ABSTRACT
Invasive fungal infections most frequently caused by Aspergillus sp. and Candida sp. are significant causes of morbidity and mortality in severely immunocompromised patients, especially those who are neutropenic or who have undergone bone marrow or solid-organ transplant. We report a case of cutaneous hyalohyphomycosis in a 24-year-old female with acute lymphoblastic leukemia.
Subject(s)
Aspergillosis/complications , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Pregnancy Complications, Infectious , Pregnancy Complications, Neoplastic , Aspergillosis/pathology , Aspergillus , Fatal Outcome , Female , Humans , Pregnancy , Pregnancy Complications, Infectious/pathology , Young AdultABSTRACT
Las infecciones fúngicas causadas por Aspergillus sp. y Candida sp. son causa importante de morbilidad y mortalidad en pacientes gravemente inmunodeficientes, especialmente en aquellos con neutropenia o receptores de trasplante de médula ósea o de órganos sólidos. Informamos sobre una hialohifomicosis cutánea en una mujer de 24 años de edad con leucemia linfoblástica.
Invasive fungal infections most frequently caused by Aspergillus sp. and Candida sp. are significant causes of morbidity and mortality in severely immunocompromised patients, especially those who are neutropenic or who have undergone bone marrow or solid-organ transplant. We report a case of cutaneous hyalohyphomycosis in a 24-year-old female with acute lymphoblastic leukemia.
Subject(s)
Female , Humans , Pregnancy , Young Adult , Aspergillosis/complications , Pregnancy Complications, Infectious , Pregnancy Complications, Neoplastic , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Aspergillus , Aspergillosis/pathology , Fatal Outcome , Pregnancy Complications, Infectious/pathologyABSTRACT
Las infecciones fúngicas causadas por Aspergillus sp. y Candida sp. son causa importante de morbilidad y mortalidad en pacientes gravemente inmunodeficientes, especialmente en aquellos con neutropenia o receptores de trasplante de médula ósea o de órganos sólidos. Informamos sobre una hialohifomicosis cutánea en una mujer de 24 años de edad con leucemia linfoblástica.(AU)
Invasive fungal infections most frequently caused by Aspergillus sp. and Candida sp. are significant causes of morbidity and mortality in severely immunocompromised patients, especially those who are neutropenic or who have undergone bone marrow or solid-organ transplant. We report a case of cutaneous hyalohyphomycosis in a 24-year-old female with acute lymphoblastic leukemia.(AU)
Subject(s)
Female , Humans , Pregnancy , Young Adult , Aspergillosis/complications , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Pregnancy Complications, Infectious , Pregnancy Complications, Neoplastic , Aspergillosis/pathology , Aspergillus , Fatal Outcome , Pregnancy Complications, Infectious/pathologyABSTRACT
UNLABELLED: Graft versus host disease (GVHD) is a common complication in bone marrow transplant (BMT) patients. It is characterized by systemic and oral cavity alterations. Depending on the timing of lesions, GVHD is classified as acute or chronic. Alterations in the oral cavity are lichenoid reticular lesions, erythema, ulcerations, and xerostomia. Sporadically, mucocele and pyogenic granulomas can be present. AIM: To describe GVHD oral manifestations in eight allogenic BMT patients, and discuss GVHD and drug-immunosuppresion associated lesions diagnosis and treatment. STUDY DESIGN: For a year, we examined the oral mucosa of eight consecutive allogenic BMT patients attending the Dermatology out-patient clinic at the Instituto Nacional de Cancerologia (National Institute of Oncology) in Mexico City, looking for oral mucosa lesions. RESULTS: Patients were five men and three women, ages 24.8 -/+ 9.7 years. Four had a BMT because of chronic granulocytic, two for acute myeloblastic, one for acute lymphoblastic leukemia, and one for aplastic anemia. Three patients developed acute GVHD, with reticular oral mucosa lesions, erythema and mucositis; and all eight developed chronic GVHD, with reticular oral lesions, erythema, and ulcerations. A Patient had tongue and cheek pyogenic granulomas. Six reported xerostomia. Other oral lesions, associated to drug-immunosuppression, were candidiasis and herpes simplex. CONCLUSIONS: Patients with GVHD frequently develop oral lesions, some of which interfere with normal feeding; timely diagnosis and treatment are therefore essential to improve the quality of life of affected patients. We propose an alternative treatment for pyogenic granulomas.
Subject(s)
Graft vs Host Disease/complications , Mouth Diseases/etiology , Adolescent , Adult , Bone Marrow Transplantation/adverse effects , Female , Graft vs Host Disease/etiology , Humans , MaleABSTRACT
En un estudio longitudinal, comparativo al azar, se evaluó el efecto del benzoato de sodio (BS) sobre las pruebas de coagulación en un grupo de 10 sujetos con encefalopatía hepática severa, y se comparó con un grupo similar de 10 pacientes con encefalopatía hepática manejados con lactosa al 20 por ciento. En el grupo con BS, 8 sujetos fallecieron con agravamiento de la encefalopatía, 6 presentaron prolongación del tiempo parcial de tromboplastina (TTP) de 30" o más, no se registró modificación del tiempo de protrombina (TP). En el grupo que recibió lactosa hubo 3 defunciones (P=0.05), 1 sujeto presentó prolongación similar del TTP (P=0.025), 5 presentaron mejoría del mismo y tampoco hubo cambios del TP. Estos resultados sugieren que el BS prolonga el TTP y que la lactosa al 20 por ciento es una mejor opción que dicho fármaco en los pacientes con encefalopatía grave
