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5.
Science ; 176(4037): 934-6, 1972 May 26.
Article in English | MEDLINE | ID: mdl-4555981

ABSTRACT

Twelve chronic marijuana users received triangle up(9)-tetrahydrocannabinol by smoking. The magnitude of their pulse increment was highly correlated with their subjective experiences. Three of the 12 subjects subsequently received triangle up(9)-tetrahydrocannabinol labeled with carbon-14; the time course of its concentration in plasma was highly correlated with the pulse increment. Subjective symptoms, however, appeared later and dissipated more slowly.


Subject(s)
Cannabis/administration & dosage , Phytotherapy , Adult , Autoradiography , Carbon Isotopes , Clinical Trials as Topic , Dronabinol/administration & dosage , Dronabinol/blood , Dronabinol/pharmacology , Dronabinol/urine , Emotions/drug effects , Humans , Male , Placebos , Pulse/drug effects
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