial infarction related to the short LAD.
Subject(s)
Anterior Wall Myocardial Infarction/etiology , Coronary Vessel Anomalies/complications , Angioplasty, Balloon, Coronary/instrumentation , Anterior Wall Myocardial Infarction/diagnosis , Anterior Wall Myocardial Infarction/therapy , Coronary Angiography , Coronary Vessel Anomalies/diagnosis , Electrocardiography , Humans , Male , Middle Aged , Stents , Treatment OutcomeABSTRACT
Understanding the exact pathophysiological mechanism of degenerative aortic stenosis is important in order to develop new treatment modalities and prevent progression of the disease. Recently, most of the inflammatory markers in association with aortic stenosis have been described. The authors of the paper under evaluation investigate the effects of the 5-lipoxygenase pathway on aortic valve stenosis and correlation with severity of stenosis. In this article, we suggest that the 5-lipoxygenase pathway is one of the possible factors in the development of aortic stenosis.