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1.
Eur J Paediatr Dent ; 21(4): 299-302, 2020 Dec.
Article in English | MEDLINE | ID: mdl-33337906

ABSTRACT

AIM: Aim of this retrospective cohort study was to assess the frequency and severity of dental caries (DC) among foster care children in the city of Turin, in North West Italy, and to compare these data with those of a general paediatric population. MATERIALS AND METHODS: From May 2016 to September 2018, 75 paediatric subjects between the age of 4 and 12, located in 11 residential child care communities were recruited. Instructions were provided concerning oral health, caries and correlation with dietary habits. Oral and dental examination were carried out to establish frequency and severity of caries (not-penetrating, nPC, corresponding to the International Caries Detection and Assessment System (ICDAS) codes: 1-4, vs. penetrating, PC, corresponding to ICDAS codes: 5-6). Decayed, missed, filled teeth (DMFT) index was used. Data for comparison were acquired from the WHO Collaboration Center For Epidemiology and Community Dentistry of Milan (WHO-CCOMS), belonging to a nationwide sample of 2,141 Italian children. RESULTS: Only 13 subjects (17%) were caries-free; 187 caries were identified: 133 were PC, whereas 54 were nPC. Overall, 76% of the caries were found in deciduous teeth. Mean DMFT was 3.43 (D = 2.97; M = 0.24; F = 0.22). When the study data were compared to those from WHO-CCOMS, a significantly higher DMFT (3.43 vs 0.96; p <0.00001) and D (2.97 vs 0.62; p <0.00001) was detected. CONCLUSION: A significant higher frequency of caries in foster care children in Turin, Italy compared to the general population was detected.


Subject(s)
Dental Caries , Child , Cross-Sectional Studies , DMF Index , Dental Care , Dental Caries/epidemiology , Humans , Italy/epidemiology , Oral Health , Prevalence , Retrospective Studies
3.
Mutat Res ; 172(1): 29-36, 1986 Oct.
Article in English | MEDLINE | ID: mdl-3531835

ABSTRACT

Nineteen 2-halogeno-acetamides, -propanamides, and -iso-butyramides and four related epoxyamides were tested as mutagens for Salmonella typhimurium TA100. Mutagenic activity was observed in strictly selected 2-halogenoamides and in all epoxyamides. The effectiveness of 2-halogenoamides depends upon: the character of the carbon carrying the halogen (1 degree, 2 degrees, 3 degrees); the nature of the halogen (Br, Cl); the substitution at nitrogen. Some considerations concerning the selectivity observed are presented.


Subject(s)
Amides/toxicity , Mutagens , Propionates/toxicity , Salmonella typhimurium/drug effects , Alkylating Agents , Animals , Biotransformation , Bromine/toxicity , Epoxy Compounds , Magnetic Resonance Spectroscopy , Microsomes, Liver/metabolism , Mutagenicity Tests , Rats , Structure-Activity Relationship
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