ABSTRACT
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic debilitating autoinflammatory skin disease. Adalimumab is the only biologic agent available to treat HS, but lack of response is observed in some patients. Ustekinumab may be useful to treat patients with HS who do not respond to adalimumab. OBJECTIVE: The objectives of this study were: (1) to retrospectively evaluate the therapeutic outcomes of ustekinumab in a multicenter series of patients with HS and (2) to assess all published scientific evidence on its utilization in patients with HS. METHODS: We evaluated the therapeutic outcomes of 10 patients with HS treated with ustekinumab and conducted a systematic review of published epidemiological studies on ustekinumab-treated patients with HS. RESULTS: In the case series, an improvement in the Physician Global Assessment score was observed in 70% (7/10) patients and an improvement in the Numerical Pain Rating Scale in 80% (8/10). In the systematic review, clinical improvement in disease severity was reported in 76% (34/45) patients and symptomatic improvement in 84% (38/45). No severe ustekinumab-related adverse event was recorded. CONCLUSION: These findings suggest that ustekinumab may be an effective and safe option for patients with HS who fail to respond to first-line therapies.
Subject(s)
Hidradenitis Suppurativa , Ustekinumab , Adalimumab/therapeutic use , Hidradenitis Suppurativa/drug therapy , Humans , Multicenter Studies as Topic , Retrospective Studies , Severity of Illness Index , Ustekinumab/therapeutic useABSTRACT
Idiopathic facial aseptic granuloma (IFAG) is a recently described and rare condition. It is considered a form of infantile granulomatous rosacea. IFAG with facial and eyelid nodules is very rare. A description is presented of three cases of IFAG eyelid nodules. They concern healthy children with no history of trauma. Biopsy examination revealed non-caseating inflammatory granulomas. Different medical treatments have been tried that seem to accelerate its healing, although its tendency is spontaneous resolution within several months. Painless recurrent eyelid nodules can be confused with chalazion. The diagnosis of IFAG should be considered in chronic eyelid nodules.
Subject(s)
Chalazion , Facial Dermatoses , Rosacea , Chalazion/diagnosis , Child , Eyelids , Facial Dermatoses/diagnosis , Granuloma/diagnosis , Humans , Rosacea/diagnosisSubject(s)
Anaphylaxis , Hymenoptera , Hypersensitivity , Insect Bites and Stings , Animals , Humans , Quality of LifeABSTRACT
El granuloma aséptico facial idiopático (GAFI) es una entidad recientemente descrita y poco frecuente. Se considera una forma de rosácea granulomatosa infantil. Es menos frecuente el GAFI con nódulos faciales y palpebrales asociados. Describimos 3casos GAFI que presentan esta asociación. Son niños sanos sin ningún antecedente traumático. El examen de la biopsia realizada en uno de los pacientes reveló granulomas inflamatorios no caseificantes. Se han ensayado distintos tratamientos médicos que parecen acelerar su curación, aunque su tendencia es la resolución espontánea en el plazo de varios meses. Los nódulos palpebrales indoloros de repetición se pueden confundir con el chalazión. Debemos pensar en GAFI ante nódulos palpebrales de larga evolución (AU)
Idiopathic facial aseptic granuloma (IFAG) is a recently described and rare condition. It is considered a form of infantile granulomatous rosacea. IFAG with facial and eyelid nodules is very rare. A description is presented of 3cases of IFAG eyelid nodules. They concern healthy children with no history of trauma. Biopsy examination revealed non-caseating inflammatory granulomas. Different medical treatments have been tried that seem to accelerate its healing, although its tendency is spontaneous resolution within several months. Painless recurrent eyelid nodules can be confused with chalazion. The diagnosis of IFAG should be considered in chronic eyelid nodules (AU)
Subject(s)
Infant , Child, Preschool , Child , Granuloma/diagnosis , Granuloma/therapy , Facial Dermatoses/diagnosis , Facial Dermatoses/therapy , Eyelid Diseases/diagnosis , Eyelid Diseases/therapyABSTRACT
Idiopathic facial aseptic granuloma (IFAG) is a recently described and rare condition. It is considered a form of infantile granulomatous rosacea. IFAG with facial and eyelid nodules is very rare. A description is presented of 3cases of IFAG eyelid nodules. They concern healthy children with no history of trauma. Biopsy examination revealed non-caseating inflammatory granulomas. Different medical treatments have been tried that seem to accelerate its healing, although its tendency is spontaneous resolution within several months. Painless recurrent eyelid nodules can be confused with chalazion. The diagnosis of IFAG should be considered in chronic eyelid nodules.
ABSTRACT
In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis.
Subject(s)
Arthropod Venoms/immunology , Hymenoptera/immunology , Hypersensitivity/immunology , Insect Bites and Stings/immunology , Animals , Arthropod Venoms/therapeutic use , Hypersensitivity/diagnosis , Hypersensitivity/epidemiology , Hypersensitivity/therapy , Immunologic Tests , Immunotherapy/methods , Insect Bites and Stings/diagnosis , Insect Bites and Stings/epidemiology , Insect Bites and Stings/therapy , Predictive Value of Tests , Risk Factors , Severity of Illness Index , Spain/epidemiology , Treatment OutcomeSubject(s)
Hypersensitivity/immunology , Larva , Moths , Animals , Child, Preschool , Female , Humans , Hypersensitivity/diagnosisABSTRACT
No disponible
No disponible
Subject(s)
Female , Child , Humans , Alopecia/etiology , Hair/abnormalitiesABSTRACT
Graham Little-Piccardi-Lassueur syndrome is characterized by the presence of cicatricial alopecia on the scalp, keratosis pilaris in the skin of trunk and extremities, and non-cicatricial hair loss in pubis and axillae. A frequent form of male pseudohermaphroditism is complete androgen insensitivity syndrome (CAIS), also known as testicular feminization syndrome. It refers to genetic males with XY karyotype who, owing to a lack of sensitivity in the peripheral androgenic receptors, develop a female phenotype. Axillary and pubic hair is typically scarce or absent. To our knowledge, this is the first case describing the association of the two processes. The presence of both processes in the same patient furthers our understanding of Graham Little-Piccardi-Lassueur syndrome as it rejects the influence of androgens in the alopecias accompanying this syndrome. The coincidence of non-cicatricial alopecia in axillary and pubic hair in both processes is also remarkable.
Subject(s)
Alopecia/complications , Androgen-Insensitivity Syndrome/complications , Cicatrix/complications , Keratosis/complications , Adult , Alopecia/pathology , Female , Humans , Keratosis/pathology , Male , Scalp Dermatoses/complications , SyndromeABSTRACT
The Laugier-Hunziker syndrome is an acquired, idiopathic, benign mucocutaneous hypermelanosis that usually occurs on the lips and oral mucosa, although it may appear at other sites. Nails are frequently involved, mainly forming longitudinal hyperpigmented bands. We report the case of a patient that presented a typical picture of this entity, nearly 1 year after the beginning of treatment with levodopa. Two years after the first lesions occurred, she developed Addison's disease. The patient suffered from a diffuse discrete hyperpigmentation (it was more remarkable on exposed areas) and an intensification of the melanotic macules that were previously noticeable before in oral and genital mucosa, fingers, toes and nails. Hormonal replacement treatment enabled the control of laboratory and general manifestations and to decrease the degree of mucocutaneous hyperpigmentation considerably, despite initial hyperpigmented lesions persisting in described areas.
Subject(s)
Addison Disease , Hyperpigmentation/diagnosis , Levodopa/therapeutic use , Aged , Diagnosis, Differential , Female , Fludrocortisone/therapeutic use , Foot Dermatoses/chemically induced , Foot Dermatoses/diagnosis , Foot Dermatoses/drug therapy , Foot Dermatoses/pathology , Hand Dermatoses/chemically induced , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Hand Dermatoses/pathology , Humans , Hydrocortisone/therapeutic use , Hyperpigmentation/chemically induced , Hyperpigmentation/drug therapy , Hyperpigmentation/pathology , Levodopa/administration & dosage , Mouth Mucosa , Parkinson Disease/drug therapy , Syndrome , VulvaABSTRACT
Varón de 79 años que presenta, en la areola mamaria izquierda, lesiones eccematosas. El estudio histopatológico de una biopsia revela hallazgos diagnósticos de enfermedad de Paget y carcinoma intraductral subyacente. Se realiza mastectomía radical modificada y terapia adyuvante con tamoxifeno y radioterapia. (AU)
Subject(s)
Aged , Male , Humans , Paget's Disease, Mammary/diagnosis , Paget's Disease, Mammary/surgery , Carcinoma/diagnosis , Carcinoma/surgery , Mastectomy, Modified Radical , Paget's Disease, Mammary/drug therapy , Paget's Disease, Mammary/radiotherapy , Carcinoma/drug therapy , Carcinoma/radiotherapy , Tamoxifen/therapeutic useABSTRACT
Un varón de 62 años, fumador de 20 cigarrillos al día, encontrándose previamente bien, presentó un cuadro de edema cervicofacial, ingurgitación yugular y signos de circulación colateral en el tórax. Ante la sospecha de un síndrome de la vena cava superior se realizó una radiografía de tórax que demostró la presencia de una masa mediastínica. Estudios posteriores demonstraron que dicha masa correspondía a un carcinoma microcítico de pulmón (AU)
