Binge eating behavior and incentive motivation with a cafeteria diet.

Binge-like eating behavior (BLE) has been characterized as an eating disorder in which subjects have an enhanced intake of food, mainly fats. However, intake of fats and carbohydrates may have differential effects on motivation. Previously it was shown that BLE produces an increase in operant responding for vegetable shortening, but others were unable to replicate the finding using sucrose as the reinforcer. Our aim was to determine if BLE behavior induced with a cafeteria-like diet (CaLD) with several options with fat content would produce an increment in performance. Male Wistar rats were trained under an exponential progressive ratio schedule of sucrose reinforcement; thereafter, the limited access model was used to induce BLE using CaLD options. Finally, subjects were tested for increments in break points (BPs) in the progressive ratio schedule. Rats with intermittent access to CaLD options showed a clear BLE with an escalation in their intake; however they showed compensatory decrements of chow intake that rendered a similar body weight gain to a continuous access group. Although we were unable to observe an increase in BPs after BLE we were able to observe a protection against the decrements of BP previously observed with sugar. Different mechanisms for processing high fat and high carbohydrate reinforcers are variables worth exploring to gain a better understanding of BLE behavior in rodent models.

Dissociation between binge eating behavior and incentive motivation.

Binge-like eating behavior (BLE) has been characterized as an eating disorder in which subjects have an enhanced intake of food, mainly fats. However, intake of fats and carbohydrates may have differential effects on motivation. Previously it was shown that BLE produces an increase in operant responding for vegetable shortening. Our aim was to determine if BLE behavior induced with a sucrose solution would produce an increment in performance for sucrose reinforcers. Male Wistar rats were trained under an exponential progressive ratio schedule of sucrose reinforcement; thereafter, the limited access model was used to induce BLE. Finally, subjects were tested for increments in break points (BPs) in the progressive ratio schedule. We were unable to observe an increase in BPs after BLE. No increments in BPs were observed when a distinctive flavor (vanilla-flavored sucrose) was correlated with BLE induction and reinforcement, or when different types of ratio progression in the operant schedules were employed. However, rats adjusted their BPs according to reinforcer concentration after BLE induction, demonstrating that valuation (cost/benefit decision) of reinforcers was intact. Extent of training, alterations of reward processing after extended exposure to sucrose, and different mechanisms for processing high fat and high carbohydrate reinforcers are variables worth exploring to gain a better understanding of BLE behavior in rodent models.