ABSTRACT
Changes in bacteriological indices through the square of the wound of chemical origin under local impact of the silver nanoparticles (NP), stabilized by 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol) and polyvinylpyrrolidone were studied. The wounds of submandibular region were simulated in white rats, using injection of 10% solution of calcium chloride with further opening of necrotic foci and open management of the wound. Beginning from the fifth day, every day the wound was irrigated with liquid, which have contented the stabilized NP of the silver, 0.05% water solution of chlorhexidine or isotonic solution of the the sodium chloride (control). There was established, that the silver NP impact antiseptically and regenerative while the wound treatment, and reduce during 10 days microbial contamination of exudate in 24 times, the wound square--in three times in comparison with original indices. These changes were identical to those while application of chlorhexidine.
Subject(s)
Anti-Infective Agents, Local/pharmacology , Metal Nanoparticles/therapeutic use , Silver/pharmacology , Soft Tissue Infections/drug therapy , Wound Infection/drug therapy , Animals , Bacterial Load , Calcium Chloride , Chlorhexidine/pharmacology , Male , Mandible/drug effects , Mandible/microbiology , Mandible/pathology , Picolines/chemistry , Povidone/chemistry , Rats , Rats, Wistar , Soft Tissue Infections/chemically induced , Soft Tissue Infections/microbiology , Soft Tissue Infections/pathology , Treatment Outcome , Wound Healing/drug effects , Wound Infection/chemically induced , Wound Infection/microbiology , Wound Infection/pathologyABSTRACT
The dynamic of mexidol's (3-oxipyridine derivate) influence on rats' thymic cells was studied under the conditions of 30-days hypokinesia. It was shown, that changes of thymic cells' content under the chronic hypokinesia developed in some stages. The prevent administration of mexidol (100 mg/kg of body weight) modified the lymphoid cells' migration. The remedy's effects on quantitative parameters of thymic cell's populations depended on stress stage and were synergic to natural adaptive processes. The most expressed mexidol's normalizing effect on thymic cells was marked on the 30th day of hypokinesia.
Subject(s)
Hypokinesia/pathology , Picolines/pharmacology , Psychotropic Drugs/pharmacology , Thymus Gland/drug effects , Animals , Blood Cells/drug effects , Bone Marrow/drug effects , Bone Marrow Cells , Cell Movement/drug effects , Chronic Disease , Male , Rats , Spleen/cytology , Spleen/drug effects , Thymus Gland/cytology , Time FactorsABSTRACT
The chronic stress is characterized by the disintegration of nonspecific resistance's mechanisms, that causes the development of immunodepression. Thymopentin exerts an adaptive effect by means of the removal of disintegration of cell reactions in lymphoid organs, polymorphonuclear leukocytes and antioxidant enzymes.
