Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
Add more filters










Database
Language
Publication year range
2.
Toxins (Basel) ; 15(12)2023 12 01.
Article in English | MEDLINE | ID: mdl-38133184

ABSTRACT

Venom immunotherapy (VIT) protects up to 98% of treated Hymenoptera allergy patients from reactions with new stings. A correct diagnosis with the identification of the venom causing the allergic reaction is essential to implementing it. The knowledge of the Hymenoptera foraging habits when the sting takes place in a food environment would allow the culprit insect to be known. Images of Hymenoptera occurring in environments where there was human food were recorded in Spain, including the date of the image, the place description and its geolocation. The insects' genus and species were identified by an entomologist. Results: One hundred and fifty-five images depicting 71 insects were analyzed. The identified insects were Vespula (56), Vespa (7), Polistes (4), Cerceris (2), Bombus (1) and Apis (1). Most (97.1%) of the images were obtained in summer and early autumn, outdoors in terraces (64%). Meat was the food associated with 47.9% of the images. In protein-rich foods, Vespula was found in 89%. Conclusions: Vespula was the main Hymenoptera associated with food environments in our country (78.87%), and in most of the cases (71%), the food involved is a source of protein, such as meat or seafood. In that environment, the probability that the insect is a Vespula would be 89%.


Subject(s)
Bee Venoms , Hymenoptera , Hypersensitivity , Insect Bites and Stings , Wasps , Humans , Bees , Animals , Hypersensitivity/diagnosis , Allergens , Meat , Wasp Venoms
3.
Int Arch Allergy Immunol ; 182(5): 447-454, 2021.
Article in English | MEDLINE | ID: mdl-33588417

ABSTRACT

BACKGROUND: Lipid transfer proteins (LTPs) syndrome is an important cause of multiple plant food allergy in the Mediterranean area. The effectiveness of sublingual immunotherapy (SLIT) with the LTP Pru p 3 extract has been little investigated in the real-world setting. This study aimed to investigate the outcome of Pru p 3 SLIT in real-life patients with LTP syndrome with/without concurrent reactions to peanut and/or nuts. METHODS: This was a prospective real-life study including all patients diagnosed with LTP allergy and treated with Pru p 3 SLIT between 2011 and 2018 in a tertiary hospital in Spain. Patients underwent open oral food challenge (OFC) tests for unpeeled peach and nuts/peanuts 1 year after the treatment started to assess food tolerance. A control group of patients diagnosed with LTP allergy who refused treatment with immunotherapy were included. Severity of symptoms and diet avoidance was recorded in both groups. RESULTS: Twenty-nine patients with a median age of 24.7 years (range 5.5-43.1) were included: 100% were allergic to fruit; 72%, to peanut and/or nuts; 19 had a history of severe systemic reactions. Seven patients discontinued therapy; 3 (10%), due to adverse events. One year after SLIT start, 16 (73%) patients had negative OFC to peach; 95%, after 2 years; 69% had negative OFC to nuts/peanuts. The control group included 13 patients: 53.8% experienced reactions with new foods; severity of symptoms increased significantly (p < 0.001), and diet restrictions were maintained in this group. CONCLUSIONS: SLIT with Pru p 3 shows a good safety profile, and avoid dietary restrictions in patients with LTP syndrome treated in the real-life setting.


Subject(s)
Allergens/immunology , Antigens, Plant/immunology , Carrier Proteins/immunology , Food Hypersensitivity/immunology , Food Hypersensitivity/therapy , Plant Proteins/immunology , Adolescent , Adult , Child , Child, Preschool , Food Hypersensitivity/diagnosis , Humans , Severity of Illness Index , Sublingual Immunotherapy , Syndrome , Treatment Outcome , Young Adult
4.
Clin Exp Allergy ; 50(12): 1352-1361, 2020 12.
Article in English | MEDLINE | ID: mdl-32946612

ABSTRACT

BACKGROUND: In allergology, the intradermal approach is generally used to establish an aetiological diagnosis, with limited experience in specific allergen immunotherapy. OBJECTIVE: To evaluate the efficacy and safety of immunotherapy with an allergen extract of glutaraldehyde-polymerized Phleum pratense, administered intradermally, in patients with rhinoconjunctivitis sensitized to grass pollen. METHODS: Multicentre, randomized, double-blind, placebo-controlled clinical trial in patients from 12 to 65 years of age with rhinitis or rhinoconjunctivitis, with or without asthma, due to grass pollen allergy. Patients were divided into three groups and received a total of six doses in a weekly interval, of either placebo; 0.03 or 0.06 µg of protein per dose of P pratense allergoid. The primary objective was to evaluate the combined symptoms and medication consumption score (CSMS). The secondary objectives were symptoms and medication, tolerance to the conjunctival provocation test, specific IgE and IgG4 antibodies and the safety profile according to the WAO scale. RESULTS: The dose of 0.06 µg of protein proved to be effective versus the placebo by significantly reducing CSMS and increasing tolerance to the allergenic extract in the conjunctival provocation test, after the first pollen season. This group showed a significant reduction in specific IgE after the second pollen season relative to the baseline. There were no variations in IgG4 levels. Only one grade 2 systemic reaction was recorded. CONCLUSION & CLINICAL RELEVANCE: Intradermal immunotherapy with P pratense allergoid has been shown to be effective and safe, reducing CSMS, increasing tolerance to the conjunctival provocation test and reducing IgE levels.


Subject(s)
Allergens/administration & dosage , Conjunctivitis, Allergic/therapy , Desensitization, Immunologic , Phleum/immunology , Plant Proteins/administration & dosage , Pollen/immunology , Rhinitis, Allergic, Seasonal/therapy , Adolescent , Adult , Allergens/immunology , Biomarkers/blood , Conjunctivitis, Allergic/diagnosis , Conjunctivitis, Allergic/immunology , Double-Blind Method , Drug Administration Schedule , Female , Humans , Immune Tolerance/drug effects , Immunoglobulin E/blood , Immunoglobulin G/blood , Injections, Intradermal , Male , Middle Aged , Plant Proteins/immunology , Rhinitis, Allergic, Seasonal/diagnosis , Rhinitis, Allergic, Seasonal/immunology , Spain , Time Factors , Treatment Outcome , Young Adult
6.
A A Case Rep ; 8(9): 226-228, 2017 May 01.
Article in English | MEDLINE | ID: mdl-28181948

ABSTRACT

Mastocytosis comprises a heterogeneous group of disorders characterized by mast cell accumulation and proliferation in distinct organs. Kounis syndrome is defined as the concurrence of acute coronary syndromes with mast cell activation in a setting of allergic or hypersensitivity reactions. This is the first reported case of an intraoperative Kounis syndrome as the onset of an indolent systemic mastocytosis probably triggered by succinylated gelatin infusion during general anesthesia. The presentation of this case is intended to contribute to the knowledge of mastocytosis and Kounis syndrome at the time of diagnostic workup during intraoperative anaphylaxis or myocardial ischemia.


Subject(s)
Anesthesia, General/adverse effects , Gelatin/adverse effects , Kounis Syndrome/etiology , Mastocytosis, Systemic/chemically induced , Plasma Substitutes/adverse effects , Succinates/adverse effects , Gelatin/administration & dosage , Hemodynamics/drug effects , Humans , Infusions, Intravenous , Kounis Syndrome/diagnosis , Kounis Syndrome/physiopathology , Kounis Syndrome/therapy , Male , Mastocytosis, Systemic/diagnosis , Mastocytosis, Systemic/physiopathology , Mastocytosis, Systemic/therapy , Middle Aged , Orthopedic Procedures , Plasma Substitutes/administration & dosage , Risk Factors , Succinates/administration & dosage
SELECTION OF CITATIONS
SEARCH DETAIL
...