Subject(s)
Anticoagulants/therapeutic use , Decision Support Techniques , Fibrinolytic Agents/therapeutic use , Hospitalization , Practice Patterns, Physicians' , Venous Thromboembolism/prevention & control , Aged , Aged, 80 and over , Attitude of Health Personnel , Awareness , Female , Guideline Adherence , Health Knowledge, Attitudes, Practice , Humans , Male , Practice Guidelines as Topic , Predictive Value of Tests , Prospective Studies , Risk Assessment , Risk Factors , Venous Thromboembolism/diagnosis , Venous Thromboembolism/etiologySubject(s)
Anticoagulants/therapeutic use , Aspirin/therapeutic use , Atherosclerosis/epidemiology , Fibrinolytic Agents/therapeutic use , Venous Thromboembolism/drug therapy , Aged , Aged, 80 and over , Atherosclerosis/mortality , Female , Humans , Incidence , Kaplan-Meier Estimate , Male , Middle Aged , Recurrence , Retrospective Studies , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome , Venous Thromboembolism/epidemiology , Venous Thromboembolism/mortalityABSTRACT
AIM: The aims of this study were: 1) to quantify endothelial function by flow-mediated dilation (FMD) and atherosclerotic vascular lesions by intima-media thickness (IMT) in migraine sufferers without any of the common atherosclerotic risk factors, comparing them with paired controls; 2) to evaluate their potential autonomic function impairment; and 3) to seek any correlations with vascular modifications. METHODS: Twenty patients suffering from migraine and 20 matched controls were studied, using echo-color-Doppler imaging to measure IMT in the carotid district and FMD of the brachial artery in the non-dominant arm. Autonomic function was studied using the Tilt, Lying-to-Standing, Valsalva, Hand grip, Deep breath, Stroop and Sweat tests. RESULTS: Migraine sufferers had lower FMD and higher IMT values than controls. The former also had autonomic changes revealed by the Tilt, Valsalva, Hand Grip, Deep Breath and Stroop tests, which correlated with their reduced FMD. CONCLUSION: Autonomic dysfunctions modify vascular reactivity in migraine sufferers and this type of change can probably determine endothelial dysfunction and intima-media thickening.