ABSTRACT
Malignant transformation in leiomyoma is rare, with a few documented cases of sarcomatous transformation in leiomyomas. However, carcinosarcomatous transformation in leiomyomas is extremely infrequent. A 45-year-old female presented with a mass sensation per abdomen for the last five months. An abdominal ultrasound revealed multiple uterine fibroids. Contrast-enhanced magnetic resonance imaging revealed a large multiloculated abdominopelvic mass arising from the fundus of the uterus, along with multiple smaller subserosal fibroids. A total abdominal hysterectomy with bilateral salpingectomy was performed. Grossly, the uterus was bosselated with multiple subserosal fibroids. The larger degenerated fibroid showed a smooth outer surface; however, the cut surface was predominantly cystic and filled with necrotic material. Microscopically and immunohistochemically, the larger mass showed a high-grade biphasic tumor comprising carcinomatous and sarcomatous components with the peripheral solid areas showing compressed smooth muscle bundles representing the residual leiomyomatous areas. A final diagnosis of carcinosarcomatous transformation in leiomyoma was rendered. The index report highlights the significance of systematic gross and microscopic examination of all the uterine masses in patients with multiple leiomyomata.
Subject(s)
Carcinosarcoma , Leiomyoma , Uterine Neoplasms , Female , Horses , Humans , Animals , Cattle , Leiomyoma/diagnosis , Leiomyoma/surgery , Leiomyoma/pathology , Uterine Neoplasms/diagnosis , Uterine Neoplasms/surgery , Uterine Neoplasms/pathology , Uterus/pathology , Hysterectomy , Carcinosarcoma/diagnosis , Carcinosarcoma/surgery , Carcinosarcoma/pathology , Cell Transformation, Neoplastic/pathologyABSTRACT
AIM: The objective was to evaluate the bone mineral density (BMD) and bone mineral content (BMC) in children affected with molar incisor hypomineralization (MIH) using dual-energy X-ray absorptiometry (DEXA) scan. MATERIALS AND METHODS: The study comprised a total of 30 children aged 6-10 years. Fifteen children were affected with MIH (moderate and severe variety) diagnosed using the European Academy of Paediatric Dentistry 2003 criteria, and remaining 15 children not affected with MIH serve as a control group. DEXA scan was done in all the selected children under standard conditions. RESULTS: A positive association was seen between childhood illness and MIH. The mean subtotal BMC (grams) in MIH and control group was 633 ± 80.05 and 670.33 ± 166.41, respectively, whereas mean subtotal BMD (g/m2) was 1.00 and 0.87 ± 0.35, respectively, with no statistically significant difference between two groups. BMD and BMC at the lumbar spine and thoracic spine locations were also did not vary significantly between MIH-affected children and controls. CONCLUSION: Childhood illnesses were more common in MIH-affected children compared to controls. Bone maturation parameters (BMD, BMC) do not differ between MIH affected and control children.
