Structure of the perception of health professionals regarding the quality of health services in the context of COVID-19.

BACKGROUND: The health emergency caused by COVID-19 revealed the shortcomings of health services (HS), but little is known about how this has impacted the mental health of health professionals (HP) when perceiving these difficulties. METHODS: Data were collected through an online survey administered to HP in Lima (Peru) between May and July 2020. A questionnaire was applied to identify perceived quality of health services (PHQS). A network analysis was performed, and the centrality measures of the variables were calculated and plotted. RESULTS: A total of 507 HP completed the survey. In the network analysis of PHQS, four clusters were identified: (A) "empathy" and "recognition of competencies," (B) "logistical support," "protection," "personal early diagnosis," and "early family diagnosis"; C) "professional competence with regard to their treatment and treatment for their family," "equipment for their treatment and treatment for their family," "professional competence with regard to their treatment and treatment for their family," and "institutional support for them and their family"; and D) "fear of being infected or infecting their family," "fear of dying or death of a family member," "knowledge stability," "job burnout," and "role change." The variables of PHQS with the greatest centrality were "equipment for their treatment," "equipment for the treatment of their family," and "early family diagnosis." CONCLUSIONS: The structure of the PHQS of HP describes direct and indirect influences of different variables in the context of COVID-19.

Características de la personalidad relacionadas con el proceso de mentoría / Personality characteristics related to the mentoring process

Se realiza una revisión narrativa sobre la relación entre el proceso de mentoría (o mentorazgo) y la personalidad de mentores y mentoreados. Se encontró que las condiciones que favorecen un desarrollo satisfactorio del proceso son bajo nivel de neuroticismo, conciencia elevada, alta extraversión, agradabilidad intermedia, apertura intermedia, locus de control interno, bajo narcisismo y concordancia entre los niveles de neuroticismo del mentor y del mentoreado. En el caso de la autovigilancia los resultados son contradictorios. En vista de la escasez de estudios sobre la relación entre personalidad y mentoría, se recomienda investigaciones específicas en torno a este tema, particularmente en el ámbito de la educación médica.

A narrative review about the relationship between the mentoring (mentorship) process and the personality of mentors and mentees was made. It was found that the conditions that favor a successful mentoring process are low neuroticism levels, high consciousness, high extraversion, intermediate agreeableness, intermediate openness, internal locus of control, low narcissism, and concordance between neuroticism levels of mentor and mentee. In the case of self-monitoring, the results are contradictory. In view of the scarcity of studies about the relationship between personality and mentoring, it is recommended to carry out specific research on this topic, particularly in the medical education field.

Relationship between depression, anxiety, and perceived stress in health professionals and their perceptions about the quality of the health services in the context of COVID-19 pandemic.

BACKGROUND: The health emergency caused by COVID-19 revealed the shortcomings of health services (HS), but little is known about how this has impacted the mental health of health professionals (HP). METHODS: Data were collected through an online survey administered to HP in Lima (Peru) between May and July 2020. Instruments were applied to evaluate anxiety, depression, perceived stress (PS), and perceived quality of health services (PQHS). RESULTS: A total of 507 HP completed the survey. In the multivariate analysis, younger age and female gender were related to anxiety, depression, and PS (all with p < .001). The most relevant unfavorable PQHS associated with anxiety were competence of other HP to care for HP if infected (p = .002) and support for HP or their families in the event of becoming infected (p = .001); the most relevant unfavorable PHQS associated with depression were equipment to care for HP and their families if infected (p = .003); support for HP or their families if infected (p < .001); fear of HP and/or family members being infected or dying (p = .006); and HP' recognition of their competencies (p < .001); and the most relevant unfavorable PHQS associated with PS were support for HP or their families if infected (p < .001) and instability of knowledge (p = .027). CONCLUSIONS: There was an association between impaired mental health and PQHS scores among HP. This study shows the need for HP to express their concerns about how HS are supporting their safety and that of their family during health emergencies.

Relación entre la presencia de síntomas premenstruales y los niveles de depresión medidos con la Escala de Depresión Postnatal de Edimburgo en mujeres con menos de un año postparto / Relation between premenstrual symptoms and levels of depression measured by the Edinburgh Postnatal Depression Scale in women within their first year postpartum year

RESUMEN Objetivo: Evaluar la relación entre cada síntoma del trastorno disfórico premenstrual (TDPM) y los niveles de depresión postparto (DPP). Método: Se realizó un análisis secundario de una base de datos de 321 mujeres evaluadas transversalmente en el primer año postparto, determinando la presencia de síntomas del TDPM según los criterios del DSM-IV, y los niveles de DPP, mediante la Escala Edimburgo de Depresión Postnatal (EPDS). Mediante un análisis bivariado se determinaron las variables relacionadas significativamente con los puntajes de la EPDS y, con un análisis multivariado, se configuró el mejor modelo predictivo. Resultados: El análisis bivariado identificó a cefalea (coeficiente=3,26; p=0,002) y sensación de agobio (coeficiente=4,95; p=0,003) como asociadas a un mayor puntaje en la EPDS, más que el TDPM (coeficiente=2,52; p<0,001) como variable única. Otras variables asociadas fueron antecedente de depresión (coeficiente=2,42; p<0,001), presencia de pareja (coeficiente=1,54; p=0,041) y aborto (coeficiente=1,44; p=0,034). El modelo multivariado que mejor predice los puntajes de la EPDS incluye sensación de agobio, cefalea, antecedente de depresión mayor, presencia de pareja, antecedente de aborto y edad. Conclusiones: Los hallazgos arriba descritos podrían utilizarse para formular encuestas de tamizaje en gestantes, considerando además factores de riesgo tales como edad y antecedentes de depresión y aborto.

SUMMARY Objective : To evaluate the relationship between each symptom of premenstrual dysphoric disorder (PMDD) and the levels of postpartum depression (PPD). Methods: A secondary analysis of a database of 321 women, evaluated cross-sectionally in the first postpartum year was conducted, determining the presence of PMDD symptoms according to the DSM-IV criteria, and the levels of PPD, using the Edinburgh Postnatal Depression Scale (EPDS). A bivariate analysis determined the variables significantly related to the EPDS scores, while a multivariate analysis helped to configure the best predictive model. Results: According to the bivariate analysis, headache (coefficient=3,26; p=0,002) and feeling overwhelmed (coefficient=4,95; p=0,003) are associated with higher scores in the EPDS, even more so than PDDS (coefficient=2,52; p<0,001) as a single variable. Other associated variables were history of depression (coefficient=2,42; p<0,001), having a partner (coefficient=1,54; p=0,041) and abortion (coefficient=1,44; p=0,034). The multivariate model that best predicts EPDS scores includes feeling overwhelmed, headache, history of major depression, having a partner, history of abortion and age. Conclusions: The above findings are significantly related to EPDS scores, which could be used to design screening scales for pregnant women, also taking into account other risk factors, such as age and past history of depression and abortion.

Traducción y adaptación cultural del Cuestionario sobre el Uso Problemático de Internet para la población peruana / Translation and cultural adaptation of the Questionnaire on the Problematic Use of the Internet for the Peruvian population

RESUMEN Objetivo: Adaptar el Cuestionario sobre el Uso Problemático de Internet (PIUQ) para su utilización en el Perú. Material y Métodos: La traducción al español y la adaptación cultural del PIUQ siguieron un proceso sistematizado que incluyó la traducción directa, la evaluación por juicio de expertos y la retrotraducción, y culminó con la aprobación final de los creadores de la escala. Para cada uno de los 18 ítems, un primer comité de expertos evaluó en la versión preliminar la comprensibilidad, aceptabilidad, relevancia y el conjunto de respuestas; posteriormente, un segundo comité, examinó en la versión final los rasgos de claridad, pertinencia y relevancia. Se calculó la V de Aiken para cada uno de los diferentes aspectos evaluados en los 18 ítems. Resultados: En la versión preliminar, la V de Aiken tuvo valores bajos para la comprensibilidad de los ítems 1, 3, 4, 6 y 16, y para el conjunto de respuestas del ítem 4. El análisis del primer comité de expertos produjo modificaciones en los ítems 1, 4 y 16 de la dimensión de obsesión, 5 y 8 de negligencia, y 15 de trastorno de control. La evaluación por parte del segundo comité de expertos resultó en valores adecuados de V de Aiken en todos los aspectos de los 18 ítems. Conclusiones: La versión peruana final así obtenida demostró estar alineada a los fines del cuestionario original, sin alterar el significado de los ítems.

SUMMARY Objective : To adapt the Problem Internet Use Questionnaire (PIUQ) for its utilization in Peru. Material and Methods : The translation and cultural adaptation of the PIUQ followed a systematic process that involved direct translation, evaluation and judgment by expert committees and back-translation, culminating with the final approval by the scale creators. For each of the 18 items, a first group of experts assessed comprehensibility, acceptability, relevance and quality of the response set in the preliminary version; subsequently, a second group of experts, evaluated clarity, relevance and pertinence in the final version. Aiken's V was calculated for each of the different features evaluated in the 18 items. Results : In the preliminary version, Aiken's V had low values for the comprehensibility of items 1, 3, 4, 6 and 16, and for the response set of item 4. The analysis of the first expert committee led to modifications in items 1, 4 and 16 of the obsession dimension, 5 and 8 of neglect, and 15 of control disorder. The evaluation by the second expert committee resulted in adequate Aiken V values for all aspects of the 18 items. Conclusions : The final Peruvian version thus obtained proved to be aligned to the purposes of the original questionnaire, without altering the meaning of the items.

Estudios psicométricos de los instrumentos en español para la detección de trastornos mentales comunes: una revisión / Psychometric studies of instruments in Spanish for the detection of common mental disorders: A review

RESUMEN El objetivo de esta revisión es describir las características psicométricas de las versiones en español de instrumentos utilizados en la detección de trastornos mentales comunes, sobre la base de una búsqueda sistemática en PubMed y Google Académico. Se identificaron los siguientes instrumentos con información pertinente: General Health Questionnaire (GHQ-12 y GHQ-28), Hospital Anxiety and Depression Scale (HADS), Escala de Salud Personal (ESP), Self-Reporting Questionnaire (SRQ-20), Escala de Malestar Psicológico de Kessler (K-6 y K-10), Patient Health Questionnaire (PHQ), Escala de Edimburgo (EPDS), Dep5, Anx5 y Symptom Checklist (SCL-90 y SCL-90-R). Los instrumentos más estudiados fueron el GHQ y la HADS. La mayoría de estudios fueron realizados en España. En Perú se evaluaron el SRQ-20, la ESP, la K-6, la K-10 y el GHQ-28. Las propiedades psicométricas descritas incluyen: consistencia interna, estructura factorial, área bajo la curva Receiver Operating Characteristic (abcROC), sensibilidad, especificidad e índice de Youden (J). El J de los instrumentos estudiados estuvo entre 0,2389 y 0,767 y el abcROC, entre 0,758 y 0,933. Esta revisión puede asistir en la elección de instrumentos psicométricos en español para la realización de estudios y la práctica clínica, así como en la identificación de necesidades de investigación sistemática en torno al tema.

SUMMARY The objective of this review is to describe the psychometric characteristics of the Spanish versions of instruments for the detection of common mental disorders, on the basis of a systematic search carried out in PubMed and Google Scholar. The following instruments with pertinent psychometric information were identified: General Health Questionnaire (GHQ-12 and GHQ-28), Hospital Anxiety and Depression Scale (HADS), Personal Health Scale (PHS), Self-Reporting Questionnaire (SRQ -20), Kessler Psychological Distress Scale (K-6 and K-10), Patient Health Questionnaire (PHQ), Edinburgh Scale (EPDS), Dep5, Anx5 and Symptom Checklist (SCL-90 and SCL-90-R). The most studied instruments were GHQ and HADS. Most of the studies were carried out in Spain. In Peru, SRQ-20, PHS, K-6, K-10 and GHQ-28 were evaluated. The psychometric properties described include internal consistency, factorial structure, area under the Receiver Operating Characteristic curve (AUC), sensitivity, specificity and Youden index (J). J of the instruments were between 0.2389 and 0.767, and the AUC, between 0.758 and 0.933. This review could help to choose psychometric instruments in Spanish for studies and clinical practice, as well as to systematically identify research needs about this topic.

Depression and anxiety symptoms and perceived stress in health professionals in the context of COVID-19: Do adverse childhood experiences have a modulating effect?

BACKGROUND: Adverse childhood experiences (ACE) have a great impact on mental health outcomes of adults. However, little is known whether ACE may act as modulators of the mental health of health professionals caring for patients with COVID-19. METHODS: Data were collected through an online cross-sectional survey administered to health professionals in Lima (Peru) between May and July 2020. The survey included standardized self-assessment instruments for anxiety, depression, acute stress (AS) and history of ACE. RESULTS: A total of 542 health professionals completed the survey. Caring for patients with COVID-19 was significantly associated with depression and anxiety and when caring for patients with COVID-19 was combined with a history of early sexual abuse, its effect on the risk of anxiety increased (OR = 7.71, p = .010). Mental health problems were associated with female gender in almost all the analyses and with the majority of ACEs. CONCLUSIONS: Health workers in the context of the COVID-19 pandemic presented a high risk of mental health disorders. Antecedents of sexual abuse acted as a potentiating factor of anxiety in professionals providing COVID-19 care. These findings suggest that the burden of ACE modulates mental health problems in health professionals during the pandemic.

Overestimation of Postpartum Depression Prevalence Based on a 5-item Version of the EPDS: Systematic Review and Individual Participant Data Meta-analysis.

OBJECTIVE: The Maternal Mental Health in Canada, 2018/2019, survey reported that 18% of 7,085 mothers who recently gave birth reported "feelings consistent with postpartum depression" based on scores ≥7 on a 5-item version of the Edinburgh Postpartum Depression Scale (EPDS-5). The EPDS-5 was designed as a screening questionnaire, not to classify disorders or estimate prevalence; the extent to which EPDS-5 results reflect depression prevalence is unknown. We investigated EPDS-5 ≥7 performance relative to major depression prevalence based on a validated diagnostic interview, the Structured Clinical Interview for DSM (SCID). METHODS: We searched Medline, Medline In-Process & Other Non-Indexed Citations, PsycINFO, and the Web of Science Core Collection through June 2016 for studies with data sets with item response data to calculate EPDS-5 scores and that used the SCID to ascertain depression status. We conducted an individual participant data meta-analysis to estimate pooled percentage of EPDS-5 ≥7, pooled SCID major depression prevalence, and the pooled difference in prevalence. RESULTS: A total of 3,958 participants from 19 primary studies were included. Pooled prevalence of SCID major depression was 9.2% (95% confidence interval [CI] 6.0% to 13.7%), pooled percentage of participants with EPDS-5 ≥7 was 16.2% (95% CI 10.7% to 23.8%), and pooled difference was 8.0% (95% CI 2.9% to 13.2%). In the 19 included studies, mean and median ratios of EPDS-5 to SCID prevalence were 2.1 and 1.4 times. CONCLUSIONS: Prevalence estimated based on EPDS-5 ≥7 appears to be substantially higher than the prevalence of major depression. Validated diagnostic interviews should be used to establish prevalence.

Selección de ítems para el desarrollo de un instrumento de evaluación de severidad de trastornos mentales en pacientes sin psicosis o déficit cognitivo / Item selection for the development of a severity assessment instrument for mental disorders in patients without psychosis or cognitive deficit

Objetivo: Seleccionar los ítems más relevantes para la creación de un instrumento de evaluación global de pacientes psiquiátricos ambulatorios sin psicosis ni déficit cognitivo. Material y Métodos: Se aplicaron 60 ítems, procedentes de diferentes escalas que evalúan principalmente severidad de síntomas, discapacidad y calidad de vida, a 313 pacientes con trastornos mentales de la consulta ambulatoria de psiquiatría del Hospital Cayetano Heredia (Lima, Perú). Al mismo tiempo, se evaluó la severidad de su sintomatología mental a través de la Escala de Impresión Clínica Global de Severidad (CGI-S). Se determinaron los ítems más relevantes en base a las cargas factoriales (CF) de cada ítem producto de un análisis factorial policórico y las correlaciones policóricas entre cada ítem y la CGI-S (cCGI). Resultados: Los 11 ítems más relevantes fueron: Calidad de vida global (CF=0,7958, cCGI=-0,4275), Bienestar psicológico (CF=0,7891, cCGI=-0,4507), Tristeza (CF=0,7601, cCGI=-0,4613), Sentimientos negativos (CF=0,7595, cCGI=-0,4269), Angustia (CF=0,7501, cCGI=-0,4824), Libertad y seguridad (CF=0,7402, cCGI=-0,4011), Suicidalidad (CF=0,7147, cCGI=-0,4766), Sentido de vida (CF=0,6998, cCGI=-0,4161), Crecimiento personal (CF=0,6987, cCGI=-0,4198), Espiritualidad, religión y creencias personales (CF=0,6936, cCGI=-0,3925) y Plenitud personal (CF=0,6869, cCGI=-0,4073). Conclusiones: Los 11 ítems seleccionados podrían constituir un instrumento corto de auto-reporte para la evaluación de enfermedad mental.

Objective: To select the most relevant items for the creation of a global evaluation instrument for psychiatric outpatients without psychosis or cognitive impairment. Methods: 313 psychiatric outpatients from Hospital Cayetano Heredia (Lima, Peru) completed 60 items taken from a variety of scales focused on measuring severity of symptoms, disability, and quality of life. At the same time, the severity of their mental symptoms was assessed through the Clinical Global Impressions Scale (CGI-S). The most relevant items were chosen based on each item´s factorial loads (FL) resulting from a polychoric factorial analysis and the polychoric correlations between each item and the CGI-S (CGIc). Results: The 11 most relevant items were: Global perception of quality of life (FL=0.7958, CGIc=-0.4275), Psychological/Emotional wellbeing (FL=0.7891, CGIc=-0.4057), Sadness (FL=0.7601, CGIc=-0.4613), Negative feelings (FL=0.7595, CGIc=-0.4269), Angst (FL=0.7501, CGIc=-0.4824), Freedom and physical safety (FL=0.7402, CGIc=-0.4011), Suicidality (FL=0.7147, CGIc=-0.4766), Life meaning (FL=0.6998, CGIc=-0.4161), Personal growth (FL=0.6987, CGIc=-0.4198), Spirituality and personal beliefs (FL=0.6936, CGIc=-0.3925), and Personal fulfillment (FL=0.6869, CGIc=-0.4073). Conclusion: The 11 selected items could constitute a short self-reporting instrument for the evaluation of mental illness.

Construcción y propiedades psicométricas de la Escala de Ansiedad de Lima de 20 ítems (EAL-20) / Construction and psychometric properties of 20-item Lima Anxiety Scale (LAS-20)

Objetivo: Seleccionar los ítems más representativos de una escala de ansiedad de 130 ítems (Escala de Ansiedad de Lima, EAL-130) para hacer posible la construcción de una versión breve de 20 ítems (EAL-20). Métodos: A partir de los datos del estudio previo de validación de la EAL-130 en 254 pacientes, se utilizó el método de análisis de regresión múltiple para identificar los ítems que mejor predecían los puntajes totales de cada una de 5 subescalas correspondientes a 5 síndromes incluidos en la escala original (ansiedad psíquica, síntomas físicos, pánico, agorafobia y fobia social). Se condujo un análisis factorial de matriz policórica de la nueva escala así generada (EAL-20). Resultados: La EAL-20 tuvo un alfa de Cronbach de 0,8885 y sus 20 ítems cubrieron el 90,38% de la varianza del puntaje total de la EAL-130. En la EAL-20 se identificaron 4 factores correspondientes a ansiedad física, fobia social, ansiedad psíquica y agorafobia. Con un punto de corte de = 10 se obtuvo un equilibrio entre sensibilidad y especificidad para la identificación de un CGI-S= 4. Conclusiones: Los 20 ítems seleccionados para la EAL-20 permiten evaluar 4 dimensiones de ansiedad, con una mínima pérdida de información respecto a la EAL-130; se sugiere usar un punto de corte = 10 como indicador de ansiedad moderada o de severidad mayor.

Objective: To select the most representative items of a 130-item anxiety scale (Lima Anxiety Scale, LAS-130) in order to construct a shorter version of 20 items (LAS-20). Methods: Based on the data of the 254 patients included in the previous validation study of LAS-130, multiple regression analysis was used to identify the items that best predicted the total scores of each of 5 subscales corresponding to 5 syndromes included in the original scale (psychic anxiety, physical symptoms, panic, agoraphobia and social phobia). In addition, a factorial analysis of the polychoric matrix of the new scale (LAS-20) was performed. Results: LAS-20 had a Cronbach's alpha of 0.8885, and its 20 items covered 90.38% of the total score variance of LAS-130. In LAS-20, 4 factors were identified corresponding to physical anxiety, social phobia, psychic anxiety and agoraphobia. Using a cut-off score of =10, equilibrium between sensitivity and specificity was obtained for detection of a CGI-S= 4. Conclusions: The 20 items selected for the LAS-20 allow to evaluate 4 anxiety dimensions with a minimum loss of information when compared to the LAS-130. A cut-off score of = 10 is suggested as an indicator of anxiety of moderate or higher severity.

Construcción de versiones cortas de la Escala de Psicopatología Depresiva para tamizaje de depresión mayor y sus características psicométricas / Construction of short versions of the Depressive Psychopathology Scale for screening of Major Depression and its psychometric features

Objetivos: Seleccionar los mejores ítems de la Escala de Psicopatología Depresiva original de 20 ítems (EPD) para construir versiones cortas a ser usadas en la detección de depresión mayor. Métodos: Usando como estándares de oro el diagnóstico de depresión mayor según la Entrevista Clínica Estructurada para el DSM-IV (Structured Clinical Interview for DSM-IV, SCID) y el diagnóstico clínico realizado por un psiquiatra (DCP), se determinó la combinación óptima de ítems buscando los mayores valores de área bajo la curva ROC (abcROC). Resultados: El abcROC más alta para el diagnóstico de depresión mayor considerando la SCID se obtuvo con una combinación de 4 ítems (EPD-4): fatiga, reactividad del ánimo, anhedonia y tristeza (abcROC=0,9033). Tomando en cuenta el DCP se identificaron 6 ítems (EPD-6): los mismos 4 ítems de la EPD-4 más alteración del sueño y pesadez de extremidades (abcROC=0,8652). Tanto para la SCID como para el DCP, las abcROC de ambas versiones cortas (EPD-4 y EPD-6) mostraron una tendencia (no significativa) a ser superiores a las correspondientes de la EPD de 20 ítems. Conclusiones: Los resultados sugieren que la detección de depresión mayor puede hacerse con versiones más cortas de la EPD sin perder su eficacia diagnóstica

Objectives: To select the best items, out of the 20 of the original Depressive Psychopathology Scale (DPS), in order to construct shorter versions to be used for Major Depression (MD) screening. Method: Using as a gold standards the diagnosis of MD according to the Structured Clinical Interview for DSM-IV (SCID) and a psychiatrist's clinical diagnosis (PCD), the best item combination was determined searching the highest area under the ROC curve value (auROC). Results: The highest auROC value for the MD diagnosis according SCID, were obtained with a combination of 4 items (DPS-4): fatigue, mood reactivity, anhedonia, and sadness (auROC=0.9033); when considering the PCD, 6 items (DPS-6) were identified: the same 4 plus sleep disturbance and overweighed extremities (leaden paralysis) (auROC=0.8652). For SCID and PCD, the auROC of both short versions (DPS-4 and DPS-6) showed a non significant trend to be greater than those corresponding to 20-item DPS. Conclusions: The results suggest that MD screening can be done with shorter versions of DPS without losing its diagnostic efficacy.

Aripiprazol en dosis bajas para somnolencia diurna excesiva asociada a uso de haloperidol: un reporte de caso / Low dose aripiprazole for excessive daytime sleepiness associated with the use of haloperidol: A case report

La somnolencia diurna es un efecto adverso frecuentemente asociado al uso de antipsicóticos en pacientes con esquizofrenia. Presentamos el caso de una mujer de 43 años con esquizofrenia y tratamiento antipsicótico desde hace 24 años, que inicialmente, presentó mala respuesta a antipsicóticos clásicos de baja potencia, llegando a lograr estabilizar los síntomas psicóticos por más de 10 años con uso de haloperidol. Sin embargo, con este tratamiento presentó somnolencia diurna que llegó a ser un efecto adverso importante limitando su funcionalidad y calidad de vida. Luego de añadirse primero 3,75 mg y luego 7,5 mg de aripiprazol, mejoró hasta un 80% la somnolencia sin exacerbación de los síntomas psicóticos

Daily somnolence is a frequent adverse event associated to the use of antipsychotic medication in patients with schizophrenia. We present the case of a 43 years old women with schizophrenia and pharmacological treatment for 24 years, who, at the start of the treatment, showed inadequate response to low potency classical antipsychotics, achieving clinical stability for more than 10 years with the use of haloperidol. However, she presented severe daily somnolence which significantly limited her functionality and quality of life. After the addition of 3.75 mg and later 7.5 mg of aripiprazole the somnolence improved in nearly 80% without exacerbation of psychotic symptoms

Frecuencia de tendencias suicidas (suicidalidad) y factores asociados en mujeres durante el primer año posparto / Frequency of suicidality and associated factors in women during the first postpartum year

Objetivos: Estimar la frecuencia de tendencias suicidas (suicidalidad) y explorar su relación con diversas variables en mujeres atendidas en un hospital público peruano durante el primer año del periodo posparto. Material y Métodos: Se realizó un análisis secundario de datos de un trabajo de investigación realizado en el Hospital Cayetano Heredia (Lima, Perú) que incluía 321 mujeres durante el primer año posparto, con registros de variables sociodemográficas, ginecológicas, clínico-psiquiátricas y de suicidalidad definida como la presencia del síntoma 9 del criterio A de Episodio Depresivo Mayor evaluado mediante la Entrevista Clínica Estructurada para el DSM-IV (Structured Clinical Interview for DSM-IV Disorders, SCID). Resultados: Se encontró una frecuencia de 15,58 % (IC 95%: 11,79-20,01%) de suicidalidad en mujeres durante el primer año posparto. El análisis bivariado mostró relación significativa entre la presencia de suicidalidad y depresión mayor (OR = 14,52; p <0,001), trastorno obsesivo-compulsivo (OR = 3,96; p= 0,001), trastorno disfórico premenstrual (OR=3,25; p=0,002) y episodio maniaco o hipomaniaco previo (OR=2,12; p=0,025). Asimismo, el análisis multivariado encontró relación significativa con status de separada/divorciada (OR = 6,96; p = 0,027), abortos previos (OR = 2,92; p = 0,006), sueño menor de 6 horas (OR=5,34; p=0,003) y lactancia materna (OR=0,15; p=0,004). Conclusiones: Las tendencias suicidas en mujeres con menos de un año posparto fueron detectadas en 15,58% de la muestra y se relacionaron con una serie de variables de diversa índole, las cuales deben ser tenidas en cuenta para eventuales intervenciones preventivas y/o de atención clínica focalizada.

Objectives: To estimate the frequency of suicidality and to explore its relation with different variables in women seen in a Peruvian public hospital during their first year of their postpartum period. Material and Methods: A secondary data analysis of a research study carried out in the Hospital Cayetano Heredia (Lima, Peru) was conducted on 321 women seen during their first postpartum year, with focus on sociodemographic, psychiatric, gynecological and suicidality variables. Suicidality was defined as the presence of symptom 9 of criterion A of a Major Depressive Episode assessed through the Structured Clinical Interview for DSM-IV Disorders (SCID). Results: Suicidality was found in 15.58% (95% CI: 11.79-20.01%) of the sample. Bivariate analyses showed a significant relationship between suicidality and major depression (OR = 14.52, p <0.001), obsessive-compulsive disorder (OR = 3.96, p = 0.001), premenstrual dysphoric disorder (OR=3.25, p = 0.002) and previous manic or hypomanic episode (OR = 2.12, p = 0.025). In addition, multivariate analysis found a significant relationship with being separated / divorced (OR = 6.96, p = 0.027), previous abortions (OR = 2.92, p = 0.006), sleep of less than 6 hours (5.34, p = 0.003) and breastfeeding (OR = 0.15, p = 0.004). Conclusions: The suicidality in women with less than one year postpartum had a frequency of 15.58% and was related to a series of variables to be taken into account for eventual preventive and/or focused clinical interventions.

Feasibility, acceptability and clinical utility of the Cultural Formulation Interview: mixed-methods results from the DSM-5 international field trial.

BackgroundThere is a need for clinical tools to identify cultural issues in diagnostic assessment.AimsTo assess the feasibility, acceptability and clinical utility of the DSM-5 Cultural Formulation Interview (CFI) in routine clinical practice.MethodMixed-methods evaluation of field trial data from six countries. The CFI was administered to diagnostically diverse psychiatric out-patients during a diagnostic interview. In post-evaluation sessions, patients and clinicians completed debriefing qualitative interviews and Likert-scale questionnaires. The duration of CFI administration and the full diagnostic session were monitored.ResultsMixed-methods data from 318 patients and 75 clinicians found the CFI feasible, acceptable and useful. Clinician feasibility ratings were significantly lower than patient ratings and other clinician-assessed outcomes. After administering one CFI, however, clinician feasibility ratings improved significantly and subsequent interviews required less time.ConclusionsThe CFI was included in DSM-5 as a feasible, acceptable and useful cultural assessment tool.

Avances en el tratamiento farmacológico del trastorno obsesivo-compulsivo / Advances in the pharmacological treatment of obsessive-compulsive disorder

Los antidepresivos serotoninérgicos, la farmacoterapia de primera lnea para el trastorno obsesivo-compulsivo (TOC), producen una respuesta cl¡nica favorable en 40-60% de los pacientes. Los medicamentos con eficacia en el tratamiento del TOC, seg£n los diversos mecanismos de acción, son: 1) sustancias que influyen sobre laserotonina: antidepresivos serotonin‚rgicos (inhibidores selectivos de la recaptación de serotonina y clomipramina), bloqueadores de los receptores 5-HT3 (ondansetrón y granisetr¢n) y antagonistas 5-HT1A (pindolol); 2) antipsicóticos: aripiprazol, risperidona y haloperidol; 3) anticonvulsivantes / estabilizadores del  nimo: lamotrigina; 4) farmacos relacionados con la función glutamatórgica: memantina, N-acetilciste¡na y ketamina; 5) anti-inflamatorios: celecoxib; 6) opi ceos: morfina; 7) farmacos que aumentan la funci¢n colinérgica; y 8) anti-andrógenos. Es de esperarse queen el futuro crezca el repertorio de alternativas farmacológicas para el tratamiento de esta entidad cl¡nica.

Serotoninergic antidepressants, the first line of pharmacotherapy for obsessive-compulsive disorder (OCD), induce afavorable clinical response in 40-60% of patients. Drugs that have shown efficacy for OCD treatment, on the basis of different mechanisms of action, are: 1) substance that work on serotonin: serotoninergic antidepressants (selective serotonin reuptake inhibitors and clomipramine), 5-HT3 receptor blockers (ondansetron and granisetron), and 5-HT1A antagonists (pindolol); 2) antipsychotic drugs: aripiprazole, risperidone and haloperidol; 3) anticonvulsant drugs / mood stabilizers: lamotrigine; 4) glutamatergic function-related drugs: memantine, N-acetylcysteine and ketamine; 5) anti-inflammatory drugs: celecoxib; 6) opioid drugs: morphine; 7) drugs that increase cholinergic function; 8) anti-androgen drugs. The repertoire of pharmacological alternatives for the treatment of OCD is expected to grow in the future.

Estructura de la sintomatología psiquiátrica según el SRQ-18 en pacientes ambulatorios con trastornos mentales evaluados en un hospital general de Lima / Structure of psychiatric symptoms according to the SRQ-18 in outpatients with mental disorders assessed in a general hospital in Lima

Objetivos: describir la estructura de la sintomatología psiquiátrica evaluada mediante el instrumento SRQ-18 enpacientes ambulatorios con trastornos mentales de un hospital general de Lima. Métodos: Utilizando un registrode datos demográficos y clínicos de 210 pacientes de consultorio externo de psiquiatría del Hospital CayetanoHeredia (Lima, Perú), se exploraron los vínculos entre síntomas psiquiátricos del cuestionario SRQ-18 mediantecorrelaciones tetracóricas graficadas a través de redes generadas con el programa NodeXL...

Objectives: to describe the structure of psychiatric symptomatology evaluated through SRQ-18 in outpatients withmental disorders in a general hospital in Lima. Methods: Using the demographic and clinical information from filesof 210 psychiatric out-patients in the Hospital Cayetano Heredia (Lima, Peru), the connections between psychiatricsymptoms of SRQ-18 questionnaire evaluated by means of tetrachoric correlations were graphically representedin a network generated with the NodeXL program...